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Rotin D.L.

Moscow Clinical Scientific and Practical Center of Moscow Healthcare Department, Moscow, Russia

Clinico-morphological and molecular-biological aspects of cerebral metastases development

Authors:

Rotin D.L.

More about the authors

Journal: Burdenko's Journal of Neurosurgery. 2012;76(2): 70‑76

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To cite this article:

Rotin DL. Clinico-morphological and molecular-biological aspects of cerebral metastases development. Burdenko's Journal of Neurosurgery. 2012;76(2):70‑76. (In Russ.)

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References:

  1. Arnold S.M., Young A.B., Munn R.K. et al. Expession of p53, bcl-2, E-cadherin, matrix metalloproteinase-1 and tissue inhibitor of metalloproteinases-1 in paired primary tumors and brain metastasis. Clin Cancer Res 1999; 5 : 12: 4028-4033.
  2. Attwell S., Roskelly C., Dedhar S. The integrin-linked kinase (ILK) suppresses anoikis. Oncogene 2000; 19: 33: 3811-3815.
  3. Al-Shamy G., Sawaya R. Management of brain metastases: the indispensable role of surgery. J Neurooncol 2009; 92: 275-282.
  4. Barnholz-Sloan J.S., Sloan A.E., Lai P. et al. Incidence proportions of brain metastases in patients diagnosed (1973 to 2001) in the metropolitan Detroit cancer surveillance system. J Clin Oncol 2004; 22: 14: 2865-2872.
  5. Barone T.A., Plunkett R.J., Hohmann P. et al. An experimental model of human leukemic meningitis in the nude rat. Blood 1997; 90: 1: 298-305.
  6. Bartelt S., Lutterbach J. Brain metastases in patients with cancer of unknown primary. J Neurooncol 2003; 64: 3: 249-253.
  7. Bergers G., Benjamin L.E. Tumorigenesis and the angiogenic switch. Nat Rev Cancer 2003; 3: 6: 401-410.
  8. Borsing L., Wong R., Hynes R.O. et al. Synergistic effects of L- and P- selectin in fascillating tumor metastasis can involve non-mucin ligands and implicate leukocytes as enhancers of metastasis. Proc Natl Acad Sci USA 2002; 99: 4: 2193-2198.
  9. Bouffet E., Doumi N., Thiesse P. et al. Brain metastases in children with solid tumors. Cancer 1997; 79: 2: 403-410.
  10. Breneman J.C., Steinmetz R., Smith A. et al. Frameless image-guided intracranial stereotactic radiosurgery: clinical outcomes for brain metastases. Int J Radiat Oncol Biol Phys 2009; 74: 3: 702-706.
  11. Braun S., Vogl F.D., Naume B. et al. A pooled analysis of bone marrow micrometastasis in breast cancer. N Engl J Med 2005; 353: 793-802.
  12. Brayton J., Qing Z., Hart M.N. et al. Influence of adhesion molecule expression by human brain microvessel endothelium on cancer cell adhesion. J Neuroimmunol 1998; 89: 1-2: 104-112.
  13. Brennan S.M., Gregory D.L., Stillie A. et al. Should extrapulmonary small cell cancer be managed like small cell lung cancer? Cancer 2010; 116: 4: 888-895.
  14. Bucholz R.D., Laycock K.A., Cuff L.E. CyberKnife stereotactic radiosurgery forintracranial neoplasms, with a focus on malignant tumors. Technol Cancer Res Treat 2010; 9: 6: 541-550.
  15. Camerer E., Quazi A.A., Duong D.N. et al. Platelets, protease-activated receptors, and fibrinogen in hematogenous metastasis. Blood 2004; 104: 2: 397-401.
