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Batalov A.I.

Burdenko Neurosurgical Institute, Moscow, Russia

Zakharova N.E.

NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva

Pogosbekyan E.L.

Burdenko Neurosurgical Institute, Moscow, Russia

Fadeeva L.M.

NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva

Goriaĭnov S.A.

NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva

Baev A.A.

Burdenko Neurosurgical Institute, Moscow, Russia

Shul'ts E.I.

FGBU "NII neĭrokhirurgii im. akad. N.N. Burdenko" RAMN, Moskva

Chelushkin D.M.

Burdenko Neurosurgical Institute, 4-ya Tverskaya-Yamskaya Str., 16, Moscow, Russia, 125047

Potapov A.A.

NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva

Pronin I.N.

NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva

Non-contrast ASL perfusion in preoperative diagnosis of supratentorial gliomas

Authors:

Batalov A.I., Zakharova N.E., Pogosbekyan E.L., Fadeeva L.M., Goriaĭnov S.A., Baev A.A., Shul'ts E.I., Chelushkin D.M., Potapov A.A., Pronin I.N.

More about the authors

Journal: Burdenko's Journal of Neurosurgery. 2018;82(6): 15‑22

DOI: 10.17116/neiro20188206115

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Table of contents

NON-CONTRAST ASL PERFUSION IN PREOPERATIVE DIAGNOSIS OF SUPRATENTORIAL GLIOMAS
NON-CONTRAST ASL PERFUSION IN PREOPERATIVE DIAGNOSIS OF SUPRATENTORIAL GLIOMAS

To cite this article:

Batalov AI, Zakharova NE, Pogosbekyan EL, et al. . Non-contrast ASL perfusion in preoperative diagnosis of supratentorial gliomas. Burdenko's Journal of Neurosurgery. 2018;82(6):15‑22. (In Russ., In Engl.)
https://doi.org/10.17116/neiro20188206115

Подписка 2025 Журнал «Вопросы нейрохирургии» имени Н.Н. Бурденко (Burdenko's Journal of Neurosurgery)
 
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Abstract:

The purpose of this study was to investigate the potential of pseudocontinuous arterial spin labeling perfusion (pCASL) in assessing the degree of malignancy of brain gliomas at the preoperative stage. Material and methods. The study included 126 patients aged 12―75 years with supratentorial gliomas of different malignancy (35 low-grade gliomas and 91 high-grade gliomas). The maximum tumor blood flow (TBF) was measured, and the normalized tumor blood flow (nTBF) was calculated relative to the intact semiovale white matter of the contralateral hemisphere. The TBF and nTBF indicators differed significantly between low-grade and high-grade glioma groups (p<0.001). When using TBF and nTBF in the differential diagnosis of low-grade and high-grade gliomas, the area under the ROC curve was 0.96 in both cases. Our findings suggest that 3D pCASL perfusion is an effective technique for preoperative differential diagnosis of low-grade and high-grade gliomas. The study was supported by the Russian Foundation for Basic Research (grant №18-315-00384).

Keywords:

magnetic resonance imaging
pseudocontinuous arterial spin labeling
pCASL
cerebral blood flow
CBF
tumor blood flow
TBF
gliomas

Authors:

Batalov A.I.

Burdenko Neurosurgical Institute, Moscow, Russia

Zakharova N.E.

NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva

Pogosbekyan E.L.

Burdenko Neurosurgical Institute, Moscow, Russia

Fadeeva L.M.

NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva

Goriaĭnov S.A.

NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva

Baev A.A.

Burdenko Neurosurgical Institute, Moscow, Russia

Shul'ts E.I.

FGBU "NII neĭrokhirurgii im. akad. N.N. Burdenko" RAMN, Moskva

Chelushkin D.M.

Burdenko Neurosurgical Institute, 4-ya Tverskaya-Yamskaya Str., 16, Moscow, Russia, 125047

Potapov A.A.

NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva

Pronin I.N.

NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva

Close metadata

References:

  1. Louis D, Perry A, Reifenberger G, von Deimling A, Figarella-Branger D, Cavenee W, Ohgaki H, Wiestler O, Kleihues P, Ellison D. The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary. Acta Neuropathol. 2016;131(6):803-820. https://doi.org/10.1007/s00401-016-1545-1
  2. Schwartzbaum J, Fisher J, Aldape K, Wrensch M. Epidemiology and molecular pathology of glioma. Nature Clinical Practice Neurology. 2006;2(9):494-503. https://doi.org/10.1038/ncpneuro0289
  3. Soffietti R, Baumert B, Bello L, Von Deimling A, Duffau H, Frénay M, Grisold W, Grant R, Graus F, Hoang-Xuan K, Klein M, Melin B, Rees J, Siegal T, Smits A, Stupp R, Wick W. Guidelines on management of low-grade gliomas: report of an EFNS-EANO* Task Force. Eur J Neurol. 2010;17(9):1124-1133. https://doi.org/10.1111/j.1468-1331.2010.03151.x
  4. Weller M, van den Bent M, Hopkins K, Tonn J, Stupp R, Falini A, Cohen-Jonathan-Moyal E, Frappaz D, Henriksson R, Balana C, Chinot O, Ram Z, Reifenberger G, Soffietti R, Wick W. EANO guideline for the diagnosis and treatment of anaplastic gliomas and glioblastoma. The Lancet Oncology. 2014;15(9):e395-e403. https://doi.org/10.1016/s1470-2045(14)70011-7
  5. Nguyen T, Cron G, Perdrizet K, Bezzina K, Torres C, Chakraborty S, Woulfe J, Jansen G, Sinclair J, Thornhill R, Foottit C, Zanette B, Cameron I. Comparison of the Diagnostic Accuracy of DSC- and Dynamic Contrast-Enhanced MRI in the Preoperative Grading of Astrocytomas. American Journal of Neuroradiology. 2015;36(11):2017-2022. https://doi.org/10.3174/ajnr.a4398
  6. Roy B, Awasthi R, Bindal A, Sahoo P, Kumar R, Behari S, Ojha B, Husain N, Pandey C, Rathore R, Gupta R. Comparative Evaluation of 3-Dimensional Pseudocontinuous Arterial Spin Labeling With Dynamic Contrast-Enhanced Perfusion Magnetic Resonance Imaging in Grading of Human Glioma. J Comput Assist Tomogr. 2013;37(3):321-326. https://doi.org/10.1097/rct.0b013e318282d7e2
  7. Knopp E, Cha S, Johnson G, Mazumdar A, Golfinos JG, Zagzag D, Miller DC, Kelly PJ, Kricheff II. Glial Neoplasms: Dynamic Contrast-enhanced T2*-weighted MR Imaging. Radiology. 1999;211(3):791-798. https://doi.org/10.1148/radiology.211.3.r99jn46791
  8. Law M, Yang S, Babb JS, Knopp E, Golfinos J, Zagzag D, Johnson G. Comparison of cerebral blood volume and vascular permeability from dynamic susceptibility contrast enhanced perfusion MR imaging with glioma grade. American Journal of Neuroradiology. 2004;25(5):746-755.
  9. Law M, Young R, Babb J, Peccerelli N, Chheang S, Gruber ML, Miller DC, Golfinos JG, Zagzag D, Johnson G et al. Gliomas: Predicting Time to Progression or Survival with Cerebral Blood Volume Measurements at Dynamic Susceptibility-weighted Contrast-enhanced Perfusion MR Imaging. Radiology. 2008;247(2):490-498. https://doi.org/10.1148/radiol.2472070898
  10. Furtner J, Schöpf V, Schewzow K, Kasprian G, Weber M, Woitek R, Asenbaum U, Preusser M, Marosi C, Hainfellner J, Widhalm G, Wolfsberger S, Prayer D. Arterial Spin-Labeling Assessment of Normalized Vascular Intratumoral Signal Intensity as a Predictor of Histologic Grade of Astrocytic Neoplasms. American Journal of Neuroradiology. 2013;35(3):482-489. https://doi.org/10.3174/ajnr.a3705
