The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Pervushina E.V.

Bashkir state medical university

Kutlubaev M.A.

Bashkir State Medical University

Kuznetsova D.R.

Bashkir State Medical University

Karimova G.I.

Bashkir State Medical University

Kachemaeva O.V.

Bashkir State Medical University

Mkhitaryan E.A.

Pirogov Russian National Research Medical University;
Russian Clinical and Research Center of Gerontology Pirogov — Russian National Research Medical University

Combination of amyotrophic lateral sclerosis with Alzheimer’s disease

Authors:

Pervushina E.V., Kutlubaev M.A., Kuznetsova D.R., Karimova G.I., Kachemaeva O.V., Mkhitaryan E.A.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2026;126(1): 132‑136

DOI: 10.17116/jnevro2026126011132

Read: 490 times

Buy for 300₽
Contact the author
Table of contents

COMBINATION OF AMYOTROPHIC LATERAL SCLEROSIS WITH ALZHEIMER’S DISEASE
COMBINATION OF AMYOTROPHIC LATERAL SCLEROSIS WITH ALZHEIMER’S DISEASE

To cite this article:

Pervushina EV, Kutlubaev MA, Kuznetsova DR, Karimova GI, Kachemaeva OV, Mkhitaryan EA. Combination of amyotrophic lateral sclerosis with Alzheimer’s disease. S.S. Korsakov Journal of Neurology and Psychiatry. 2026;126(1):132‑136. (In Russ.)
https://doi.org/10.17116/jnevro2026126011132

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
МСФ на ЯМ
Использование инфографики авторами научных работ
Recommended articles:
Cyto­kine status of patients with Alzheimer’s disease. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(4-2):5-12
The main mechanisms of deve­lopment of cognitive impairment. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(4-2):13-18
Curcumin-induced increased reti­nal fluorescence as a new method in the early diagnosis of Alzheimer’s disease. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(4-2):19-25
Differential diagnosis of Alzheimer’s disease and vascular cognitive diso­rders. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(4-2):26-35
A comprehensive study of Alzheimer’s disease biomarkers in plasma and cere­brospinal fluid. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(4-2):43-53
Prospects for treating Alzheimer’s disease. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(4-2):54-60
Cognitive impairment in patients with multiple scle­rosis. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(4-2):67-73
Cognitive impairment after major surgical operations. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(4-2):74-80
Analysis of cognitive status in patients with different noso­logies and clinical variants of very late mani­festing schi­zophreniform psychosis. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(4-2):88-93
Prevalence and characteristics of risk factors for cere­brovascular disease in overweight. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(5):118-124
Abstract:

The combination of amyotrophic lateral sclerosis (ALS) with Alzheimer’s disease is rare. Currently, it is unclear whether such comorbidity is an accidental coincidence or a manifestation of a specific pathological process. A case of simultaneous occurrence of classic symptoms of the bulbar form of ALS and Alzheimer’s disease is presented. The possible mechanisms of the combination of two diseases are analyzed.

Keywords:

amyotrophic lateral sclerosis
motor neuron disease
Alzheimer’s disease
cognitive impairment

Authors:

Pervushina E.V.

Bashkir state medical university

Kutlubaev M.A.

Bashkir State Medical University

Kuznetsova D.R.

Bashkir State Medical University

Karimova G.I.

Bashkir State Medical University

Kachemaeva O.V.

Bashkir State Medical University

Mkhitaryan E.A.