  16. Cappuzzo F., Mazzoni F., Maestri A. et al. Medical treatment of brain metastases from solid tumours. Forum (Genova) 2004; 10: 2: 137-148.
  17. Cascino T.L., Leavengood J.M., Kemeny N. et al. Brain metastases from colon cancer. J Neurooncol 1983; 1: 203-209.
  18. Cavallaro U., Christofori G. Cell adhesion in tumor invasion and metastasis: loss of the glue is not enough. Biochim Biophys Acta Rev Cancer 2001; 1552: 1: 39-45.
  19. Chambers A.F., Naumov G.N., Varghese H.J. et al. Critical steps in hematogenous metastasis: an overview. Surg Oncol Clin N Am 2001; 10: 2: 243-255.
  20. Daryanni D., Plukker J.T., de Jong M.A. et al. Increased incidence of brain metastases in cutaneous head and neck melanoma. Melanoma Res 2005; 15: 2: 119-124.
  21. Davis F.G., McCarthy B., Jukich P. The descriptive epidemiology of brain tumors. Neuroimaging Clin N Am 1999; 9: 4: 581-594.
  22. Disibio G., French S.W. Mettastatic patterns of cancers: results from the large autopsy study. Arch Path Lab Med 2008; 132: 931-939.
  23. Douma S., Van L.T., Zevenhoven J. et al. Suppression of anoikis and induction of metastasis by the neurotrophic receptor TrkB. Nature 2004; 430: 7003: 1034-1039.
  24. Ewing J. Metastasis. In: Neoplastic diseases: A Treatise on Tumours. Ed. J. Ewing. Philadelphia: W.B. Saunders 1940; 62-74.
  25. Felding-Habermann B., O'Toole T.E. et al. Integrin activation controls metastasis in human breast cancer. Proc Natl Acad Sci USA 2001; 98: 4: 1853-1858.
  26. Fidler I.J. The pathogenesis of cancer metastasis: The 'seed and soil' hypothesis revisited. Nat Rev Cancer 2003; 3: 6: 453-458.
  27. Fidler I.J. The role of the organ microenvironment in brain metastasis. Semin Cancer Biol 2010.
  28. Fidler I.J., Yano S., Zhang R.D. et al. The seed and soil hypothesis; vascularisation and brain metastases. Lancet Oncol 2002; 3: 1: 53-57.
  29. Fogarty G.B., Tartaguia C. The utility of magnetic resonance imaging in the detection of brain metastases in the staging of cutaneous melanoma. Clin Oncol (R Coll Radiol) 2006; 18: 4: 360-362.
  30. Fogelholm R., Uutela T., Murros K. Epidemiology of the central nervous system neoplasms. A regional survey in Central Finland. Acta Neurol Scand 1984; 69: 129-136.
  31. Foldi M. The brain and the lymphatic system (I). Lymphology 1996; 29: 1: 1-9.
  32. Foldi M. The brain and the lymphatic system (II). Lymphology 1996; 29: 1: 10-14.
  33. Folgueras A.R., Pendas A.M., Sanchez L.M. et al. Matrix metalloproteinases in cancer: from new functions to improved inhibition strategies. Int J Dev Biol 2004; 48: 5-6: 411-424.
  34. Follmore C.M., Kuperwasser C. Human breast cancer cell lines contain stem-like cells that self renew. Breast Cancer Res 2008; 140: 62-73.
  35. Folkman J. How is blood vessel growth regulated in normal and neoplastic tissue? G.H.A. Clower Memorial Award Lecture. Cancer Res 1986; 46: 467-473.
  36. Folkman J., Klagsbrun M. Angiogenic factors. Science 1987; 235: 4787: 442-447.
  37. Friedl P., Wolf K. Tumour-cell invasion and migration: diversity and escape mechanisms. Nat Rev Cancer 2003; 3: 5: 362-374.
  38. Gabos Z., Sinha R., Hanson J. et al. Prognostic significance of human epidermal growth factor receptor positivity for the development of the brain metastasis after newly diagnosed breast cancer. J Clin Oncol 2006; 20: 24: 36: 5658-5663.
