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Nikitin K.V.

Burdenko Neurosurgical Institute, Moscow, Russia

Potapov A.A.

NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva

Piskunov A.K.

Burdenko Neurosurgical Institute, Moscow, Russia

Cellular and molecular mechanisms of radiation-induced brain injury: can peripheral markers be detected?

Authors:

Nikitin K.V., Potapov A.A., Piskunov A.K.

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Journal: Burdenko's Journal of Neurosurgery. 2015;79(1): 90‑96

DOI: 10.17116/neiro201579190-96

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CELLULAR AND MOLECULAR MECHANISMS OF RADIATION-INDUCED BRAIN INJURY: CAN PERIPHERAL MARKERS BE DETECTED?
CELLULAR AND MOLECULAR MECHANISMS OF RADIATION-INDUCED BRAIN INJURY: CAN PERIPHERAL MARKERS BE DETECTED?

To cite this article:

Nikitin KV, Potapov AA, Piskunov AK, Nikitin KV, Potapov AA. Cellular and molecular mechanisms of radiation-induced brain injury: can peripheral markers be detected? Burdenko's Journal of Neurosurgery. 2015;79(1):90‑96. (In Russ., In Engl.)
https://doi.org/10.17116/neiro201579190-96

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Investigation of the mechanisms of radiation-induced brain injury is a relevant fundamental objective of radiobiology and neuroradiology. Damage to the healthy brain tissue is the key factor limiting the application of radiation therapy in patients with nervous system neoplasms. Furthermore, postradiation brain injury can be clinically indiscernible from continued tumor growth and requires differential diagnosis. Thus, there exists high demand for biomarkers of radiation effects on the brain in neurosurgery and radiobiology. These markers could be used for better understanding and quantifying the effects of ionizing radiation on brain tissues, as well as for elaborating personalized therapy. Despite the high demand, biomarkers of radiation-induced brain injury have not been identified thus far. The cellular and molecular mechanisms of the effect of ionizing radiation on the brain were analyzed in this review in order to identify potential biomarkers of radiation-induced injury to nervous tissue.

Keywords:

radiation-induced injury
radiation-induced injury
radiation necrosis
radiation necrosis
radiotherapy
radiotherapy
neuroinflammation
neuroinflammation
differential diagnosis
differential diagnosis
biomarkers
biomarkers

Authors:

Nikitin K.V.

Burdenko Neurosurgical Institute, Moscow, Russia

Potapov A.A.

NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva

Piskunov A.K.

Burdenko Neurosurgical Institute, Moscow, Russia

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