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Bogoslovskaya E.A.

Russian Medical Academy of Continuous Professional Education;
«Surgut Clinical Trauma Hospital»

Gorelyshev S.K.

Russian Medical Academy of Continuous Professional Education;
National Medical Research Center for Neurosurgery named after Academician N.N. Burdenko

Tomale U.V.

Charité Universitätsklinikum Berlin Campus Virchow Klinikum

Akimov A.Yu.

Children’s Republican Clinical Hospital

Alekseev A.V.

Chelyabinsk Regional Children’s Clinical Hospital

Bardeeva K.A.

Omsk Regional Children’s Clinical Hospital

Demyanenko V.V.

Regional Children’s Clinical Hospital of the Krasnodar Territory

Zolotarev S.S.

Regional Children’s Clinical Hospital of the Krasnodar Territory

Kirsanov S.A.

Penza Regional Children’s Clinical Hospital named after N.F. Filatov

Kovalkov K.A.

Kuzbass Regional Children’s Clinical Hospital named after Yu.A. Atamanov

Larkin I.I.

City Clinical Perinatal Center

Medoev S.B.

Children’s City Clinical Hospital named after Z.A. Bashlyaeva

Pankratiev R.M.

Republicam Children’s Clinical Hospital

Pogosova D.R.

Chelyabinsk Regional Children’s Clinical Hospital

Seliverstov A.V.

Kuzbass Regional Children’s Clinical Hospital named after Yu.A. Atamanov

Sukharev A.S.

Regional Children’s Clinical Hospital of the Sverdlovsk Region

Timershin A.G.

Republicam Children’s Clinical Hospital

Usatova O.A.

Chelyabinsk Regional Children’s Clinical Hospital

Fatykhova E.F.

Children’s Republican Clinical Hospital

Shapovalov A.S.

Almazov National Medical Research Center

Surgical treatment of posthemorrhagic hydrocephalus in premature infants

Authors:

Bogoslovskaya E.A., Gorelyshev S.K., Tomale U.V., Akimov A.Yu., Alekseev A.V., Bardeeva K.A., Demyanenko V.V., Zolotarev S.S., Kirsanov S.A., Kovalkov K.A., Larkin I.I., Medoev S.B., Pankratiev R.M., Pogosova D.R., Seliverstov A.V., Sukharev A.S., Timershin A.G., Usatova O.A., Fatykhova E.F., Shapovalov A.S.

More about the authors

Journal: Burdenko's Journal of Neurosurgery. 2025;89(4): 7‑17

DOI: 10.17116/neiro2025890417

Read: 882 times

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Table of contents

SURGICAL TREATMENT OF POSTHEMORRHAGIC HYDROCEPHALUS IN PREMATURE INFANTS
SURGICAL TREATMENT OF POSTHEMORRHAGIC HYDROCEPHALUS IN PREMATURE INFANTS

To cite this article:

Bogoslovskaya EA, Gorelyshev SK, Tomale UV, et al. . Surgical treatment of posthemorrhagic hydrocephalus in premature infants. Burdenko's Journal of Neurosurgery. 2025;89(4):7‑17. (In Russ., In Engl.)
https://doi.org/10.17116/neiro2025890417

Подписка 2025 Журнал «Вопросы нейрохирургии» имени Н.Н. Бурденко (Burdenko's Journal of Neurosurgery)
 
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Использование инфографики авторами научных работ
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Abstract:

RATIONALE

Hydrocephalus as a consequence of intraventricular hemorrhage (IVH) in premature infants is a life-threatening complication of the neonatal period. The question remains as to which methods are best to be used for temporary drainage of cerebrospinal fluid until sufficient body mass for possible shunt implantation is achieved.

OBJECTIVE

Is to compare four methods of temporary treatment of posthemorrhagic hydrocephalus in terms of their safety and effectiveness.

MATERIAL AND METHODS

A multicenter (12 healthcare facilities of the Russian Federation) prospective study included 165 premature infants with IVH and signs of worsening enlargement of the ventricles. External ventricular drainage (EVD) was used in 43 observations, ventriculosubgaleal shunt (VSGS) in 93 observations, neuroendoscopic lavage (NEL) in 25 observations and Ommaya reservoir — in 4. Methods were compared by effectiveness and postoperative complications. The examination of patients in catamnesis was carried out at the age of 6, 12, 24 and 36 months.

RESULTS

Differences regarding brain tissue defect in the access zone (the highest in the NEL group and the lowest in EVD group, p<0.001); multilocular hydrocephalus frequency (the highest in the EVD group — 33% and the lowest in the NEL group — 17%, p<0.05); proportion of patients in need of permanent shunting (the highest indicator in the VSGS group — 88.1% and the lowest in the NEL group — 57%, p<0.001); number of infectious complications (most of all in the EVD group — 12%, the lowest in the NEL group — 0%) have been revealed. The best indicators of children’s motor development have been noted in the NEL group (2.25), the worst in the EVD group — 3.75. Long-term mortality in the distant period amounted to 7%.

