Clinical and prognostic value of inflammatory genetic markers in traumatic brain injury

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The paper analyses the published data about association of polymorphic gene markers of different bioactive agents (interleukins, angiotensin convertase, catechol-O-methyltransferase, dopamine receptors etc.) with traumatic brain injury. Analysis of the entire pool of data concerning clinical and experimental studies of association of different polymorphic markers of candidate genes with outcome of traumatic brain injury allows to conclude that IL 1α and IL 1Β, IL 6, catechol-O-methyltransferase, angiotensin convertase, D2 dopamine receptors in fact play important role in neuroinflammatory response to injury and recovery of the brain ant its functions. Moreover presence or absence of certain polymorphic gene markers differentially influence separate pathogenetic mechanisms of brain injury (e.g., severity of brain edema, cerebral blood flow, cognitive functions). Consequently each of the investigated genes contributes in outcome after traumatic brain injury.

Keywords:

traumatic brain injury

polymorphic gene markers

genome

association

outcome predictors

Authors:

Potapov A.A.

NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva

Iusupova M.M.

FGBU "NII neĭrokhirurgii im. akad. N.N. Burdenko" RAMN

Tenedieva V.D.

NII neĭrokhirurgii im. N.N. Burdenko RAMN, Moskva

Nikitin A.G.

Institut biokhimicheskoĭ fiziki im. N.M. Émanuélia RAN

Nosikov V.V.

Institut biokhimicheskoĭ fiziki im. N.M. Émanuélia RAN

List of references:

