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Chutko L.S.

N.P. Bechtereva Institute of the Human Brain of the Russian Academy of Sciences;
Saint-Petersburg State Pediatric Medical University

Surushkina S.Yu.

N. Bekhtereva Institute of Human Brain Russian Academy of Sciences

Yakovenko E.A.

N. Bekhtereva Institute of Human Brain Russian Academy of Sciences

Shcheglova L.V.

St. Petersburg State Pediatric Medical University

Mirzaeva L.M.

Mechnikov´s North-Western State Medical University

Cognitive impairment in asthenic disorders

Authors:

Chutko L.S., Surushkina S.Yu., Yakovenko E.A., Shcheglova L.V., Mirzaeva L.M.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2025;125(3): 27‑32

DOI: 10.17116/jnevro202512503127

Views: 392

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Table of contents

COGNITIVE IMPAIRMENT IN ASTHENIC DISORDERS
COGNITIVE IMPAIRMENT IN ASTHENIC DISORDERS

To cite this article:

Chutko LS, Surushkina SYu, Yakovenko EA, Shcheglova LV, Mirzaeva LM. Cognitive impairment in asthenic disorders. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;125(3):27‑32. (In Russ.)
https://doi.org/10.17116/jnevro202512503127

Подписка 2025-2 (S.S. Korsakov Journal of Neurology and Psychiatry)
 
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The article presents a review of scientific publications devoted to cognitive aspects of asthenic disorders. The authors present different views on the etiology and basic mechanisms of pathogenesis of psychogenic asthenia and chronic fatigue syndrome, current diagnostic criteria for these diseases. The main attention is paid to the consideration of the neurocognitive deficit observed in mental asthenia and chronic fatigue syndrome. The role of cognitive control impairment in the development of adaptation disorders and the formation of asthenic conditions is considered. The results of studies of the effectiveness of pharmacological therapy for asthenic disorders are presented.

Keywords:

asthenia
neurasthenia
chronic fatigue syndrome
cognitive fatigue
citicoline
recognan

Authors:

Chutko L.S.

N.P. Bechtereva Institute of the Human Brain of the Russian Academy of Sciences;
Saint-Petersburg State Pediatric Medical University

Surushkina S.Yu.

N. Bekhtereva Institute of Human Brain Russian Academy of Sciences

Yakovenko E.A.

N. Bekhtereva Institute of Human Brain Russian Academy of Sciences

Shcheglova L.V.

St. Petersburg State Pediatric Medical University

Mirzaeva L.M.

Mechnikov´s North-Western State Medical University

Received:

19.02.2025

Accepted:

05.03.2025

List of references:

