Periventricular changes following hydrocephalus: quantitative MR-based assessment of tissue characteristics

Turkin A.M.; Afandiev R.M.; Melnikova-Pitskhelauri T.V.; Fadeeva L.M.; Solozhentseva K.D.; Pogosbekyan E.L.; Oshorov A.V.; Pronin I.N.

doi:https://doi.org/10.17116/neiro20228604141

Turkin A.M.

Burdenko Neurosurgical Center

Afandiev R.M.

Burdenko Neurosurgical Center

ORCID: 0000-0001-6384-7960

Melnikova-Pitskhelauri T.V.

Burdenko Neurosurgical Center

Fadeeva L.M.

Burdenko Neurosurgical Center

Solozhentseva K.D.

Burdenko Center of Neurosurgery

Pogosbekyan E.L.

Burdenko Neurosurgical Center

Oshorov A.V.

Burdenko Neurosurgical Center

SPIN RSCI: 6630-6008
Scopus AuthorID: 24478016900
ORCID: 0000-0002-3674-252X

Pronin I.N.

Burdenko Neurosurgical Center

SPIN RSCI: 9223-9217
Scopus AuthorID: 7006011755
ORCID: 0000-0002-4480-0275

Periventricular changes following hydrocephalus: quantitative MR-based assessment of tissue characteristics

Authors:

Turkin A.M., Afandiev R.M., Melnikova-Pitskhelauri T.V., Fadeeva L.M., Solozhentseva K.D., Pogosbekyan E.L., Oshorov A.V., Pronin I.N.

More about the authors

Journal: Burdenko's Journal of Neurosurgery. 2022;86(4): 41‑49

DOI: 10.17116/neiro20228604141

Read: 8399 times

To cite this article:

Turkin AM, Afandiev RM, Melnikova-Pitskhelauri TV, et al. . Periventricular changes following hydrocephalus: quantitative MR-based assessment of tissue characteristics. Burdenko's Journal of Neurosurgery. 2022;86(4):41‑49. (In Russ., In Engl.)
https://doi.org/10.17116/neiro20228604141

Подписка 2025 Журнал «Вопросы нейрохирургии» имени Н.Н. Бурденко (Burdenko's Journal of Neurosurgery)

Использование инфографики авторами научных работ

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OBJECTIVE

To study tissue characteristics of periventricular white matter in patients with open hydrocephalus using DWI MRI and their correlations with CSF flow parameters.

MATERIAL AND METHODS

MRI was performed in 55 patients (35 women and 20 men) with open normal pressure hydrocephalus, as well as 16 patients with malignant occlusive hydrocephalus and interstitial edema (control group). We determined the correlations between severity of hydrocephalus, periventricular lesions and CSF flow parameters considering MR data. Dimensions of ventricular system were assessed using the Evans’ index, periventricular changes ― using visual four-level scale with calculation of apparent diffusion coefficient (ADC) and fractional anisotropy coefficient (FA).

RESULTS

Among patients with open hydrocephalus, ACD range for periventricular white matter was 1.57±0.15·10^-³ mm²/s in subgroup of patients without periventricular changes (n=29) and 1.62±0.11×10^-³ mm²/s in patients with periventricular changes (n=26). In the control group, mean ADC was 1.76±0.18·10^-³ mm²/s (p<0.05). In patients with open hydrocephalus, FA coefficient in the areas of periventricular changes was 0.70–0.80, in case of occlusive hydrocephalus ― 0.68–0.82. There was a significant relationship between the Evans’ index and CSF pulsation velocity amplitude, Evans’ index and stroke volume, Evans’ index and cerebral aqueduct cross-sectional area in patients with open hydrocephalus. Periventricular changes were pronounced in patients with open hydrocephalus and Evans’ index > 0.4 (p<0.05).

CONCLUSION

According to MR data, periventricular changes in patients with open hydrocephalus differ from true periventricular interstitial edema following occlusive hydrocephalus. Severity of periventricular changes in patients with open hydrocephalus depends on patient age and width of the ventricles, but does not correlate with CSF flow parameters. In our opinion, periventricular changes are associated with dysfunction of glymphatic system. Further research is required to study the functioning of glymphatic system and related processes.

Keywords:

hydrocephalus

periventricular changes

interstitial edema

glymphatic system

CSF flow

diffusion coefficient

fractional anisotropy

Authors:

Turkin A.M.

Burdenko Neurosurgical Center

Afandiev R.M.

Burdenko Neurosurgical Center

ORCID: 0000-0001-6384-7960

Melnikova-Pitskhelauri T.V.

Burdenko Neurosurgical Center

Fadeeva L.M.

Burdenko Neurosurgical Center

Solozhentseva K.D.

Burdenko Center of Neurosurgery

Pogosbekyan E.L.

Burdenko Neurosurgical Center

Oshorov A.V.

Burdenko Neurosurgical Center

SPIN RSCI: 6630-6008
Scopus AuthorID: 24478016900
ORCID: 0000-0002-3674-252X

Pronin I.N.

Burdenko Neurosurgical Center

SPIN RSCI: 9223-9217
Scopus AuthorID: 7006011755
ORCID: 0000-0002-4480-0275

Received:

17.06.2021

Accepted:

10.06.2022

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