  39. Gavrilovic I.T., Posner J.B. Brain metastases: epidemiology and pathophisiology. J Neurooncol 2005; 75: 1: 5-14.
  40. Gupta R.A., Shah N., Wang K.C. et al. Long-non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature 2010; 464: 1071-1076.
  41. Guomundsson K.R. A survey of tumours of the central nervous system in Iceland during 10-year period 1954-1963. Acta Neurol Scand 1970; 46: 538-552.
  42. Harisi R., Kenessey I., Olah J.N. et al. Differential inhibition of single and cluster type tumor cell migration. Anticancer Res 2009; 29: 8: 2981-2985.
  43. Harabin-Slowinska M., Slowinski J., Konecki J. et al. Expression of adhesion molecule CD44 in metastatic brain tumors. Folia Neuropathol 1998; 36: 3: 179-184.
  44. Hay E.D. The mesenchimal cell, its role in the ebryo, and the remarkable signaling mechanisms that create it. Dev Dyn 2005; 233: 3: 706-720.
  45. He B.P., Wang J.J., Zhang X. et al. Differential reactions of microglia to brain metastasis of lung cancer. Mol Med 2006; 12: 7-8: 161-170.
  46. Hedley B.D., Allan A.L., Chambers A.F. Tumor dormancy and the role of metastasis suppressor genes in regulating ectopic growth. Future Oncol 2006; 2: 5: 627-641.
  47. Hirohashi S. Inactivation of the E-cadherin-mediated cell adhesion system in human cancers. Am J Pathol 1998; 153: 2: 333-339.
  48. Hirshberg A., Leibovich P., Horowitz I. et al. Metastatic tumors to post-extraction sites. J Oral Maxillofac Surg 1993; 51: 12: 1334-1337.
  49. Hutter A., Schwetye K.E., Bierhals A.J. et al. Brain neoplasms: epidemiology, diagnosis, and prospects for cost-effective imaging. Neuroimaging Clin N Am 2003; 13: 2: 237-242.
  50. Hwang Close T.P., Grego J.M. et al. Predilection of brain metastasis and gray and white matter junction and vascular border zones. Cancer 1996; 77: 8: 1551-1555.
  51. Jaalinoja J., Herva R., Korpela M. et al. Matrix metalloproteinase 2 (MMP-2) immunoreactive protein is associated with poor grade and survival in brain neoplasms. J Neurooncol 2000; 46: 1: 81-90.
  52. Jain R.K., Duda D.G., Willett C.G. et al. Biomarkers of response and resistance to antioangionetic therapy. Nat Rev Clin Oncol 2009; 6: 327-338.
  53. Johnston M., Zakharov A., Papaiconomou C. et al. Evidence of connections between cerebrospinal fluid and nasal lymphatic vessels in humans, nonhuman primates and other mammalian species. Cerebrospinal Fluid Res 2004; 1: 1: 2.
  54. Joyce J.A., Joyce J.A., Pollard J.W. Microenvironmental regulation of metastasis. Nat Rev Cancer 2009; 9: 4: 239-252.
  55. Kamar F.G., Posner J.B. Brain metastases. Semin Neurol 2010; 30: 3: 217-235.
  56. Klein C.A., Blankenstein T.J., Schmidt-Kittler O. et al. Genetic heterogeneity of single disseminated tumour cells in minimal residual cancer. Lancet 2002; 360: 9334: 683-689.
  57. Knopf P.M., Cserr H.F., Nolan S.C. et al. Physiology and immunology of lymphatic drainage of interstitial and cerebrospinal fluid from the brain. Neuropathol Appl Neurobiol 1995; 21: 175-180.
  58. Koh L., Zakharov A., Johnston M. Integration of the subarachnoid space and lymphatics: is it time to embrace a new concept of cerebrospinal fluid absorption? Cerebrospinal Fluid Res 2005; 20: 2: 6.