  11. Rau M, Braun C, Skardelly M, Schittenhelm J, Paulsen F, Bender B, Ernemann U, Bisdas S. Prognostic value of blood flow estimated by arterial spin labeling and dynamic susceptibility contrast-enhanced MR imaging in high-grade gliomas. J Neurooncol. 2014;120(3):557-566. https://doi.org/10.1007/s11060-014-1586-z
  12. Chawla S, Wang S, Wolf R, Woo JH, Wang J, O`Rourke DM, Judy KD, Grady MS, Melhem ER, Poptani H. Arterial Spin-Labeling and MR Spectroscopy in the Differentiation of Gliomas. American Journal of Neuroradiology. 2007;28(9):1683-1689. https://doi.org/10.3174/ajnr.a0673
  13. Fudaba H, Shimomura T, Abe T, Matsuta H, Momii Y, Sugita K, Ooba H, Kamida T, Hikawa T, Fujiki M. Comparison of Multiple Parameters Obtained on 3T Pulsed Arterial Spin-Labeling, Diffusion Tensor Imaging, and MRS and the Ki-67 Labeling Index in Evaluating Glioma Grading. American Journal of Neuroradiology. 2014;35(11):2091-2098. https://doi.org/10.3174/ajnr.a4018
  14. Furtner J, Bender B, Braun C, Schittenhelm J, Skardelly M, Ernemann U, Bisdas S. Prognostic Value of Blood Flow Measurements Using Arterial Spin Labeling in Gliomas. PLoS ONE. 2014;9(6):e99616. https://doi.org/10.1371/journal.pone.0099616
  15. Kim H, Kim S. A prospective study on the added value of pulsed arterial spin-labeling and apparent diffusion coefficients in the grading of gliomas. American Journal of Neuroradiology. 2007;28(9):1693-1699. https://doi.org/10.3174/ajnr.a0674
  16. Kim M, Kim H, Kim J, Cho K, Kim S. Diagnostic accuracy and interobserver variability of pulsed arterial spin labeling for glioma grading. Acta radiol. 2008;49(4):450-457. https://doi.org/10.1080/02841850701881820
  17. Qiao X, Ellingson B, Kim H, Wang D, Salamon N, Linetsky M, Sepahdari A, Jiang B, Tian J, Esswein S, Cloughesy T, Lai A, Nghiemphu L, Pope W. Arterial Spin-Labeling Perfusion MRI Stratifies Progression-Free Survival and Correlates with Epidermal Growth Factor Receptor Status in Glioblastoma. American Journal of Neuroradiology. 2014;36(4):672-677. https://doi.org/10.3174/ajnr.a4196
  18. Toth R, Warfel N. Strange Bedfellows: Nuclear Factor, Erythroid 2-Like 2 (Nrf2) and Hypoxia-Inducible Factor 1 (HIF-1) in Tumor Hypoxia. Antioxidants. 2017;6(2):27. https://doi.org/10.3390/antiox6020027
  19. Wolf R, Wang J, Wang S, Melhem E, O’Rourke D, Judy K, Detre J. Grading of CNS neoplasms using continuous arterial spin labeled perfusion MR imaging at 3 Tesla. Journal of Magnetic Resonance Imaging. 2005;22(4):475-482. https://doi.org/10.1002/jmri.20415
  20. Mayer A, Schneider F, Vaupel P, Sommer C, Schmidberger H. Differential expression of HIF-1 in glioblastoma multiforme and anaplastic astrocytoma. Int J Oncol. 2012;41(4):1260-1270. https://doi.org/10.3892/ijo.2012.1555
  21. Warmuth C, Günther M, Zimmer C. Quantification of Blood Flow in Brain Tumors: Comparison of Arterial Spin Labeling and Dynamic Susceptibility-weighted Contrast-enhanced MR Imaging. Radiology. 2003;228(2):523-532. https://doi.org/10.1148/radiol.2282020409
  22. Pronin IN, Fadeeva LM, Podoprigora AE, Zakharova NE, Serkov SV, Rodionov PV, Shults EI, Korshunov AE, Usachev DYu, Lukshin VA, Celik A, Potapov AA, Kornienko VN. Arterial spin labeling(ASL): method of cerebral blood flow visualization and quantification. Diagnostic Radiology and Radiotherapy. 2012;3(3):64-78. (In Russ.)