CONCLUSION

The most effective method of temporary arresting of hydrocephalus is neuroendoscopic lavage. It has a minimal number of infectious and other complications, the best hydrocephalus stabilization, low percentage of complicated hydrocephalus (multilocular) and the best motor development indicators and does not require reinterventions.

Keywords:

newborns
premature infants
intraventricular hemorrhage
hydrocephalus
neuroendoscopic lavage
external drainage of the ventricles
ventriculosubgaleal shunt
Ommaya reservoir

Authors:

Bogoslovskaya E.A.

Russian Medical Academy of Continuous Professional Education;
«Surgut Clinical Trauma Hospital»

Gorelyshev S.K.

Russian Medical Academy of Continuous Professional Education;
National Medical Research Center for Neurosurgery named after Academician N.N. Burdenko

Tomale U.V.

Charité Universitätsklinikum Berlin Campus Virchow Klinikum

Akimov A.Yu.

Children’s Republican Clinical Hospital

Alekseev A.V.

Chelyabinsk Regional Children’s Clinical Hospital

Bardeeva K.A.

Omsk Regional Children’s Clinical Hospital

Demyanenko V.V.

Regional Children’s Clinical Hospital of the Krasnodar Territory

Zolotarev S.S.

Regional Children’s Clinical Hospital of the Krasnodar Territory

Kirsanov S.A.

Penza Regional Children’s Clinical Hospital named after N.F. Filatov

Kovalkov K.A.

Kuzbass Regional Children’s Clinical Hospital named after Yu.A. Atamanov

Larkin I.I.

City Clinical Perinatal Center

Medoev S.B.

Children’s City Clinical Hospital named after Z.A. Bashlyaeva

Pankratiev R.M.

Republicam Children’s Clinical Hospital

Pogosova D.R.

Chelyabinsk Regional Children’s Clinical Hospital

Seliverstov A.V.

Kuzbass Regional Children’s Clinical Hospital named after Yu.A. Atamanov

Sukharev A.S.

Regional Children’s Clinical Hospital of the Sverdlovsk Region

Timershin A.G.

Republicam Children’s Clinical Hospital

Usatova O.A.

Chelyabinsk Regional Children’s Clinical Hospital

Fatykhova E.F.

Children’s Republican Clinical Hospital

Shapovalov A.S.

Almazov National Medical Research Center

Received:

29.04.2025

Accepted:

05.06.2025

Close metadata

References:

