Spectral analysis in metabolomics of skin neoplasms

Timurzieva A.B.; Zudin A.B.

doi:https://doi.org/10.17116/klinderma202524031277

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INTRODUCTION

Malignant skin neoplasms are widespread in general population. Differentiation of skin tumors in express mode is one of the important tasks in doctor’s practice. Raman scattering spectroscopy deserves special attention in this aspect.

OBJECTIVE

To justify the use of spectral analysis in correlation with the molecular composition and pathogenetic features of skin neoplasms compared to the data of the non-damaged tissue.

MATERIAL AND METHODS

Analysis of domestic and foreign literature sources in such databases as PubMed, eLIBRARY, ResearchGate, Elsevier, Scopus, Web of Science, regarding some pathogenic mechanisms of tumor formation in correlation with their molecular composition was carried out. The feasibility of performing spectral analysis of tissues using the effect of Raman scattering spectroscopy in skin neoplasms is substantiated.

RESULTS

The value of Raman scattering spectroscopy has been demonstrated during the analysis in the perspective of determining biomarkers of the tumor process. Some pathogenetic molecular features of skin tissue in the normal condition and in skin neoplasms and the perspective of their interpretation by the method of Raman scattering spectroscopy have been analyzed.

CONCLUSION

The obtained data can be used to develop a differential diagnostic algorithm that allows to distinguish benign and malignant skin neoplasms based on their metabolomic markers and spectral characteristics. Each spectral criterion in correlation with the pathogenetic mechanisms of tumor formation will allow to perform optical diagnostics in express mode in the future.

Keywords:

metabolomics

skin neoplasms

Raman scattering spectroscopy

biomarkers

early diagnosis of cancer

spectral analysis

Authors:

Timurzieva A.B.

N.A. Semashko National Research Institute of Public Health

ORCID: 0000-0003-1817-3228

Zudin A.B.

Semashko National Research Institute of Public Health

ORCID: 0000-0002-6966-5559

Received:

22.10.2024

Accepted:

21.03.2025

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References:

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