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Yakupov E.Z.

LLC «Scientific research Medical Complex «Your Health»

Burd S.G.

Pirogov Russian National Research Medical University (Pirogovsky University);
Federal Center of Brain and Neurotechnologies

Barantsevich E.R.

Academian I.P. Pavlov First Saint Petersburg State Medical University

Gamieva R.A.

LLC «Scientific research Medical Complex «Your Health»

Mendel O.I.

LLC «Unipharm»

Lebedeva A.V.

Pirogov Russian National Research Medical University (Pirogovsky University);
Federal Center of Brain and Neurotechnologies

Rubleva Y.V.

Federal Center of Brain and Neurotechnologies

Pantina N.V.

Federal Center of Brain and Neurotechnologies

Bokitko T.A.

Federal Center of Brain and Neurotechnologies

Kovaleva I.I.

Federal Center of Brain and Neurotechnologies

Bogomazova M.A.

Federal Center of Brain and Neurotechnologies

Efimenko A.P.

Federal Center of Brain and Neurotechnologies

Smochilin A.G.

Academian I.P. Pavlov First Saint Petersburg State Medical University

The results of a multicenter open observational study of the efficacy and safety of the dietary supplement Neururidine N in patients with acute nonspecific lower back pain in daily outpatient practice (the NEURO-N study)

Authors:

Yakupov E.Z., Burd S.G., Barantsevich E.R., Gamieva R.A., Mendel O.I., Lebedeva A.V., Rubleva Y.V., Pantina N.V., Bokitko T.A., Kovaleva I.I., Bogomazova M.A., Efimenko A.P., Smochilin A.G.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(11): 158‑164

DOI: 10.17116/jnevro2024124111158

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Table of contents

THE RESULTS OF A MULTICENTER OPEN OBSERVATIONAL STUDY OF THE EFFICACY AND SAFETY OF THE DIETARY SUPPLEMENT NEURURIDINE N IN PATIENTS WITH ACUTE NONSPECIFIC LOWER BACK PAIN IN DAILY OUTPATIENT PRACTICE (THE NEURO-N STUDY)
THE RESULTS OF A MULTICENTER OPEN OBSERVATIONAL STUDY OF THE EFFICACY AND SAFETY OF THE DIETARY SUPPLEMENT NEURURIDINE N IN PATIENTS WITH ACUTE NONSPECIFIC LOWER BACK PAIN IN DAILY OUTPATIENT PRACTICE (THE NEURO-N STUDY)

To cite this article:

Yakupov EZ, Burd SG, Barantsevich ER, et al. . The results of a multicenter open observational study of the efficacy and safety of the dietary supplement Neururidine N in patients with acute nonspecific lower back pain in daily outpatient practice (the NEURO-N study). S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(11):158‑164. (In Russ.)
https://doi.org/10.17116/jnevro2024124111158

 
 
Подписка 2025-2 (S.S. Korsakov Journal of Neurology and Psychiatry)
 
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OBJECTIVE

To study the efficacy and safety of the use of high (200 mg) doses of uridine monophosphate in combination with choline (dietary supplement, dietary supplement, Neururidine N) in the treatment of patients with nonspecific back pain.

MATERIAL AND METHODS

An open observational study was conducted, which included 101 patients with acute PB; group 1 included 65 patients who received Neurouridine N (1 caps/day) meloxicam (7.5—15 mg/day) and meloxicam (7.5—15 mg/day), 2nd — 36 patients who received only meloxicam (7.5—15 mg/day). The observation period is 30 days. The condition of the patients was assessed on the basis of a visual analog scale (VAS), Roland—Morris questionnaires (ORM) and general clinical impression (CGI).

RESULTS

The positive effect of treatment on reducing the severity of pain was noted according to the results of the VAS assessment. In patients of group 1, an earlier improvement in functional status was noted (starting from day 7) according to ORM data (p<0.01), A more pronounced decrease in pain intensity allowed patients of group 1 to stop taking NSAIDs after 14 days (p<0.01). Patients of the 1st group were statistically significantly more satisfied with the results of treatment (CGI questionnaire), the doctors who observed them also regarded the improvement in their condition as more significant compared to the 2nd group.

CONCLUSION

The use of dietary supplement Neururidine N is an effective and safe method of coanalgesic therapy in patients with acute LBP.

Keywords:

treatment of pain
low back pain
uridine monophosphate
choline
Neurouridine N

Authors:

Yakupov E.Z.

LLC «Scientific research Medical Complex «Your Health»

Burd S.G.

Pirogov Russian National Research Medical University (Pirogovsky University);
Federal Center of Brain and Neurotechnologies

Barantsevich E.R.