  1. Ukhtomskii AA. Izbrannye trudy. Leningrad: Nauka. 1978. (In Russ.).
  2. Boksem MA, Tops M. Mental fatigue: costs and benefits. Brain Res Rev. 2008;59(1):125-139.  https://doi.org/10.1016/j.brainresrev.2008.07.001
  3. Langner R, Eickhoff SB, Steinborn MB. Mental fatigue modulates dynamic adaptation to perceptual demand in speeded detection. PLoS One. 2011;6(12):e28399. https://doi.org/10.1371/journal.pone.0028399
  4. Velichkovskii BB. Kognitivnye effekty umstvennogo utomleniya. Vestnik Moskovskogo universiteta. Seriya 14. Psikhologiya. 2019;1:108-122. (In Russ.).
  5. Kunasegaran K, Ismail AMH, Ramasamy S, et al. Understanding mental fatigue and its detection: a comparative analysis of assessments and tools. Peer J. 2023;11:e15744. https://doi.org/10.7717/peerj.15744
  6. Kuppuswamy A. Role of selective attention in fatigue in neurological disorders. Eur J Neurol. 2023;30(5):1453-1458. https://doi.org/10.1111/ene.15739
  7. Desmond PA, Hancock PA. Active and Passive Fatigue States. In: Hancock PA, Desmond PA, Eds. Stress, Workload, and Fatigue. CRC Press, Boca Raton. 2001;455-465.  https://doi.org/10.1201/b12791-3.1
  8. Ma J, Gu J, Jia H, et al. The Relationship Between Drivers’ Cognitive Fatigue and Speed Variability During Monotonous Daytime Driving. Front Psychol. 2018;9:459.  https://doi.org/10.3389/fpsyg.2018.00459
  9. Yoon JH, Park NH, Kang YE, et al. The demographic features of fatigue in the general population worldwide: a systematic review and meta-analysis. Front Public Health. 2023;11:1192121. https://doi.org/10.3389/fpubh.2023.1192121
  10. Titova NV, Bezdol’nyi YuN, Katunina EA. Asteniya, psikhicheskaya utomlyaemost’ i kognitivnaya disfunktsiya. SS. Korsakov Journal of Neurology and Psychiatry. 2023;123(5):38-47. (In Russ.). https://doi.org/10.17116/jnevro202312305138
  11. Grossi G, Perski A, Osika W, Savic I. Stress-related exhaustion disorder — clinical manifestation of burnout? A review of assessment methods, sleep impairments, cognitive disturbances, and neuro-biological and physiological changes in clinical burnout. Scand J Psychol. 2015;56(6):626-636.  https://doi.org/10.1111/sjop.12251
  12. Vorob’eva OV. Mnogogrannost’ fenomena astenii. RMZH. 2012;5:248. (In Russ.).
  13. Lutskii IS, Lutskii EI. Vliyanie khronicheskogo psikhoemotsional’nogo napryazheniya na kognitivnye funktsii. Kazanskii meditsinskii zhurnal. 2015;96(4):523-531. (In Russ.). https://doi.org/10.17750/KMJ2015-523
  14. Maercker A, Lorenz L. Adjustment disorder diagnosis: Improving clinical utility. World Journal of Biological Psychiatry. 2018;19(1):3-13.  https://doi.org/10.1080/15622975.2018.1449967
  15. Chutko LS, Surushkina SYu, Yakovenko EA, et al. Klinicheskie osobennosti astenii v ramkakh rasstroistv adaptatsii. S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(7):55-63. (In Russ.). https://doi.org/10.17116/jnevro202112107155
  16. Alekseyev AA, Rupchev GE. The notion of executive functions in psychologicalstudies: perspectives and contradictions. Psihologicheskie issledovanija: jelektron. nauch. zhurn. 2010;3(12). (In Russ.). https://doi.org/10.54359/ps.v3i12.903
  17. Miller EK, Cohen JD. An integrative theory of prefrontal cortex function. Annu Rev Neurosci. 2001;24:167-202.  https://doi.org/10.1146/annurev.neuro.24.1.167
  18. Nelson A, Gavelin HM, Boraxbekk CJ, et al. Subjective cognitive complaints in patients with stress-related exhaustion disorder: a cross sectional study. BMC Psychol. 2021;9(1):84.  https://doi.org/10.1186/s40359-021-00576-9
  19. Zakharov VV, Kabaeva AR. Nedementnye kognitivnye narusheniya: sub»ektivnye, legkie i umerennye. Nervnye bolezni. 2017;4:3-7. (In Russ.).
  20. Gavelin HM, Neely AS, Andersson M, et al. Neural activation in stress-related exhaustion: Cross-sectional observations and interventional efects. Psychiatry Res: Neuroimaging. 2017;269:17-25.  https://doi.org/10.1016/j.pscychresns.2017.08.008
  21. Gavelin HM, Neely AS, Dunås T, et al. Mental fatigue in stress-related exhaustion disorder: Structural brain correlates, clinical characteristics and relations with cognitive functioning. Neuroimage Clin. 2020;27:102337. https://doi.org/10.1016/j.nicl.2020.102337
  22. Podlesek A, Komidar L, Kavcic V. The Relationship Between Perceived Stress and Subjective Cognitive Decline During the COVID-19 Epidemic. Front Psychol. 2021;12:647971. https://doi.org/10.3389/fpsyg.2021.647971
