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Bogolepova A.N.

Pirogov Russian National Research Medical University;
Federal Center of Brain Research and Neurotechnologies of the Federal Medical Biological Agency

Makhnovich E.V.

Pirogov Russian National Research Medical University;
Federal Center of Brain Research and Neurotechnologies

Kovalenko E.A.

Pirogov Russian National Research Medical University;
Federal Center of Brain Research and Neurotechnologies

Osinovskaya N.A.

Federal Center of Brain Research and Neurotechnologies

Beregov M.M.

Federal Center of Brain Research and Neurotechnologies

Features of neuropsychological status and results of magnetic resonance morphometry in patients with Alzheimer’s disease and glaucoma

Authors:

Bogolepova A.N., Makhnovich E.V., Kovalenko E.A., Osinovskaya N.A., Beregov M.M.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2023;123(9): 43‑51

DOI: 10.17116/jnevro202312309143

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Table of contents

FEATURES OF NEUROPSYCHOLOGICAL STATUS AND RESULTS OF MAGNETIC RESONANCE MORPHOMETRY IN PATIENTS WITH ALZHEIMER’S DISEASE AND GLAUCOMA
FEATURES OF NEUROPSYCHOLOGICAL STATUS AND RESULTS OF MAGNETIC RESONANCE MORPHOMETRY IN PATIENTS WITH ALZHEIMER’S DISEASE AND GLAUCOMA

To cite this article:

Bogolepova AN, Makhnovich EV, Kovalenko EA, Osinovskaya NA, Beregov MM. Features of neuropsychological status and results of magnetic resonance morphometry in patients with Alzheimer’s disease and glaucoma. S.S. Korsakov Journal of Neurology and Psychiatry. 2023;123(9):43‑51. (In Russ.)
https://doi.org/10.17116/jnevro202312309143

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
 
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Abstract:

OBJECTIVE

To identify the relationship of neuropsychological changes in patients with Alzheimer’s disease (AD) and primary open-angle glaucoma (POAG) and to evaluate the results of magnetic resonance (MR)-morphometry in patients with these diseases.

MATERIAL AND METHODS

We examined 32 patients (median age 67 [61.25; 76.75] years, 78.1% women) diagnosed with AD and POAG. The patients were divided into the AD group (n=16) and the POAG group (n=16). Complaints and anamnesis were collected for all patients, neurological status and neuropsychological status were assessed. MRI of the brain, followed by morphometry, was performed.

RESULTS

Cognitive impairments (CI) were revealed in patients of both groups. The severity of CI in patients with AD was more pronounced than in patients with POAG (p<0.001). Alzheimer’s type of CI was detected in both groups. MR-morphometry revealed a decrease in the volume of the left hippocampus, the volume of the right and left amygdala as well as a decrease in the thickness of the right and left entorhinal cortex in the AD group compared with the POAG group (p<0.05). A significant decrease in the thickness of the right medial orbitofrontal cortex was found in the POAG group compared with the AD group (p<0.05).

CONCLUSION

In AD and POAG, there is a similarity of the neuropsychological profile, which reflects the neurodegeneration characteristic of these diseases. MRI morphometry requires an assessment of both volumes and thickness of brain structures. A neuroimaging pattern identified in patients with POAG can be regarded as an indicator of the glaucomatous process.

Keywords:

dementia
cognitive impairment
Alzheimer’s disease
neuropsychological status
primary open-angle glaucoma
early diagnosis
magnetic resonance imaging
morphometry

Authors:

Bogolepova A.N.

Pirogov Russian National Research Medical University;
Federal Center of Brain Research and Neurotechnologies of the Federal Medical Biological Agency

Makhnovich E.V.

Pirogov Russian National Research Medical University;
Federal Center of Brain Research and Neurotechnologies

Kovalenko E.A.

Pirogov Russian National Research Medical University;
Federal Center of Brain Research and Neurotechnologies

Osinovskaya N.A.

Federal Center of Brain Research and Neurotechnologies

Beregov M.M.

Federal Center of Brain Research and Neurotechnologies

Received:

13.04.2023

Accepted:

19.04.2023

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