  59. Kosir M.A., Wang W., Zukowski K.L. et al. Degradation of basement membrane by prostate tumor heparanase. J Surg Res 1999; 81: 1: 42-47.
  60. Larcos M.G., Maisey M.N. FDG-PET screening for cerebral metastases in patients with suspected malignancy. Nucl Med Commun 1996; 17: 3: 197-198.
  61. Larue L., Bellacosa A. Epithelial-mesenchimal transition in development and cancer: role of phosphatidylnositol 3' kinase/AKT pathways. Oncogene 2005; 24: 50: 7443-7454.
  62. Lassman A.B., DeAngelis L.M. Brain metastases. Neurol Clin 2003; 21: 1: 1-23.
  63. Lee J.M., Dedhar S., Kalluri R. et al. The epithelial-mesenchimal transition: new insights in signaling, development, and disease. J Cell Biol 2006; 172: 7: 973-981.
  64. Li G., Sathyamoorthy K., Herlyn M. N-cadherin-mediated intracellular interactions promote survival and migration of melanoma cells. Cancer Res 2001; 61: 9: 3819-3825.
  65. Luzzi K.J., MacDonald I.C., Schmidt E.E. et al. Multistep nature of metastatic inefficiency - Dormancy of solitary cells after successful extravasation and limited survival of early micrometastases. Am J Pathol 1998; 153: 3: 865-873.
  66. Machein M.R., Plate K.H. VEGF in brain tumors. J Neurooncol 2000; 50: 1-2: 109-120.
  67. Marusyk A., Polyak. et al. Tumor heterogeneity: causes and consequences. Biochim Biophis Acta 2010; 1805: 105-117.
  68. McDonald D.M., Baluk P. Significance of blood vessel leakiness in cancer. Cancer Res 2002; 62: 18: 5381-5385.
  69. Madajewicz S., Karakousis C., West C.R. et al. Malignant melanoma brain metastases: Review of Roswell Park Memorial Institute experience. Cancer 1984; 53: 11: 2550-2552.
  70. Moon K.S., Jung S., Lee M.C. et al. Metastatic glioblastoma in cervical lymph node after repeated craniotomies: report of a case with diagnosis by fine needle aspiration. J Korean Med Sci 2004; 19: 6: 911-914.
  71. Nathoo N., Chahlavi A., Bamett G.H. et al. Pathobiology of brain metastases. J Clin Pathol 2005; 58: 3: 237-242.
  72. Nielson S.L., Posner J.B. Brain metastasis localized to an area of infarction. J Neurooncol 1983; 1: 191-195.
  73. Nieman M.T., Prudoff R.S., Johnson K.R. et al. N-cadherin promotes motility in human breast cells regardless of their E-cadherin expression. J Cell Biol 1999; 147: 3: 631-644.
  74. Nishizaki T., Saito K., Jimi Y. et al. The role of cyberknife radiosurgery/ radiotherapy for brain metastases of multiple or large-size tumors. Minim Inv Neurosurg 2006; 49: 4: 203-209.
  75. Nussbaum E.S., Djalilian H.R., Cho K.H. et al. Brain metastases- Histology, multiplicity, surgery, and survival. Cancer 1996; 78: 8: 1781-1788.
  76. Paget S. The distribution of secondary growths in cancer of the breast. Cancer Metastasis Rev 1989; 8: 2: 98-101.
  77. Pantel K., Brakenhoff R.H. Dissecting the metastatic cascade. Nat Rev Cancer 2004; 4: 6: 448-456.
  78. Pasqualini R., Arap W. Profiling the molecular diversity of blood vessels. Cold Spring Harb Symp Quant Biol 2002; 67: 223-225.
  79. Patchell R.A., Tibbs P.A., Walsh J.W. A randomized trial of surgery in the treatment of single metastases to the brain. N Engl J Med 1990; 322: 494-500.