  23. Putilina MV. Asthenic disorders as a manifestation of chronic fatigue syndrome. S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(8):125-130. (In Russ.). https://doi.org/10.17116/jnevro2021121081125
  24. Bested AC, Marshall LM. Review of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: An evidence-based approach to diagnosis and management by clinicians. Rev Environ Health. 2015;30:223-249.  https://doi.org/10.1515/reveh-2015-0026
  25. Clayton EW. Beyond myalgic encephalomyelitis/chronic fatigue syndrome: an IOM report on redefining an illness. JAMA. 2015;313(11):1101-1102. https://doi.org/10.1001/jama.2015.1346
  26. Pietrangelo T, Cagnin S, Bondi D, et al. Myalgic encephalomyelitis/chronic fatigue syndrome from current evidence to new diagnostic perspectives through skeletal muscle and metabolic disturbances. Acta Physiol (Oxf). 2024;240(4):e14122. https://doi.org/10.1111/apha.14122
  27. Arron HE, Marsh BD, Kell DB, et al. Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: the biology of a neglected disease. Front Immunol. 2024;15:1386607. https://doi.org/10.3389/fimmu.2024.1386607
  28. Lim EJ, Son CG. Prevalence of Chronic Fatigue Syndrome (CFS) in Korea and Japan: A Meta-Analysis. J Clin Med. 2021;10(15):3204. https://doi.org/10.3390/jcm10153204
  29. Hilland GH, Anthun KS. Socioeconomic determinants of myalgic encephalomyelitis/chronic fatigue syndrome in Norway: a registry study. BMC Public Health. 2024;24(1):1296. https://doi.org/10.1186/s12889-024-18757-7
  30. Słomko J, Newton JL, Kujawski S, et al. Prevalence and characteristics of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) in Poland: a crosssectional study. BMJ Open.2019;9(3):e023955. https://doi.org/10.1136/bmjopen-2018-023955
  31. Johnston SC, Staines DR, Marshall-Gradisnik SM. Epidemiological characteristics of chronic fatigue syndrome/myalgic encephalomyelitis in Australian patients. Clin Epidemiol. 2016;8:97-107.  https://doi.org/10.2147/CLEP.S96797
  32. Putilina MV. Astenicheskie rasstroistva v obshchemeditsinskoi praktike. Algoritmy diagnostiki i terapii. Nervnye bolezni. 2013;4:26-33. (In Russ.).
  33. Glassford JA. The Neuroinflammatory Etiopathology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Front Physiol. 2017;8:88. 
  34. Unger ER, Lin JS, Wisk LE, et al. Innovative Support for Patients with SARS-CoV-2 Infections Registry (INSPIRE) Group. Myalgic Encephalomyelitis/Chronic Fatigue Syndrome After SARS-CoV-2 Infection. JAMA Netw Open. 2024;7(7):e2423555. https://doi.org/10.1001/jamanetworkopen.2024.23555
  35. Vasenina EE, Gan’kina OA, Levin OS. Stress, asteniya i kognitivnye rasstroistva. S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(5):23-29. (In Russ.). https://doi.org/10.17116/jnevro202212205123
  36. Garner R, Baraniuk JN. Orthostatic intolerance in chronic fatigue syndrome. J Transl Med. 2019;17(1):185.  https://doi.org/10.1186/s12967-019-1935-y
  37. Natelson BH, Lin JS, Blate M, et al. Physiological assessment of orthostatic intolerance in chronic fatigue syndrome. J Transl Med. 2022;20(1):95.  https://doi.org/10.1186/s12967-022-03289-8
  38. Ocon AJ. Caught in the thickness of brain fog: exploring the cognitive symptoms of Chronic Fatigue Syndrome. Front Physiol. 2013;4:63.  https://doi.org/10.3389/fphys.2013.00063
  39. Cvejic E, Birch RC, Vollmer-Conna U. Cognitive Dysfunction in Chronic Fatigue Syndrome: a Review of Recent Evidence. Curr Rheumatol Rep. 2016;18(5):24.  https://doi.org/10.1007/s11926-016-0577-9
  40. Robinson LJ, Gallagher P, Watson S, et al. Impairments in cognitive performance in chronic fatigue syndrome are common, not related to co-morbid depression but do associate with autonomic dysfunction. PLoS One. 2019;14(2):e0210394. https://doi.org/10.1371/journal.pone.0210394
  41. Capuron L, Welberg L, Heim C. Cognitive Dysfunction Relates to Subjective Report of Mental Fatigue in Patients with Chronic Fatigue Syndrome. Neuropsychopharmacol. 2006;31:1777-1784. https://doi.org/10.1038/sj.npp.1301005
  42. Aoun Sebaiti M, Hainselin M, Gounden Y. Systematic review and meta-analysis of cognitive impairment in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Sci Rep. 2022;12:2157  https://doi.org/10.1038/s41598-021-04764-w