  1. Thomale UW. Integrated understanding of hydrocephalus — a practical approach for a complex disease. Child’s Nervous System. 2021;37(11):3313-3324. https://doi.org/10.1007/s00381-021-05243-3
  2. Garvey AA, Walsh BH, Inder TE. Pathogenesis and prevention of intraventricular hemorrhage. Seminars in Perinatology. 2022;46(5):151592. https://doi.org/10.1016/j.semperi.2022.151592
  3. Ballabh P, de Vries LS. White matter injury in infants with intraventricular haemorrhage: mechanisms and therapies. Nature Reviews Neurology. 2021;17(4):199-214.  https://doi.org/10.1038/s41582-020-00447-8
  4. Holste KG, Xia F, Ye F, Keep RF, Xi G. Mechanisms of neuroinflammation in hydrocephalus after intraventricular hemorrhage: a review. Fluids and Barriers of the CNS. 2022;19(1):28.  https://doi.org/10.1186/s12987-022-00324-0
  5. Gorelyshev SK, Zaplatnikov AL, Bogoslovskaya EA, Dement’ev AA, Chabaidze ZhL, Pogosova DR, Smirnov DN. Antenatal and intrapartum risk factors and modern possibilities for the prevention of intraventricular hemorrhages in premature infants: a systematic review. Russian Journal of Woman and Child Health. 2025;8(1):63-71. (In Russ.).. https://doi.org/10.32364/2618-8430-2025-8-1-10
  6. Bębenek AK, Kwiatkowski S, Milczarek O. Potential Risk Factors for Ventriculoperitoneal Shunt Implantation in Paediatric Patients with Posthemorrhagic Hydrocephalus of Prematurity Treated with Subcutaneous Reservoir: An Institutional Experience. Neuropediatrics. 2022;53(1):1-6.  https://doi.org/10.1055/s-0041-1732311
  7. De Angelis LC, Parodi A, Sebastiani M, Consales A, Ravegnani GM, Severino M, Tortora D, Rossi A, Malova M, Minghetti D, Cama A, Piatelli G, Ramenghi LA. External ventricular drainage for posthemorrhagic ventricular dilatation in preterm infants: insights on efficacy and failure. Journal of Neurosurgery: Pediatrics. 2021;28(5):563-571.  https://doi.org/10.3171/2021.5.PEDS20928
  8. Fountain DM, Chari A, Allen D, James G. Comparison of the use of ventricular access devices and ventriculosubgaleal shunts in posthaemorrhagic hydrocephalus: systematic review and meta-analysis. Child’s Nervous System. 2016;32(2):259-267.  https://doi.org/10.1007/s00381-015-2951-8
  9. Mazzola CA, Choudhri AF, Auguste KI, Limbrick DD Jr, Rogido M, Mitchell L, Flannery AM; Pediatric Hydrocephalus Systematic Review and Evidence-Based Guidelines Task Force. Pediatric hydrocephalus: systematic literature review and evidence-based guidelines. Part 2: Management of posthemorrhagic hydrocephalus in premature infants. Journal of Neurosurgery: Pediatrics. 2014;14(1):8-23.  https://doi.org/10.3171/2014.7.PEDS14322
  10. Thomale UW, Auer C, Spennato P, Schaumann A, Behrens P, Gorelyshev S, Bogoslovskaia E, Shulaev A, Kabanian A, Seliverstov A, Alexeev A, Ozgural O, Kahilogullari G, Schuhmann M, Jimenez-Guerra R, Wittayanakorn N, Sukharev A, Marquez-Rivas J, Linsler S, Damaty AE, Vacek P, Lovha M, Guzman R, Stricker S, Beez T, Wiegand C, Azab M, Buis D, Sáez M, Fleck S, Dziugan C, Ferreira A, Radovnicky T, Bührer C, Lam S, Sgouros S, Roth J, Constantini S, Cavalheiro S, Cinalli G, Kulkarni AV, Bock HC. TROPHY registry — status report. Child’s Nervous System. 2021;37(11):3549-3554. https://doi.org/10.1007/s00381-021-05258-w
  11. Wassef CE, Thomale UW, LoPresti MA, DeCuypere MG, Raskin JS, Mukherjee S, Aquilina K, Lam SK. Experience in endoscope choice for neuroendoscopic lavage for intraventricular hemorrhage of prematurity: a systematic review. Child’s Nervous System. 2024;40(8):2373-2384. https://doi.org/10.1007/s00381-024-06408-6
  12. Frassanito P, Serrao F, Gallini F, Bianchi F, Massimi L, Vento G, Tamburrini G. Ventriculosubgaleal shunt and neuroendoscopic lavage: refining the treatment algorithm of neonatal post-hemorrhagic hydrocephalus. Child’s Nervous System. 2021;37(11):3531-3540. https://doi.org/10.1007/s00381-021-05216-6
  13. Papile LA, Burstein J, Burstein R, Koffler H. Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm. The Journal of Pediatrics. 1978;92(4):529-534.  https://doi.org/10.1016/s0022-3476(78)80282-0
  14. Volpe JJ. Intracranial hemorrhage: Germinal matrix-intraventricular hemorrhage of the premature infant. In: Volpe JJ, ed. Neurology of the Newborn. Philadephia PA, USA: Saunders; 2001.
  15. Bauer DF, Baird LC, Klimo P, Mazzola CA, Nikas DC, Tamber MS, Flannery AM. Congress of Neurological Surgeons Systematic Review and Evidence-Based Guidelines on the Treatment of Pediatric Hydrocephalus: Update of the 2014 Guidelines. Neurosurgery. 2020;87(6):1071-1075. https://doi.org/10.1093/neuros/nyaa434
