The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.
Gafarov V.V.
Research Institute of Therapy and Preventive Medicine — branch of the Institute of Cytology and Genetics Siberian Branch of the Russian Academy of Sciences;
Collaborative Laboratory of Epidemiology of Cardiovascular Diseases
Gromova E.A.
Research Institute of Therapy and Preventive Medicine — branch of the Institute of Cytology and Genetics Siberian Branch of the Russian Academy of Sciences;
Collaborative Laboratory of Epidemiology of Cardiovascular Diseases
Gubina M.A.
Institute of Cytology and Genetics Siberian Branch of the Russian Academy of Sciences
Gagulin I.V.
Research Institute of Therapy and Preventive Medicine — branch of the Institute of Cytology and Genetics Siberian Branch of the Russian Academy of Sciences;
Collaborative Laboratory of Epidemiology of Cardiovascular Diseases
Maksimov V.N.
Research Institute of Therapy and Preventive Medicine — branch of the Institute of Cytology and Genetics Siberian Branch of the Russian Academy of Sciences
Gafarova A.V.
Research Institute of Therapy and Preventive Medicine — branch of the Institute of Cytology and Genetics Siberian Branch of the Russian Academy of Sciences;
Collaborative Laboratory of Epidemiology of Cardiovascular Diseases
The association of polymorphisms of the serotonin transporter gene SLC6A4 with depression
Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(2): 135‑139
Views: 797
Downloaded: 3
To cite this article:
Gafarov VV, Gromova EA, Gubina MA, Gagulin IV, Maksimov VN, Gafarova AV. The association of polymorphisms of the serotonin transporter gene SLC6A4 with depression. S.S. Korsakov Journal of Neurology and Psychiatry.
2024;124(2):135‑139. (In Russ.)
https://doi.org/10.17116/jnevro2024124021135
To study the relationship of polymorphic variants of the SLC6A4 gene with depression among people aged 25—44 years in Novosibirsk.
Under the WHO program «MONICA-psychosocial (MOPSY)», a random representative sample of people aged 25—44 years from the population of the Oktyabrsky district of Novosibirsk (men n=725, mean age 43.4±0.4 years, response — 71.3%, women n=710, mean age 44.8±0.4 years, response — 72%). Depression was assessed using the MONICA-MOPSY psychosocial questionnaire. Every fourth respondent was examined for polymorphic variants of 5HTTLPR-VNTR SNP rs25531 A>G of the SLC6A4 gene. The study was carried out within the framework of the budget topic Reg. No. 122031700094-5.
The high level of depression among people aged 25—44 was 12.8% (for men 9.1%, for women — 15.92%); the average level of depression occurred in 24.5% of the population (among men in 21.24%, among women in 26.76%) (χ2=17.071, df=2, p<0.001). The most common genotype of the SLC6A4 gene, among people aged 25-—4 years old in Novosibirsk, was SLA — 43.29%, LALA — 26.53% — in second place, SS — 17.87% — third, LALG — 6 genotypes were less represented genotypes. 74%, SLG — 4.18%, LGLG — 1.39%. Carrying the SLA genotype (53.3% and 63.6%) increased the chance of developing both the average level of depression by 2.359 (95% CI 1.278—4.355) times, and depression in general by 1.933 (95% CI 1.142—3.271) times, compared with persons carrying the LALA genotype (32.0% and 46.9%), (χ2=7.674, df=1, p<0.01 and χ2=6.095, df=1, p<0.05). Persons carrying the LALG genotype (54.5%) also had a higher chance of developing a mean level of depression RR=2.929 (95% CI 1.039—8.261), compared with carriers of the LALA genotype (32.0%) (χ2=4.326, df =1, p<0.05) (p<0.05).
Associative links between polymorphic variants of the SLC6A4 gene and depression have been established.
Keywords:
Authors:
Gafarov V.V.
Research Institute of Therapy and Preventive Medicine — branch of the Institute of Cytology and Genetics Siberian Branch of the Russian Academy of Sciences;
Collaborative Laboratory of Epidemiology of Cardiovascular Diseases
Gromova E.A.
Research Institute of Therapy and Preventive Medicine — branch of the Institute of Cytology and Genetics Siberian Branch of the Russian Academy of Sciences;
Collaborative Laboratory of Epidemiology of Cardiovascular Diseases
Gubina M.A.
Institute of Cytology and Genetics Siberian Branch of the Russian Academy of Sciences
Gagulin I.V.
Research Institute of Therapy and Preventive Medicine — branch of the Institute of Cytology and Genetics Siberian Branch of the Russian Academy of Sciences;
Collaborative Laboratory of Epidemiology of Cardiovascular Diseases
Maksimov V.N.
Research Institute of Therapy and Preventive Medicine — branch of the Institute of Cytology and Genetics Siberian Branch of the Russian Academy of Sciences
Gafarova A.V.
Research Institute of Therapy and Preventive Medicine — branch of the Institute of Cytology and Genetics Siberian Branch of the Russian Academy of Sciences;
Collaborative Laboratory of Epidemiology of Cardiovascular Diseases
Received:
31.03.2023
Accepted:
07.11.2023
List of references:
Close metadata
Email Confirmation
An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.
Email Confirmation
Log in to the site using your account in one of the services
We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.