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Zhuravleva M.V.

I.M. Sechenov First Moscow State Medical University (Sechenov University);
Scientific Centre for Expert Evaluation of Medicinal Products

Luchinina E.V.

V.I. Razumovsky Saratov State Medical University

Gorbachev N.A.

Sechenov First Moscow State Medical University (Sechenov University)

Poluektov M.G.

Sechenov First Moscow State Medical University (Sechenov University)

The use of zolpidem in the treatment of acute and chronic insomnia

Authors:

Zhuravleva M.V., Luchinina E.V., Gorbachev N.A., Poluektov M.G.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2025;125(5‑2): 52‑56

DOI: 10.17116/jnevro202512505252

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Table of contents

THE USE OF ZOLPIDEM IN THE TREATMENT OF ACUTE AND CHRONIC INSOMNIA
THE USE OF ZOLPIDEM IN THE TREATMENT OF ACUTE AND CHRONIC INSOMNIA

To cite this article:

Zhuravleva MV, Luchinina EV, Gorbachev NA, Poluektov MG. The use of zolpidem in the treatment of acute and chronic insomnia. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;125(5‑2):52‑56. (In Russ.)
https://doi.org/10.17116/jnevro202512505252

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))
 
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Abstract:

The pharmacological features and practice of using the benzodiazepine receptor agonist zolpidem are analyzed. The issues of definition and clinical significance of insomnia in medical practice and the grounds for choosing a class of hypnotic drugs for its treatment are discussed. The main pharmacokinetic and pharmacodynamic properties of zolpidem are described. The data of studies on its effect on subjective and objective sleep parameters, safety and side effects, features of administration to different groups of patients and long-term use (up to 12 months) are presented.

Keywords:

zolpidem
insomnia
hypnotics
sleep disorder’s therapy

Authors:

Zhuravleva M.V.

I.M. Sechenov First Moscow State Medical University (Sechenov University);
Scientific Centre for Expert Evaluation of Medicinal Products

Luchinina E.V.

V.I. Razumovsky Saratov State Medical University

Gorbachev N.A.

Sechenov First Moscow State Medical University (Sechenov University)

Poluektov M.G.

Sechenov First Moscow State Medical University (Sechenov University)

Received:

18.03.2025

Accepted:

19.03.2025

Close metadata

References:

