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Kalyango K.

Northern State Medical University

Dyachenko A.A.

Northern State Medical University

Bogdanov D.V.

Arkhangelsk Clinical Oncology Dispensary

Potekhina E.F.

Arkhangelsk Clinical Oncology Dispensary

Merabishvili V.M.

Petrov National Medical Research Center of Oncology

Valkov M.Yu.

Northern State Medical University;
Arkhangelsk Clinical Oncology Dispensary

Increment of the incidence of glioblastoma following decrease in the incidence of brain tumors in 2000-2020: a population-based registry study

Authors:

Kalyango K., Dyachenko A.A., Bogdanov D.V., Potekhina E.F., Merabishvili V.M., Valkov M.Yu.

More about the authors

Journal: Burdenko's Journal of Neurosurgery. 2022;86(5): 28‑36

DOI: 10.17116/neiro20228605128

Read: 5415 times

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Table of contents

INCREMENT OF THE INCIDENCE OF GLIOBLASTOMA FOLLOWING DECREASE IN THE INCIDENCE OF BRAIN TUMORS IN 2000-2020: A POPULATION-BASED REGISTRY STUDY
INCREMENT OF THE INCIDENCE OF GLIOBLASTOMA FOLLOWING DECREASE IN THE INCIDENCE OF BRAIN TUMORS IN 2000-2020: A POPULATION-BASED REGISTRY STUDY

To cite this article:

Kalyango K, Dyachenko AA, Bogdanov DV, Potekhina EF, Merabishvili VM, Valkov MYu. Increment of the incidence of glioblastoma following decrease in the incidence of brain tumors in 2000-2020: a population-based registry study. Burdenko's Journal of Neurosurgery. 2022;86(5):28‑36. (In Russ., In Engl.)
https://doi.org/10.17116/neiro20228605128

Подписка 2025 Журнал «Вопросы нейрохирургии» имени Н.Н. Бурденко (Burdenko's Journal of Neurosurgery)
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Использование инфографики авторами научных работ
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Abstract:

BACKGROUND

Prevalence and dynamics of certain morphological variants of neuroglial brain malignancies (ICD-10 C71) are unknown in the Russian Federation.

OBJECTIVE

To assess the incidence of neuroglial brain malignancies in 2000-2020 considering individual records of morphologically verified cases in the cancer registry of the Arkhangelsk region.

MATERIAL AND METHODS

We analyzed overall and age-adjusted incidence of neuroglial brain malignancies in 2000-2020 considering morphological subtypes of tumor. Incidence of morphologically verified glioblastoma was assessed in detail taking into account gender, age and place of residence. Segmented regression analysis was used to assess the dynamics and significance of linear trends.

RESULTS

In total, there were 1699 brain malignancies for the period from 2000 to 2020. Morphological verification was obtained in 1289 (76%) patients including 467 (27%), 92 (5%) and 307 (18%) ones with glioblastoma, anaplastic G3 glioma and G2 glioma, respectively. Percentage of glioblastoma and anaplastic gliomas increased from 23.4% and 3.9% in 2000 to 55.3% and 9.2% in 2020, respectively. Age-adjusted incidence for the entire C71 group decreased from 5.2 to 3.2 cases per 100,000 after 2015 (annual decline 7.1%). However, incidence of glioblastoma monotonously increased from 1.0 to 2.1 per 100,000 (annual increment 6.2%). Incidence was similar in men and women. Age-adjusted incidence was 50-70% higher among rural population.

CONCLUSION

Significant increase (>2 times) in the incidence of glioblastoma was found over the past twenty years. Probably, it is associated with improved diagnosis and registration of this disease. In-depth analysis of morbidity and survival of patients with rare neuroglial tumors is required.

Keywords:

cancer registry
brain malignancies
neuroglial tumors
glioblastoma
morbidity

Authors:

Kalyango K.

Northern State Medical University

Dyachenko A.A.

Northern State Medical University

Bogdanov D.V.

Arkhangelsk Clinical Oncology Dispensary

Potekhina E.F.

Arkhangelsk Clinical Oncology Dispensary

Merabishvili V.M.

Petrov National Medical Research Center of Oncology

Valkov M.Yu.

Northern State Medical University;
Arkhangelsk Clinical Oncology Dispensary

Received:

30.08.2021

Accepted:

19.08.2022

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