Post-resection defects in the treatment of breast cancer require the development of safe and effective methods for their correction. Current approaches are often associated with limitations, which drives further research and the creation of new implantable materials. A heterogeneous collagen-containing composition (HCCC) represents a promising material for improving healing and preventing recurrence; however, its effect on tumor growth dynamics and metastasis remains insufficiently studied.

OBJECTIVE

To assess the impact of HCCC on tumor growth dynamics and the frequency of metastasis in an experimental 4T1 breast cancer model in mice.

METHODS

The experiment was conducted on mice divided into groups receiving injections of HCCC or saline solution. During the 43-day observation period, the size and mass of tumor nodules, as well as the frequency of metastasis to the lungs and regional lymph nodes, were assessed. Histological analysis of tissues was also performed to evaluate the effect of HCCC on tumor tissue and its microenvironment.

RESULTS

In some cases, encapsulation of the material in surrounding tissues was observed in the groups with HCCC administration; however, HCCC was not detected in the groups with surgical intervention on the primary tumor. The frequency and degree of metastasis inhibition did not differ between the experimental and control groups. Statistical analysis revealed no significant differences in tumor growth dynamics and metastasis.

CONCLUSION

The use of HCCC did not have a significant impact on the tumor process or metastasis in this breast cancer model. The results indicate a neutral effect of HCCC, which may be beneficial for further research on biocompatible implantable materials.