  43. Morris G, Maes M, Berk M, Puri BK. Myalgic encephalomyelitis or chronic fatigue syndrome: how could the illness develop? Metabolic Brain Disease. 2019;34(2):385-415.  https://doi.org/10.1007/s11011-019-0388-6
  44. Santamarina-Perez P, Eiroa-Orosa FJ, Freniche V, et al. Length of illness does not predict cognitive dysfunction in chronic fatigue syndrome. Appl Neuropsychol. 2011;18(3):216-222.  https://doi.org/10.1080/09084282.2011.595448
  45. Lokshina AB, Zakharov VV. Dvuedinstvo astenii i kognitivnykh rasstroistv pri tserebral’nykh zabolevaniyakh. Meditsinskii sovet. 2023;17(21):20-27. (In Russ.). https://doi.org/10.21518/ms2023-401
  46. Heneka MT, Golenbock D, Latz E, et al. Immediate and longterm consequences of COVID-19 infections for the development of neurological disease. Alzheimers Res Ther. 2020;12(1):69.  https://doi.org/10.1186/s13195-020-00640-3
  47. Smith BJ, Lim MH. How the COVID-19 pandemic is focusing attention on loneliness and social isolation. Public Health Res Pract. 2020;30(2):3022008. https://doi.org/10.17061/phrp3022008
  48. Alemanno F, Houdayer E, Parma A, et al. COVID-19 cognitive deficits after respiratory assistance in the subacute phase: A COVID-rehabilitation unit experience. PLoS ONE. 2021;16(2):e0246590. https://doi.org/10.1371/journal.pone.0246590
  49. Davis HE, Assaf GS, McCorkell L, et al. Characterizing long COVID in an international cohort: 7 months of symptoms and their impact. eClinicalMedicine. 2021;38:101019. https://doi.org/10.1016/j.eclinm.2021.101019
  50. Che X, Brydges CR, YuY. Evidence for Peroxisomal Dysfunction and Dysregulation of the CDP-Choline Pathway in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. Preprint. medRxiv. 2022;2021.06.14.21258895. https://doi.org/10.1101/2021.06.14.21258895
  51. Secades JJ. Citicoline: pharmacological and clinical review. Rev Neurol. 2016;63(03):1-73. 
  52. Mashin VV, Belova LA, Bakhtogarimov IR. Multicenter observational program for evaluating the effectiveness of the drug rekogan (citicoline) in the correction of cognitive impairment in patients with chronic cerebrovascular pathology. S.S. Korsakov Journal of Neurology and Psychiatry. 2017;117(8):39-43. (In Russ.). https://doi.org/10.17116/jnevro20171178139-43
  53. Belova LA, Mashin VV, Dudikov EM, et al. The multicenter observational program to assess the effectiveness of complex therapy preparations Cortexin and recogne (citicoline) cognitive impairment in patients with chronic cerebrovascular disease. S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(2):35-38. (In Russ.). https://doi.org/10.17116/jnevro201911902135
  54. Putilina MV. Personifitsirovannyi vybor preparatov — predshestvennikov kholina s pozitsii dokazatel’noi meditsiny. S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(6):144-151. (In Russ.). https://doi.org/10.17116/jnevro2020120061144
  55. Marston KJ, Brown BM, Rainey-Smith SR, Peiffer JJ. Resistance Exercise-Induced Responses in Physiological Factors Linked with Cognitive Health. J Alzheimers Dis. 2019;68(1):39-64.  https://doi.org/10.3233/JAD-181079
  56. Gareri P, Castagna A, Cotroneo AM, et al. The role of citicoline in cognitive impairment: pharmacological characteristics, possible advantages, and doubts for an old drug with new perspectives. Clin Interv Aging. 2015;10:1421-1429. https://doi.org/10.2147/cia.s87886
  57. Nemkova SA, Semenov DV, Zavadenko NN, Vozvyshaeva MYu. Vliyanie primeneniya preparata Rekognan (tsitikolin) na proyavleniya pozitivnykh lichnostnykh kachestv u patsientov s astenicheskim sindromom i legkimi kognitivnymi narusheniyami. S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(1):44-50. (In Russ.). https://doi.org/10.17116/jnevro202012001144
  58. Nemkova SA, Semenov DV, Petrova EA, et al. Vliyanie preparata Rekognan na sostoyanie vysshikh psikhicheskikh funktsii u patsientov s legkimi kognitivnymi narusheniyami. S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(9):51-57. (In Russ.). https://doi.org/10.17116/jnevro202112109151
  59. Chutko LS, Surushkina SYu, Iakovenko EA, et al. Impairments of cognitive control in patients with somatoform disorders and their treatment. S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(4):32-37. (In Russ.). https://doi.org/10.17116/jnevro201911904132

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