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Vikhrova N.B.

Burdenko Neurosurgical Center

Kalaeva D.B.

Burdenko Center of Neurosurgery;
National Research Nuclear University MEPhI (Moscow Engineering Physics Institute)

Postnov A.A.

Burdenko National Medical Scientific Center for Neurosurgery;
National Research Nuclear University MEPhI (Moscow Engineering Physics Institute);
Lebedev Physical Institute of the Russian Academy of Sciences

Khokhlova E.V.

Burdenko National Medical Scientific Center for Neurosurgery

Konakova T.A.

Burdenko National Medical Scientific Center for Neurosurgery

Batalov A.I.

Burdenko Neurosurgical Center

Pogosbekyan E.L.

Burdenko Neurosurgical Center

Pronin I.N.

Burdenko Neurosurgical Center

Dynamic11C-methionine PET/CT in differential diagnosis of brain gliomas

Authors:

Vikhrova N.B., Kalaeva D.B., Postnov A.A., Khokhlova E.V., Konakova T.A., Batalov A.I., Pogosbekyan E.L., Pronin I.N.

More about the authors

Journal: Burdenko's Journal of Neurosurgery. 2021;85(3): 5‑13

DOI: 10.17116/neiro2021850315

Read: 5101 times

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Table of contents

DYNAMIC11C-METHIONINE PET/CT IN DIFFERENTIAL DIAGNOSIS OF BRAIN GLIOMAS
DYNAMIC11C-METHIONINE PET/CT IN DIFFERENTIAL DIAGNOSIS OF BRAIN GLIOMAS

To cite this article:

Vikhrova NB, Kalaeva DB, Postnov AA, et al. . Dynamic11C-methionine PET/CT in differential diagnosis of brain gliomas. Burdenko's Journal of Neurosurgery. 2021;85(3):5‑13. (In Russ., In Engl.)
https://doi.org/10.17116/neiro2021850315

Подписка 2025 Журнал «Вопросы нейрохирургии» имени Н.Н. Бурденко (Burdenko's Journal of Neurosurgery)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE

To evaluate the possibilities of dynamic preoperative 11C-methionine (MET) PET/CT in differential diagnosis of various types of brain gliomas in adults.

MATERIAL AND METHODS

The study included 74 patients aged 48±14 years with supratentorial gliomas: Grade IV — glioblastoma (GB, n=33), Grade III — anaplastic oligodendroglioma (AOD, n=10) and anaplastic astrocytoma (AA, n=12), Grade II — diffuse astrocytoma (DA, n=13) and oligodendroglioma (OD, n=6). All patients underwent standard MRI and dynamic MET PET/CT within 20 minutes after intravenous injection of radiopharmaceutical. Then, we compared MRI and PET/CT data and comprehensively analyzed the early stages of time-activity curve using 2 parameters: the first pass peak (FPP) and the first peak of maximum uptake (Pmax).

RESULTS

We have significantly distinguished high-grade tumors (GB and AA+AOD) and certain benign gliomas (DA and OD) (p<0.05). AUC was over 0.7 and 0.8 for FPP and Pmax in differential diagnosis of various gliomas, respectively. We found that difficulties in differential diagnosis of gliomas arise mainly if oligodendrogliomas are included in the control group.

CONCLUSION

Dynamic PET/CT with analysis of FPP and Pmax increases specificity of differential diagnosis of various gliomas compared to standard static imaging. These data are valuable for choice of optimal treatment strategy, as well as fundamental research of metabolic processes and vascularization of various tumors.

Keywords:

PET/CT
dynamic PET
11C-methionine
MET
glioma
brain tumor
glioblastoma
anaplastic astrocytoma
oligodendroglioma

Authors:

Vikhrova N.B.

Burdenko Neurosurgical Center

Kalaeva D.B.

Burdenko Center of Neurosurgery;
National Research Nuclear University MEPhI (Moscow Engineering Physics Institute)

Postnov A.A.

Burdenko National Medical Scientific Center for Neurosurgery;
National Research Nuclear University MEPhI (Moscow Engineering Physics Institute);
Lebedev Physical Institute of the Russian Academy of Sciences

Khokhlova E.V.

Burdenko National Medical Scientific Center for Neurosurgery

Konakova T.A.

Burdenko National Medical Scientific Center for Neurosurgery

Batalov A.I.

Burdenko Neurosurgical Center

Pogosbekyan E.L.

Burdenko Neurosurgical Center

Pronin I.N.

Burdenko Neurosurgical Center

Received:

08.06.2020

Accepted:

19.03.2021

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