  1. The AASM International Classification of Sleep Disorders. Third Edition, Text Revision (ICSD-3-TR). Accessed March 6,2025. https://aasm.org/clinical-resources/international-classification-sleep-disorders/
  2. Poluektov MG. Diagnostika i lechenie rasstrojstv sna. M.: MEDpress-inform. 2016;256. (In Russ.). ISBN 978-5-00030-300-9. 
  3. Roth T. Insomnia: Definition, prevalence, etiology and consequences. J Clin Sleep Med. 2007;(3 suppl 5):7-10.  https://doi.org/10.5664/jcsm.26929
  4. Morphy H, Dunn KM, Lewis M, et al. Epidemiology of insomnia: a longitudinal study in a UK population. Sleep. 2007;30:274-280.  https://doi.org/10.1093/sleep/30.3.274
  5. Spielman A, Caruso L, Glovinsky P. A behavioral perspective on insomnia treatment. Psychiatr Clin North Am. 1987;(10):541-553.  https://doi.org/10.1016/S0193-953X(18)30532-X
  6. Morin CM, Belanger L, LeBlanc M, et al. The natural history of insomnia: a population-based 3-year longitudinal study. Arch Int Med. 2009;169:447-453.  https://doi.org/10.1001/archinternmed.2008.610
  7. Buysse DJ. Chronic insomnia. Am J Psychiatry. 2008;165:678-686.  https://doi.org/10.1176/appi.ajp.2008.08010129
  8. Winkelman JW, Buxton OM, Jensen JE, et al. Reduced brain GABA in primary insomnia: preliminary data from 4T proton magnetic resonance spectroscopy (1H-MRS). Sleep. 2008;31(11):1499-1506. https://doi.org/10.1093/sleep/31.11.1499
  9. Morgan PT, Pace-Schott EF, Mason GF, et al. Cortical GABA levels in primary insomnia. Sleep. 2012;35:807-814.  https://doi.org/10.5665/sleep.1880
  10. Crescenzo F, D’Alò GL, Ostinelli EG, et al. Comparative effects of pharmacological interventions for the acute and long-term management of insomnia disorder in adults: a systematic review and network meta-analysis. Lancet. 2022;400:170-184.  https://doi.org/10.1016/s0140-6736(22)00878-9
  11. Kartashov VA, Chepurnaya GP, Chernova LV. Definition of zaleplon, zolpidem and zopiclon in biological objects. Drug Development & Registration. 2018;(1):206-214. (In Russ.).
  12. Borisova EO. Zolpidem is a modern effective drug for the treatment of insomnia. Pharmateka. 2001;(3):23-27. (In Russ.).
  13. Register of Medicines of Russia. Zolpidem. Available on 06.03.25. (In Russ.). https://www.rlsnet.ru/active-substance/zolpidem-2053
  14. Guinebault P, Dubruc C, Hermann P, et al. High-performance liquid chromatographic determination of zolpidem, a new sleep inducer, in biological fluids with fluorimetric detection. J Chromatogr. 1986;383(1):206-211. 
  15. Von Moltke LL, Greenblatt DJ, Granda BW, et al. Zolpidem metabolism in vitro: responsible cytochromes, chemical inhibitors, and in vivo correlations. Br J Clin Pharmacol. 1999;48(1):89-97.  https://doi.org/10.1046/j.1365-2125.1999.00953.x
  16. Pichard L, Gillet G, Bonfils C, et al. Oxidative metabolism of zolpidem by human liver cytochrome P450S. Drug Metabol Dispos. 1995;23(11):1253-1262. https://doi.org/10.1016/s0090-9556(25)06824-2
  17. Hempel G, Blaschke G. Direct determination of zolpidem and its main metabolites in urine using capillary electrophoresis with laser-induced fluorescence detection. J Chromatography. 1996;675(1):131-137.  https://doi.org/10.1016/0378-4347(95)00342-8
  18. State register of medicines. Rifampicin. Available on 06.03.25. (In Russ.). https://grls.rosminzdrav.ru/Grls_View_v2.aspx?routingGuid=8f5760f2-825e-4363-bdc9-b28cdddee2e3
  19. Terzano MG, Rossi M, Palomba V, et al. New drugs for insomnia: comparative tolerability of zopiclone, zolpidem and zaleplon. Drug Safety. 2003;26(4):261-282.  https://doi.org/10.2165/00002018-200326040-00004
  20. Dockhorn RJ, Dockhorn DW. Zolpidem in the treatment of short-term insomnia: a randomized, double-blind, placebo controlled clinical trial. Clin Neuropharmacol. 1996;19:333-340.  https://doi.org/10.1097/00002826-199619040-00006
  21. Walsh JK, Erman M, Erwin CW, et al. Subjective hypnotic efficacy of trazodone and zolpidem in DSMIII-R primary insomnia. Human Psychopharmacol. 1998;13:191-198.  https://doi.org/10.1002/(SICI)1099-1077(199804)13:3<191::AID-HUP972>3.0.CO;2-X
  22. Levin YI. Insomnia: clinical experience with zolpidem (sanval). Neurology, Neuropsychiatry, Psychosomatics. 2010;3:87-91. (In Russ.). https://doi.org/10.14412/2074-2711-2010-108
  23. MacFarlane J, Morin CM, Montplaisir J. Hypnotics in Insomnia: The Experience of Zolpidem. Clin Ther. 2014;36(11):1676-1701. https://doi.org/10.1016/j.clinthera.2014.09.017
  24. Krystal AD, Erman M, Zammit GK, et al; ZOLONG Study Group. Long-term efficacy and safety of zolpidem extended-release 12.5 mg, administered 3 to 7 nights per weekfor24weeks, in patients with chronic primary insomnia: a 6 month, randomized, double-blind, placebo-controlled, parallel-group, multicenter study. Sleep. 2008;31:79-90.  https://doi.org/10.1093/sleep/31.1.79
  25. Roth T, Soubrane C, Titeux L, et al. Efficacy and safety of zolpidem-MR: a double-blind, placebo-controlled study in adults with primary insomnia. Sleep Med. 2006;7:397-406.  https://doi.org/10.1016/j.sleep.2006.04.008
  26. Randall S, Roehrs TA, Roth T. Efficacy of eight months of nightly zolpidem: a prospective placebo-controlled study. Sleep. 2012;35:1551-1557. https://doi.org/10.5665/sleep.2208
  27. Scharf MB, Roth T, Vogel GW, et al. A multicenter, placebo-controlled study evaluating zolpidem in the treatment of chronic insomnia. J Clin Psychiatr. 1994;55:192-199. 
  28. Roger M, Attali P, Coquelin JP. Multicenter, double-blind, controlled comparison of zolpidem and triazolam in elderly patients with insomnia. Clin Ther. 1993;15:127-136. 
  29. Leppik IE, Roth-Schechter GB, Gray GW, et al. Double-blind, placebo-controlled comparison of zolpidem, triazolam, and temazepam in elderly patients with insomnia. Drug Dev Res. 1997;40:230-238.  https://doi.org/10.1002/(SICI)1098-2299(199703)40:3<230::AID-DDR3>3.0.CO;2-L
  30. Monti JM, Attali P, Monti D, et al. Zolpidem and rebound insomnia —a double-blind, controlled polysomnographic study in chronic insomniac patients. Pharmacopsychiatry. 1994;27:166-175.  https://doi.org/10.1055/s-2007-1014298
  31. Silvestri R, Ferrillo F, Murri L, et al. Rebound insomnia after abrupt discontinuation of hypnotic treatment: double-blind randomized comparison of zolpidem versus triazolam. Human Psychopharmacol. 1996;11:225-233.  https://doi.org/10.1002/(SICI)1099-1077(199605)11:3<225::AID-HUP791>3.0.CO;2-2
  32. Dolder CR, Nelson MH. Hypnosedative-induced complex behaviours: incidence, mechanisms and management. CNS Drugs. 2008;22:1021-1036. https://doi.org/10.2165/0023210-200822120-00005
  33. Hoque R, Chesson AL Jr. Zolpidem-induced sleepwalking, sleep related eating disorder, and sleep-driving: fluorine-18 flourodeoxyglucose positron emission tomography analysis, and a literature review of other unexpected clinical effects of zolpidem. J Clin Sleep Med. 2009;5:471-476.  https://doi.org/10.5664/jcsm.27605
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