Pirogov Russian National Research Medical University;
Russian Clinical and Research Center of Gerontology Pirogov — Russian National Research Medical University

Received:

30.05.2025

Accepted:

07.06.2025

Close metadata

References:

  1. Goutman SA, Hardiman O, Al-Chalabi A, et al. Recent advances in the diagnosis and prognosis of amyotrophic lateral sclerosis. Lancet Neurol. 2022;21(5):480-493.  https://doi.org/10.1016/S1474-4422(21)00465-8
  2. Kutlubaev MA, Pervushina EV, Areprintceva DK, et al. Neuropsychiatric presentations of amyotrophic lateral sclerosis. S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(5):36-42. (In Russ.). https://doi.org/10.17116/jnevro202212205136
  3. Koberskaya NN, Grishina DA, Yakhno NN. Syndrome amyotrophic lateral sclerosis — Alzheimer’s dementia. Rossijskij Nevrologicheskiy Zhurnal. 2021;26(2):17-24. (In Russ.). https://doi.org/10.30629/2658-7947-2021-26-2-17-24
  4. Verde F, Aiello EN, Adobbati L, et al. Coexistence of Amyotrophic Lateral Sclerosis and Alzheimer’s Disease: Case Report and Review of the Literature. J Alzheimers Dis. 2023;95(4):1383-1399. https://doi.org/10.3233/JAD-230562
  5. Cedarbaum JM, Stambler N, Malta E, et al. The ALSFRS-R: a revised ALS functional rating scale that incorporates assessments of respiratory function. BDNF ALS Study Group (Phase III). J Neurol Sci. 1999;169(1-2):13-21.  https://doi.org/10.1016/s0022-510x(99)00210-5
  6. Brylev L, Demeshonok VS, Ataulina AI, et al. Validity and reliability of the Russian version of the revised Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS-R). Neurol Sci. 2024;45(1):187-189.  https://doi.org/10.1007/s10072-023-06979-3
  7. Kutlubaev MA, Areprintseva DK, Radakovic R, et al. Psychometric properties of the Russian version of the Edinburgh cognitive and behavioral amyotrophic lateral sclerosis screen. Amyotroph Lateral Scler Frontotemporal Degener. 2024;25(7-8):785-787.  https://doi.org/10.1080/21678421.2024.2328579
  8. Davis DH, Creavin ST, Yip JL, et al. Montreal Cognitive Assessment for the detection of dementia. Cochrane Database Syst Rev. 2021;7(7):CD010775. https://doi.org/10.1002/14651858
  9. Bjelland I, Dahl AA, Haug TT, et al. The validity of the Hospital Anxiety and Depression Scale. An updated literature review. J Psychosom Res. 2002;52(2):69-77.  https://doi.org/10.1016/s0022-3999(01)00296-3
  10. Turner MR. UK MND Clinical Studies Group. Diagnosing ALS: the Gold Coast criteria and the role of EMG. Pract Neurol. 2022;22(3):176-178.  https://doi.org/10.1136/practneurol-2021-003256
  11. Meneses A, Koga S, O’Leary J, et al. TDP-43 Pathology in Alzheimer’s Disease. Mol Neurodegener. 2021;16(1):84.  https://doi.org/10.1186/s13024-021-00503-x
  12. Pervushina EV, Kutlubaev MA, Kachemaeva OV, et al. Comorbidity of amyotrophic lateral sclerosis with the symptoms of progressive supranuclear palsy. Rossijskij Nevrologicheskiy Zhurnal. 2025;30(1):40-45. (In Russ.). https://doi.org/10.30629/2658-7947-2025-30-1-40-45
  13. Robinson JL, Geser F, Corrada MM, et al. Neocortical and hippocampal amyloid-β and tau measures associate with dementia in the oldest-old. Brain. 2011;134(Pt 12):3708-3715. https://doi.org/10.1093/brain/awr308
  14. Bond S, Saxena S, Sierra-Delgado JA. Microglia in ALS: Insights into Mechanisms and Therapeutic Potential. Cells. 2025;14(6):421.  https://doi.org/10.3390/cells14060421
  15. Kutlubaev MA, Hardy TA, Areprintseva DK, et al. Comorbid amyotrophic lateral sclerosis and sarcoidosis. Acta Neurol Belg. 2023;123(2):709-710.  https://doi.org/10.1007/s13760-022-02016-w
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.