  23. Fernández-Seara M, Edlow B, Hoang A, Wang J, Feinberg D, Detre J. Minimizing acquisition time of arterial spin labeling at 3T. Magn Reson Med. 2008;59(6):1467-1471. https://doi.org/10.1002/mrm.21633
  24. Garcia DM, De Bazelaire C, Alsop D. Pseudo-continuous flow driven adiabatic inversion for arterial spin labeling. Proc Int Soc Magn Reson Med. 2005;13:37.
  25. Wong E. New developments in arterial spin labeling pulse sequences. NMR Biomed. 2013;26(8):887-891. https://doi.org/10.1002/nbm.2954
  26. Lin Y, Li J, Zhang Z, Xu Q, Zhou Z, Zhang Z, Zhang Y, Zhang Z. Comparison of Intravoxel Incoherent Motion Diffusion-Weighted MR Imaging and Arterial Spin Labeling MR Imaging in Gliomas. Biomed Res Int. 2015;2015:1-10. https://doi.org/10.1155/2015/234245
  27. Ma H, Wang Z, Xu K, Shao Z, Yang C, Xu P, Liu X, Hu C, Lu X, Rong Y. Three-dimensional arterial spin labeling imaging and dynamic susceptibility contrast perfusion-weighted imaging value in diagnosing glioma grade prior to surgery. Exp Ther Med. 2017;13(6):2691-2698. https://doi.org/10.3892/etm.2017.4370
  28. Xiao H, Chen Z, Lou X, Wang Y, Gui Q, Wang Y, Shi K, Zhou Z, Zheng D, Wang D, Ma L. Astrocytic tumour grading: a comparative study of three-dimensional pseudocontinuous arterial spin labelling, dynamic susceptibility contrast-enhanced perfusion-weighted imaging, and diffusion-weighted imaging. Eur Radiol. 2015;25(12):3423-3430. https://doi.org/10.1007/s00330-015-3768-2
  29. Zeng Q, Jiang B, Shi F, Ling C, Dong F, Zhang J. 3D Pseudocontinuous Arterial Spin-Labeling MR Imaging in the Preoperative Evaluation of Gliomas. American Journal of Neuroradiology. 2017;38(10):1876-1883. https://doi.org/10.3174/ajnr.a5299
  30. Jiang J, Zhao L, Zhang Y, Zhang S, Yao Y, Qin Y, Wang CY, Zhu W. Comparative analysis of arterial spin labeling and dynamic susceptibility contrast perfusion imaging for quantitative perfusion measurements of brain tumors. International Journal of Clinical and Experimental Pathology. 2014;7(6):2790-2799.
  31. Roy B, Gupta R, Maudsley A, Awasthi R, Sheriff S, Gu M, Husain N, Mohakud S, Behari S, Pandey C, Rathore R, Spielman D, Alger J. Utility of multiparametric 3-T MRI for glioma characterization. Neuroradiology. 2013;55(5):603-613. https://doi.org/10.1007/s00234-013-1145-x
  32. Hirai T, Kitajima M, Nakamura H, Okuda T, Sasao A, Shigematsu Y, Utsunomiya D, Oda S, Uetani H, Morioka M, Yamashita Y. Quantitative Blood Flow Measurements in Gliomas Using Arterial Spin-Labeling at 3T: Intermodality Agreement and Inter- and Intraobserver Reproducibility Study. American Journal of Neuroradiology. 2011;32(11):2073-2079. https://doi.org/10.3174/ajnr.a2725
  33. Reginster P, Martin B, Denolin V. Comparative study of pseudo-continuous arterial spin labeling and dynamic susceptibility contrast imaging at 3.0 Tesla in brain tumors. Neurooncol Open Access. 2017;2:1. https://doi.org/10.21767/2572-0376.100018
  34. Yang S, Zhao B, Wang G, Xiang J, Xu S, Liu Y, Zhao P, Pfeuffer J, Qian T. Improving the Grading Accuracy of Astrocytic Neoplasms Noninvasively by Combining Timing Information with Cerebral Blood Flow: A Multi-TI Arterial Spin-Labeling MR Imaging Study. American Journal of Neuroradiology. 2016;37(12):2209-2216. https://doi.org/10.3174/ajnr.a4907
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