Ariza M., Maturin M.D., Junque C. et al. Influence of angiotensinconverting enzyme polymorphism on neuropsychological subacute performance in moderate and severe traumatic brain injury. J Neuropsychiatry Clin Neurosci 2006; 18: 39-44.
Balasubramanian S.P., Azmy I.A.F., Higham S.E. et al. Interleukin gene polymorphisms and breast cancer: a case control study and systematic literature review. BMC Cancer 2006; 6: 188.
Blakemore A.I.F., Tarlow J.K., Cork M.J., Gordon C., Emery P., Duff G.W. Interleukin-1 receptor antagonist gene polymorphism as a disease severity factor in systemic lupus erythematosus. Arthritis Rheum 1994; 37: 1380-1385.
Brull D.J., Montgomery H.E., Sanders J. et al. Interleukin-6 gene -174 g>c and -572 g>c promoter polymorphisms are strong predictors of plasma interleukin-6 levels after coronary artery bypass surgery. Arterioscler Thromb Vasc Biol 2001; 21: 1458-1463.
Crucius J.B.A., Pena A.S., van Osten B.W. et al. Interleukin 1 receptor antagonist gene polymorphism and multiple sclerosis. Lancet 1995; 346: 979-980.
Dardiotis E., Dardioti M., Hadjigeorgiou G.M., Paterakis K. Comment. Surg Neurol 2006; 65: 1: 7-10. Surg Neurol 2006; 66: 3: 334-335.
di Giovine F.S., Takhsh E., Blakemore A.I., Duff G.W. Single base polymorphism at -511 in the human interleukin-1 beta gene (IL1-beta). Hum Mol Genet 1992; 1: 6: 450.
Ewing J.F., Haber S.N., Maines M.D. Normal and heat-induced patterns of expression of heme oxygenase-1 (HSP32) in rat brain: hyperthermia causes rapid induction of mRNA and protein. J Neurochem la ;58: 1140-1149.
Ferrari S.L., Ahn-Luong L., Garnero P., Humphries S.E., Greenspan S.L. Two promoter polymorphisms regulating interleukin-6 gene expression are associated with circulating levels of C-reactive protein and markers of bone resorption in postmenopausal women. J Clin Endocr Metab 2003; 88: 255-259.
Fishman D., Faulds G., Jeffery R., Mohamed-Ali V., Yudkin J.S., Humphries S., Woo P. The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. J Clin Invest 1998; 102: 1369-1376.
Hadjigeorgiou G.M., Paterakis K., Dardiotis E. et al. IL-1RN and IL-1B gene polymorphisms and cerebral hemorrhagic events after traumatic brain injury. Neurology 2005; 65: 1077-1082.
Harding D., Brull D., Humphries S.E., Whitelaw A., Montgomery H., Marlow M. Variation in the interleukin-6 gene is associated with impaired cognitive development in children born prematurely: a preliminary study. Pediatr Res 2005; 58: 117-120.
Harding D.R., Dhamrait S., Devadason D. et al. Does angiotensin-1 converting enzyme genotype influence motor or cognitive development after pre-term birth? J Neuroinflammation 2005; 2: 6.
Harding D.R., Dhamrait S., Whitelaw A., Humphries S.E., Marlow N., Montgomery H.E. Does interleukin-6 genotype influence cerebral injury or developmental progress after preterm birth? Pediatrics 2004; 114: 4: 941-947.
Huang D., Pirskanen R., Hjelmstrom P., Lefvert A.K. Polymorphisms of the IL-1Β and IL-1 receptor antagonist genes are associated with myasthenia gravis. J Neuroimmunol 1998; 81: 76-81.
Hulkkonen J., Pertovaara M., Antonen J., Pasternack A., Hurme M. Elevated interleukin-6 plasma levels are regulated by the promoter region polymorphism of the IL6 gene in primary Sjögren's syndrome and correlate with the clinical manifestations of the disease. Rheumatology (Oxford) 2001; 40: 6: 656-661.
Lipsky R.H., Sparling M.B., Ryan L.M. et al. Association of COMT Val158Met genotype with executive functioning following traumatic brain injury. J Neuropsychiatry Clin Neurosci 2005; 17: 465-471.
Lucas S.M., Rothwell N.J., Gibson R.M. The role of inflammation in CNS injury and disease. Br J Pharmacol 2006; 147: S232-S240.
Maksymowych W.P., Rahman P., Reeve J.P., Gladman D.D., Peddle L., Inman R.D. Association of the IL1 gene cluster with susceptibility to ankylosing spondylitis: an analysis of three Canadian populations. Arthritis Rheum 2006; 54: 3: 974-985.
Mansfield J.C., Holden H., Tarlow J.K. et al. Novel genetic association between ulcerative colitis and the antiinflammatory cytokine interleukin-1 receptor antagonist. Gastroenterology 1994; 106: 637-642.
Martinez-Lucas P., Marino-Cuesta J., Garcia-Olmo D.C. et al. Relationship between the Arg72Pro polymorphism of p53 and outcome for patients with traumatic brain injury. Int Care Med 2005; 31: 1168-1173.
Mayer N.J., Forsyth A., Kantachuvesiri S., Mullins J.J., Fleming S. Association of the D allele of the angiotensin I converting enzyme polymorphism with malignant vascular injury. Mol Pathol 2002; 55: 1: 29-33.
McAllister T.W., Rhodes C.H., Flashman L.A., McDonald B.C., Belloni D., Saykin A.J. Effect of the dopamine D2 receptor Tallele on response latency after mild traumatic brain injury. Am J Psychiatr 2005; 162: 1749-1751.
McDowell T.L., Symons J.A., Ploski R., Forre O., Duff G.W. A genetic association between juvenile rheumatoid arthritis and a novel interleukin-1α polymorphism. Arthritis Rheum 1995; 38: 221-228.
Minambres E., Cemborain A., Sauchez-Velasco P. et al. Correlation between transcranial interleukin-6 gradient and outcome in patients with acute brain injury. Crit Care Med 2003; 31: 933-938.
Nicoll J.A.R., Mrak R.E., Graham D.I. et al. Association of interleukin-1 gene polymorphisms with Alzheimer's disease. Ann Neurol 2000; 47: 365-368.
Osiri M., McNicholl J., Moreland L.W., Bridges S.L.Jr. A novel single nucleotide polymorphism and five probable haplotypes in the 5' flanking region of the IL-6 gene in African-Americans. Genes Immun 1999; 1: 2: 166-167.
Pociot F., Molving J., Wogensen L., Worsaae H., Nerup J. A TaqI polymorphism in the human interleukin-1 beta (IL-1Β) gene correlates with IL-1Β secretion in vitro. Eur J Clin Invest 1992; 22: 396-402.
Smith C.J., Emsley H.C., Gavin C.M. et al. Peak plasma interleukin-6 and other peripheral markers of inflammation in the first week of ischaemic stroke correlate with brain infarct volume, stroke severity and long-term outcome. BMC Neurol 2004; 4: 2.
Takeda A., Onodera H., Sugimoto A. et al. Increased expression of heme oxygenase mRNA in rat brain following transient forebrain ischemia. Brain Res 1994; 666: 120-124.
Tanriverdi T., Uzan M., Sanuz G.Z. et al. Lack of association between the IL1A gene (2889) polymorphism and outcome after head injury. Surg Neurol 2006; 65: 7-10.
Tarlow J.K., Blakemore A.I.F., Lennard A. et al. Polymorphism in human IL-1 receptor antagonist gene intron 2 is caused by variable numbers of an 86-bp tandem repeat. Hum Genet 1993; 91: 403-404.
Turner C.P., Panter S.S., Sharp F.R. Anti-oxidants prevent focal rat brain injury as assessed by induction of heat shock proteins (HSP70, HO-1/HSP32, HSP47) following subarachnoid injections of lysed blood. Brain Res Mol Brain Res 1999; 65: 87-102.
Uzan M., Tanriverdi T., Baykara O. et al. Association between interleukin-1 beta (IL-1beta) gene polymorphism and outcome after head injury: an early report. Acta Neurochir (Wien) 2005; 147: 715-720.
Walston J., Arking D.E., Fallin D., Li T., Beamer B., Xue Q., Ferrucci L., Fried L.P., Chakravarti A. IL-6 gene variation is not associated with increased serum levels of IL-6, muscle, weakness, or frailty in older women. Exp Gerontol 2005; 40: 4: 344-352.
Wilson M., Montgomery H. Impact of genetic factors on outcome from brain injury. Br J Anaesth 2007; 99: 1: 43-48

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