Academian I.P. Pavlov First Saint Petersburg State Medical University

Gamieva R.A.

LLC «Scientific research Medical Complex «Your Health»

Mendel O.I.

LLC «Unipharm»

Lebedeva A.V.

Pirogov Russian National Research Medical University (Pirogovsky University);
Federal Center of Brain and Neurotechnologies

Rubleva Y.V.

Federal Center of Brain and Neurotechnologies

Pantina N.V.

Federal Center of Brain and Neurotechnologies

Bokitko T.A.

Federal Center of Brain and Neurotechnologies

Kovaleva I.I.

Federal Center of Brain and Neurotechnologies

Bogomazova M.A.

Federal Center of Brain and Neurotechnologies

Efimenko A.P.

Federal Center of Brain and Neurotechnologies

Smochilin A.G.

Academian I.P. Pavlov First Saint Petersburg State Medical University

Received:

11.10.2024

Accepted:

14.10.2024

List of references:

  1. Kukushkin ML, Reshetnyk VK. Purynergic mechanisms of pain and analgesia. Russian Journal of Pain. 2019;17(1):51-56. (In Russ.). https://doi.org/10.25731/RASP.2019.01.09
  2. Nakatsuka T, Mena N, Ling J, Gu JG. Depletion of substance P from rat primary sensory neurons by ATP, an implication of P2X receptor-mediated release of substance P. Neurosci. 2001;107(2):293-300. 
  3. Amelin AV, Afanasiev VV, Barantsevich ER, et al.Pyrimidine nucleotides in pain management.Consensus of the international group of specialists. Russian Journal of Pain. 2023;21(1):78-84. (In Russ.). https://doi.org/10.17116/pain20232101178
  4. Goldberg H, Mibielli MA, Nunes CP, et al. A double-blind, randomized, comparative study of the use of a combination of uridine triphosphate trisodium, cytidine monophosphate disodium, and hydroxocobalamin, versus isolated treatment with hydroxocobalamin, in patients presenting with compressive neuralgias. J Pain Res. 2017;10:397-404.  https://doi.org/10.2147/JPR.S123045
  5. Negrão L, Almeida P, Alcino S, et al. Effect of the combination of uridine nucleotides, folic acid and vitamin B12 on the clinical expression of peripheral neuropathies. Pain Manag. 2014;4(3):191-196.  https://doi.org/10.2217/pmt.14.10
  6. Yakupov EZ, Troshina YV, Kashapova AO, et al. Results of observational study in the Russian Federation of the efficacy and safety of high doses of supplement “Neurouridine” (combination of uridine monophosphate (150 mg) with choline) in the treatment of patients with nonspecific low back pain. S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(9):53-59.(In Russ.). https://doi.org/10.17116/jnevro202012009153
  7. Yakupov EZ, Troshina YV, Gainutdinova RR, Kashapova AO. The results of a study on the safety of the dietary supplement neurouridine in patients with nonspecific low back pain (MULTINEURO-2). S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(3):52-56. (In Russ.). https://doi.org/10.17116/jnevro202112103152
  8. Yakupov EZ, Troshina YV, Gainutdinova RR, Kashapova AO. Evaluation of the efficacy and safety of the neuroprotective complex Neurouridin in patients with back pain. S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(6):46-51. (In Russ.). https://doi.org/10.17116/jnevro202112106146
  9. Danilov AB, Davydov OS. Neuropathic pain epidemiology. Pain. 2007;4(17):12-16. (In Russ.).
  10. Schaefer C, Mann R, Sadosky A, et al. Burden of Illness Associated with Peripheral and Central Neuropathic Pain among Adults Seeking Treatment in the United States: A Patient-Centered Evaluation. Pain Med. 2014;15(12):2105-2119.
  11. Mick G, Serpell M, Baron R, et al. Localised neuropathic pain in the primary care setting: a cross-sectional study of prevalence, clinical characteristics, treatment patterns, quality of life and sleep performance. Curr Med Res Opin. 2021;37(2):293-302. 
  12. Mibielli MA, Nunes CP, Scussel Jr. AB. Symptomatic improvement in an acute, non-traumatic spine pain model with a combination of uridine triphosphate, cytidine monophosphate, and hydroxocobalamin. Pain Studies Treat. 2014;2(1):6-10.  https://doi.org/10.4236/pst.2014.21002
  13. Burnstock G. Purinergic signalling: past, present and future. Braz J Med Biol Res. 2009;42(1):3-8.  https://doi.org/10.1590/S0100-879X2008005000037

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