  80. Percy A.K., Elveback L.R., Okazaki H. et al. Neoplasms of the central nervous system. Epidemiologic considerations. Neurology 1972; 22: 40-48.
  81. Pickern J.W., Lopez G., Tsukada Y. et al. Brain metastases: An autopsy study. Cancer Treat Symp 1983; 2: 295-313.
  82. Polyzidosis K.S., Miliaris G., Pavlidis N. Brain metastases of unknown primary: a diagnostic and therapeutic dilemma. Cancer Treat Rev 2005; 31: 4: 247-255.
  83. Poon R.T., Fan S.T., Wong J. Clinical implications of circulating angiogenic factors in cancer patients. J Clin Oncol 2001; 19: 4: 1207-1225.
  84. Posner J.B., Chernik N.L. Intracranial metastases from systemic cancer. Adv Neurol 1978; 19; 575-587.
  85. Posner J.B. Neurologic complications of Cancer. Philadelphia: F.A. Davis 1995.
  86. Puduvalli V.K. Brain metastases: biology and the role of the brain microenviroment. Curr Oncol Rep 2001; 3: 6: 467-475.
  87. Schouten L.J., Rutten J., Huveneers H.A.M. et al. Incidence of brain metastases in a cohort of patients with carcinoma of the breast, colon, kidney, and lung and melanoma. Cancer 2002; 94: 10: 2698-2705.
  88. Schulenburg A., Ulrich-Pur H., Thurner D. et al. Neoplastic stem cells: A novel therapeutic target in clinical oncology. Cancer 2006; 107: 10: 2512-2520.
  89. Seute T., Leffers P., Willmink J.T. Response of asymptomatic brain metastases from small-cell lung cancer to systemic first-line chemotherapy. J Clin Oncol 2006; 243: 13: 2079-2083.
  90. Shojania K.G., Burton E.C., McDonald K.M. et al. Changes in rates of autopsy-detected diagnostic error over time: a systematic review. JAMA 2003; 289: 21: 2849-2856.
  91. Sleeman J., Steeg P.S. Cancer metastasis as a therapeutic target. Eur J Cancer 2010; 46: 7: 1177-1180.
  92. Steeg P.S., Theodorescu D. Metastasis: a therapeutic target for cancer. Nat Clin Pract Oncol 2008; 5: 4: 206-219.
  93. Sugarbaker E.V. Cancer metastasis: a product of tumor-host interactions. Curr Probl Cancer 1979; 3: 7: 1-59.
  94. Tarin D., Price J.E., Kettlewell M.G. et al. Mechanisms of human tumor metasatasis studied in patients with peritonovenous shunts. Cancer Res 1984; 44: 8: 3584-3592.
  95. Tham Y.L., Sexton K., Kramer R. et al. Primary breast cancer phenotypes associated with propensity for central nervous system metastases. Cancer 2006; 107: 4: 696-704.
  96. Trepel M., Pasqualini R., Arap W. Chapter 4. Screening phage-display Peptide libraries for vascular targeted peptides. Methods Enzymol 2008; 445: 83-106.
  97. Valastyan S., Reinhardt F., Benaich N. A pleiotropically acting microRNA inhibits breast cancer metastasis. Cell 2009; 137; 1032-1046.
  98. Van Schil P.E., Hendriks J.M., Carp L., Lauwers P.R. Surgery for oligometastatic disease in non-small-cell lung cancer. Exp Rev Anticancer Ther 2008; 8: 12: 1931-1938.
  99. Walker A.E., Robbins M., Weinfield F.D. Epidemiology of brain tumors: The national survey of intracranial neoplasms. Neurology 1985; 35: 219-226.
  100. Weiss L. Comments on hematogenous metastatic patterns in human as revealed by autopsy. Clin Exp Metastasis 1992; 10: 191-199.
  101. Wyckoff J.B., Wang Y., Lin E.Y. et al. Direct visualization of macrophage-assisted tumor cell intravasation in mammary tumors. Cancer Res 2007; 67: 6: 2649-2656.

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