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Gorbachev N.A.

Sechenov First Moscow State Medical University (Sechenov University)

Balabanova M.A.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Zakharova A.S.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Poluektov M.G.

Sechenov First Moscow State Medical University (Sechenov University)

Current issues of diagnosis and therapy of patients with restless legs syndrome

Authors:

Gorbachev N.A., Balabanova M.A., Zakharova A.S., Poluektov M.G.

More about the authors

Read: 590 times


To cite this article:

Gorbachev NA, Balabanova MA, Zakharova AS, Poluektov MG. Current issues of diagnosis and therapy of patients with restless legs syndrome. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;124(10):7‑11. (In Russ.)
https://doi.org/10.17116/jnevro20251251017

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References:

  1. Silber MH, Buchfuhrer MJ, Early CJ, et al. The Management of Restless Legs Syndrome: An Updated Algorithm. Mayo Clinic Proceedings. 2021;96(7):1921-1937. https://doi.org/10.1016/j.mayocp.2020.12.026
  2. Winkelman JW, Berkowski JA, DelRosso LM, et al. Treatment of restless legs syndrome and periodic limb movement disorder: an American Academy of Sleep Medicine clinical practice guideline. Journal of Clinical Sleep Medicine. 2025;21(1):137-152.  https://doi.org/10.5664/jcsm.11390
  3. Allen RP, Picchietti DL, Garcia-Borreguero D, et al. Restless legs syndrome/Willis-Ekbom disease diagnostic criteria: Updated International Restless Legs Syndrome Study Group (IRLSSG) consensus criteria — history, rationale, description, and significance. Sleep Medicine. 2014;15(8):860-873.  https://doi.org/10.1016/j.sleep.2014.03.025
  4. Akhmadulina AO, Chimagomedova ASh, Levin OS, Poluektov MG. Clinical phenomenology and pathophysiology of daytime and nighttime imperative movements. S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(11-2):67-72. (In Russ.). https://doi.org/10.17116/jnevro202212211267
  5. Schormair B, Zhao C, Bell S, et al. Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry: a meta-analysis. Lancet Neurology. 2017;16(11):898-907.  https://doi.org/10.1016/S1474-4422(17)30327-7
  6. Jimenez-Jimenez FJ, Alonso-Navarro H, Garcia-Martin E, et al. Genetics of restless legs syndrome: An update. Sleep Medicine Reviews. 2017;39:108-121.  https://doi.org/10.1016/j.smrv.2017.08.002
  7. Gonzalez-Latapi P, Malkani R. Update on Restless Legs Syndrome: from Mechanisms to Treatment. Current Neurology and Neuroscience Reports. 2019;19(8):1-12.  https://doi.org/10.1007/s11910-019-0965-4
  8. Trenkwalder C, Allen R, Hogl B, et al. Comorbidities, treatment, and pathophysiology in restless legs syndrome. The Lancet Neurology. 2018;17(11):994-1005. https://doi.org/10.1016/S1474-4422(18)30311-9
  9. Sowers JR, Vlachakis N. Circadian variation in plasma dopamine levels in man. Journal of Endocrinological Investigation: Official Journal of the Italian Society of Endocrinology. 1984;7(4):341-345.  https://doi.org/10.1007/BF03351014
  10. Li Y, Zhao Z, Tan Y-y, Wang X. Dynamical analysis of the effects of circadian clock on the neurotransmitter dopamine. MathematicalBioscience and Engineering. 2023;20(9):16663-16677. https://doi.org/10.3934/mbe.2023742
  11. Skagerberg G, Bjorklund A, Lindwall O, Schmidt RH. Origin and termination of the diencephalo-spinal dopamine system in the rat. Brain Research Bulletin. 1982;9(1-6):237-244.  https://doi.org/10.1016/0361-9230(82)90136-8
  12. Trenkwalder C, Allen R, Hogl B, et al. Restless legs syndrome associated with major diseases. Neurology. 2016;86(14):1336-1343. https://doi.org/10.1212/WNL.0000000000002542
  13. Byrne R, Sinha S, Chaudhuri KR. Restless legs syndrome: Diagnosis and review of management options. Neuropsychiatric Disorders and Treatment. 2006;2(2):155-164.  https://doi.org/10.2147/nedt.2006.2.2.155
  14. Picchietti D, Allen RP, Walters AS. Restless Legs Syndrome: Prevalence and Impact in Children and Adolescents—The Peds REST Study. Pediatrics. 2007;120(2):253-266.  https://doi.org/10.1542/peds.2006-2767
  15. Trotti LM, Becker LA. Iron for the treatment of restless legs syndrome. Cochrane Database of Systematic Reviews. 2019;2019(1):1-45.  https://doi.org/10.1002/14651858.CD007834.pub3