  16. de Vries LS, Liem KD, van Dijk K, Smit BJ, Sie L, Rademaker KJ, Gavilanes AW; Dutch Working Group of Neonatal Neurology. Early versus late treatment of posthaemorrhagic ventricular dilatation: results of a retrospective study from five neonatal intensive care units in The Netherlands. Acta Paediatrica. 2002;91(2):212-217.  https://doi.org/10.1080/080352502317285234
  17. Cizmeci MN, de Vries LS, Tataranno ML, Zecic A, van de Pol LA, Alarcon A, Groenendaal F, Woerdeman PA. Intraparenchymal hemorrhage after serial ventricular reservoir taps in neonates with hydrocephalus and association with neurodevelopmental outcome at 2 years of age. Journal of Neurosurgery: Pediatrics. 2021;28(6):695-702.  https://doi.org/10.3171/2021.6.PEDS21120
  18. Isaacs AM, Shannon CN, Browd SR, Hauptman JS, Holubkov R, Jensen H, Kulkarni AV, McDonald PJ, McDowell MM, Naftel RP, Nunn N, Pindrik J, Pollack IF, Reeder R, Riva-Cambrin J, Rozzelle CJ, Rocque BG, Strahle JM, Tamber MS, Whitehead WE, Kestle JRW, Limbrick DD, Wellons JC. Neurodevelopmental outcomes of permanent and temporary CSF diversion in posthemorrhagic hydrocephalus: a Hydrocephalus Clinical Research Network study. Journal of Neurosurgery: Pediatrics. 2025;35(4):315-326.  https://doi.org/10.3171/2024.10.PEDS24257
  19. Tirado-Caballero J, Herreria-Franco J, Rivero-Garvía M, Moreno-Madueño G, Mayorga-Buiza MJ, Marquez-Rivas J. Technical Nuances in Neuroendoscopic Lavage for Germinal Matrix Hemorrhage in Preterm Infants: Twenty Tips and Pearls after More than One Hundred Procedures. Pediatric Neurosurgery. 2021;56(4):392-400.  https://doi.org/10.1159/000516183
  20. Dvalishvili A, Khinikadze M, Gegia G, Khutsishvili L. Neuroendoscopic lavage versus traditional surgical methods for the early management of posthemorrhagic hydrocephalus in neonates. Child’s Nervous System. 2022;38(10):1897-1902. https://doi.org/10.1007/s00381-022-05606-4
  21. Islas-Aguilar MA, Torrez-Corzo JGA, Chalita-Williams JC, Cervantes DS, Vinas-Rios J. Neuroendoscopic Lavage and Third Ventriculostomy for the Treatment of Intraventricular Hemorrhage and Hydrocephalus in Neonates. A Prospective Study with 18 Months of Follow-Up. Journal of Neurological Surgery Part A: Central European Neurosurgery. 2024;85(3):274-279.  https://doi.org/10.1055/s-0043-1770358
  22. Tirado-Caballero J, Rivero-Garvia M, Arteaga-Romero F, Herreria-Franco J, Lozano-Gonzalez Á, Marquez-Rivas J. Neuroendoscopic lavage for the management of posthemorrhagic hydrocephalus in preterm infants: safety, effectivity, and lessons learned. Journal of Neurosurgery: Pediatrics. 2020;26(3):237-246.  https://doi.org/10.3171/2020.2.PEDS2037
  23. Kandula V, Mohammad LM, Thirunavu V, LoPresti M, Beestrum M, Lai GY, Lam SK. The role of blood product removal in intraventricular hemorrhage of prematurity: a meta-analysis of the clinical evidence. Child’s Nervous System. 2022;38(2):239-252.  https://doi.org/10.1007/s00381-021-05400-8
  24. Behrens P, Tietze A, Walch E, Bittigau P, Bührer C, Schulz M, Aigner A, Thomale UW. Neurodevelopmental outcome at 2 years after neuroendoscopic lavage in neonates with posthemorrhagic hydrocephalus. Journal of Neurosurgery: Pediatrics. 2020;26(5):495-503.  https://doi.org/10.3171/2020.5.PEDS20211
  25. Whitelaw A, Jary S, Kmita G, Wroblewska J, Musialik-Swietlinska E, Mandera M, Hunt L, Carter M, Pople I. Randomized trial of drainage, irrigation and fibrinolytic therapy for premature infants with posthemorrhagic ventricular dilatation: developmental outcome at 2 years. Pediatrics. 2010;125(4):e852-858.  https://doi.org/10.1542/peds.2009-1960
  26. Park YS. Perspectives: Understanding the Pathophysiology of Intraventricular Hemorrhage in Preterm Infants and Considering of the Future Direction for Treatment. Journal of Korean Neurosurgical Society. 2023;66(3):298-307.  https://doi.org/10.3340/jkns.2023.0020
  27. Wang JY, Amin AG, Jallo GI, Ahn ES. Ventricular reservoir versus ventriculosubgaleal shunt for posthemorrhagic hydrocephalus in preterm infants: infection risks and ventriculoperitoneal shunt rate. Journal of Neurosurgery: Pediatrics. 2014;14(5):447-454.  https://doi.org/10.3171/2014.7.PEDS13552
  28. Hall BJ, Duddy JC, Apostolopoulou K, Pettorini B. A tailored approach to the management of post-haemorrhagic hydrocephalus. Child’s Nervous System. 2024;40(3):665-671.  https://doi.org/10.1007/s00381-023-06214-6
  29. Etus V, Kahilogullari G, Karabagli H, Unlu A. Early Endoscopic Ventricular Irrigation for the Treatment of Neonatal Posthemorrhagic Hydrocephalus: A Feasible Treatment Option or Not? A Multicenter Study. Turkish Neurosurgery. 2018;28(1):137-141.  https://doi.org/10.5137/1019-5149.JTN.18677-16.0
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