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Gafarov V.V.

Research Institute of Therapy and Preventive Medicine — branch of the Institute of Cytology and Genetics Siberian Branch of the Russian Academy of Sciences;
Collaborative Laboratory of Epidemiology of Cardiovascular Diseases

Gromova E.A.

Research Institute of Therapy and Preventive Medicine — branch of the Institute of Cytology and Genetics Siberian Branch of the Russian Academy of Sciences;
Collaborative Laboratory of Epidemiology of Cardiovascular Diseases

Gubina M.A.

Institute of Cytology and Genetics Siberian Branch of the Russian Academy of Sciences

Gagulin I.V.

Research Institute of Therapy and Preventive Medicine — branch of the Institute of Cytology and Genetics Siberian Branch of the Russian Academy of Sciences;
Collaborative Laboratory of Epidemiology of Cardiovascular Diseases

Maksimov V.N.

Research Institute of Therapy and Preventive Medicine — branch of the Institute of Cytology and Genetics Siberian Branch of the Russian Academy of Sciences

Gafarova A.V.

Research Institute of Therapy and Preventive Medicine — branch of the Institute of Cytology and Genetics Siberian Branch of the Russian Academy of Sciences;
Collaborative Laboratory of Epidemiology of Cardiovascular Diseases

The association of polymorphisms of the serotonin transporter gene SLC6A4 with depression

Authors:

Gafarov V.V., Gromova E.A., Gubina M.A., Gagulin I.V., Maksimov V.N., Gafarova A.V.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(2): 135‑139

DOI: 10.17116/jnevro2024124021135

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Table of contents

THE ASSOCIATION OF POLYMORPHISMS OF THE SEROTONIN TRANSPORTER GENE SLC6A4 WITH DEPRESSION
THE ASSOCIATION OF POLYMORPHISMS OF THE SEROTONIN TRANSPORTER GENE SLC6A4 WITH DEPRESSION

To cite this article:

Gafarov VV, Gromova EA, Gubina MA, Gagulin IV, Maksimov VN, Gafarova AV. The association of polymorphisms of the serotonin transporter gene SLC6A4 with depression. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(2):135‑139. (In Russ.)
https://doi.org/10.17116/jnevro2024124021135

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
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Abstract:

OBJECTIVE

To study the relationship of polymorphic variants of the SLC6A4 gene with depression among people aged 25—44 years in Novosibirsk.

MATERIAL AND METHODS

Under the WHO program «MONICA-psychosocial (MOPSY)», a random representative sample of people aged 25—44 years from the population of the Oktyabrsky district of Novosibirsk (men n=725, mean age 43.4±0.4 years, response — 71.3%, women n=710, mean age 44.8±0.4 years, response — 72%). Depression was assessed using the MONICA-MOPSY psychosocial questionnaire. Every fourth respondent was examined for polymorphic variants of 5HTTLPR-VNTR SNP rs25531 A>G of the SLC6A4 gene. The study was carried out within the framework of the budget topic Reg. No. 122031700094-5.

RESULTS

The high level of depression among people aged 25—44 was 12.8% (for men 9.1%, for women — 15.92%); the average level of depression occurred in 24.5% of the population (among men in 21.24%, among women in 26.76%) (χ2=17.071, df=2, p<0.001). The most common genotype of the SLC6A4 gene, among people aged 25-—4 years old in Novosibirsk, was SLA — 43.29%, LALA — 26.53% — in second place, SS — 17.87% — third, LALG — 6 genotypes were less represented genotypes. 74%, SLG — 4.18%, LGLG — 1.39%. Carrying the SLA genotype (53.3% and 63.6%) increased the chance of developing both the average level of depression by 2.359 (95% CI 1.278—4.355) times, and depression in general by 1.933 (95% CI 1.142—3.271) times, compared with persons carrying the LALA genotype (32.0% and 46.9%), (χ2=7.674, df=1, p<0.01 and χ2=6.095, df=1, p<0.05). Persons carrying the LALG genotype (54.5%) also had a higher chance of developing a mean level of depression RR=2.929 (95% CI 1.039—8.261), compared with carriers of the LALA genotype (32.0%) (χ2=4.326, df =1, p<0.05) (p<0.05).

CONCLUSION

Associative links between polymorphic variants of the SLC6A4 gene and depression have been established.

Keywords:

SLC6A4 gene
depression
persons aged 25-44

Authors:

Gafarov V.V.

Research Institute of Therapy and Preventive Medicine — branch of the Institute of Cytology and Genetics Siberian Branch of the Russian Academy of Sciences;
Collaborative Laboratory of Epidemiology of Cardiovascular Diseases

Gromova E.A.

Research Institute of Therapy and Preventive Medicine — branch of the Institute of Cytology and Genetics Siberian Branch of the Russian Academy of Sciences;
Collaborative Laboratory of Epidemiology of Cardiovascular Diseases

Gubina M.A.

Institute of Cytology and Genetics Siberian Branch of the Russian Academy of Sciences

Gagulin I.V.

Research Institute of Therapy and Preventive Medicine — branch of the Institute of Cytology and Genetics Siberian Branch of the Russian Academy of Sciences;
Collaborative Laboratory of Epidemiology of Cardiovascular Diseases

Maksimov V.N.

Research Institute of Therapy and Preventive Medicine — branch of the Institute of Cytology and Genetics Siberian Branch of the Russian Academy of Sciences

Gafarova A.V.

Research Institute of Therapy and Preventive Medicine — branch of the Institute of Cytology and Genetics Siberian Branch of the Russian Academy of Sciences;
Collaborative Laboratory of Epidemiology of Cardiovascular Diseases

Received:

31.03.2023

Accepted:

07.11.2023

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