  16. Gossard TR, Trotti LM, Videnovic EK, et al. Restless Legs Syndrome: Contemporary Diagnosis and Treatment. Neurotherapeutics. 2021;18(1):140-155.  https://doi.org/10.1007/s13311-021-01019-4
  17. Allen, RP. Defining the phenotype of the restless legs syndrome (RLS) using age-of-symptom-onset. Sleep Medicine. 2000;1(1):11-19.  https://doi.org/10.1016/s1389-9457(99)00012-x
  18. Figorilli M, Puligheddu M, Ferri R. Restless Legs Syndrome/Willis-Ekbom Disease and Periodic Limb Movements in Sleep in the Elderly with and without Dementia. Sleep Medicine Clinics. 2015;10(3):331-342.  https://doi.org/10.1016/j.jsmc.2015.05.011
  19. Garcia-Borreguero D, Silber MH, Winkelman JW, et al. Guidelines for the first-line treatment of restless legs syndrome/Willis-Ekbom disease, prevention and treatment of dopaminergic augmentation: A combined task force of the IRLSSG, EURLSSG, and the RLS-foundation. Sleep Medicine. 2016;21:1-11.  https://doi.org/10.1016/j.sleep.2016.01.017
  20. Garcia-Borreguero D, Allen RP, Kohnen R, et al; International Restless Legs Syndrome Study Group (IRLSSG). Diagnostic Standards for Dopaminergic Augmentation of Restless Legs Syndrome: Report from a World Association of Sleep Medicine — International Restless Legs Syndrome Study Group Consensus Conference at the Max Planck Institute. Sleep Medicine. 2007;8(5):520-530.  https://doi.org/10.1016/j.sleep.2007.03.022
  21. Gorbachev NA, Poluektov MG. Augmentation of Restless Legs Syndrome. Effektivnaya farmakoterapiya. 2024;20(14):30-37. (In Russ.).
  22. Gorbachev NA, Obukhova AV, Fedeneva LA, Poluektov MG. Clinical and neurophysiological features of the augmentation phenomenon in restless legs syndrome. Nevrologiya, nejropsihiatriya, psihosomatika. 2024;16(3):19-25. (In Russ.). https://doi.org/10.14412/2074-2711-2024-3-19-25
  23. Garcia-Borreguero D, Kohnen R, Silber MH, et al. The long-term treatment of restless legs syndrome/Willis-Ekbom disease: Evidence-based guidelines and clinical consensus best practice guidance: A report from the International Restless Legs Syndrome Study Group. Sleep Medicine. 2013;14(7):675-684.  https://doi.org/10.1016/j.sleep.2013.05.016
  24. Comella CL. Treatment of Restless Legs Syndrome. Neurotherapeutics. 2014;11(1):177-187.  https://doi.org/10.1007/s13311-013-0247-9
  25. Trenkwalder C, Paulus W. Pharmacological treatments of augmentation in restless legs syndrome patients. Advances in Pharmacology. — 2019;84:255-265.  https://doi.org/10.1016/bs.apha.2019.02.002
  26. Garcia-Borreguero D, Garcia-Malo C, Granzio JJ, et al. A Randomized, Placebo-Controlled Crossover Study with Dipyridamole for Restless Legs Syndrome. Movement Disorders. 2021;36(10):2387-2392. https://doi.org/10.1002/mds.28668
  27. Trenkwalder C, Benes H, Grote L, et al; RELOXYN Study Group. Prolonged release oxycodone-naloxone for treatment of severe restless legs syndrome after failure of previous treatment: A double-blind, randomised, placebo-controlled trial with an open-label extension. Lancet Neurology. 2013;12(12):1141-1150. https://doi.org/10.1016/S1474-4422(13)70239-4
  28. Harrison EG, Keating JL, Morgan PE. Non-pharmacological interventions for restless legs syndrome: a systematic review of randomised controlled trials. Disability and Rehabilitation.2019;41(17):2006-2014. https://doi.org/10.1080/09638288.2018.1453875
  29. Lettieri CJ, Eliasson AH. Pneumatic compression devices are an effective therapy for restless legs syndrome: A prospective, randomized, double-blinded, sham-controlled trial. Chest. 2009;135(1):74-80.  https://doi.org/10.1378/chest.08-1665
  30. Gorbachev NA, Obukhova AV, Poluektov MG. Efficacy of transvertebral electrical stimulation and pneumatic compression in restless legs syndrome and augmentation phenomenon. Farmakologiya & Farmakoterapiya. 2024;2: 78-82. (In Russ.). https://doi.org/10.46393/27132129_2024_2_78
  31. Heide AC, Winkler T, Helms HJ, et al. Effects of transcutaneous spinal direct current stimulation in idiopathic restless legs patients. Brain Stimulation. 2014;7(5):636-642.  https://doi.org/10.1016/j.brs.2014.06.008

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