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Bogolepova A.N.

Pirogov Russian National Research Medical University;
Federal Center of Brain Research and Neurotechnologies of the Federal Medical Biological Agency

Features of pharmacotherapy of vascular cognitive impairment in the elderly

Authors:

Bogolepova A.N.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2023;123(9): 15‑20

DOI: 10.17116/jnevro202312309115

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FEATURES OF PHARMACOTHERAPY OF VASCULAR COGNITIVE IMPAIRMENT IN THE ELDERLY
FEATURES OF PHARMACOTHERAPY OF VASCULAR COGNITIVE IMPAIRMENT IN THE ELDERLY

To cite this article:

Bogolepova AN. Features of pharmacotherapy of vascular cognitive impairment in the elderly. S.S. Korsakov Journal of Neurology and Psychiatry. 2023;123(9):15‑20. (In Russ.)
https://doi.org/10.17116/jnevro202312309115

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The problem of pharmacotherapy of elderly and senile people is currently extremely relevant due to the aging of the population and the increase in the prevalence of cardiovascular diseases. One of the most serious problems of the elderly is the development of cognitive decline due to cerebrovascular pathology. However, elderly patients often have a large number of comorbid diseases, which leads to difficulties in diagnosing and managing these patients, and often to the development of polypharmacy, which can lead to deterioration in functional status, cognitive impairment, adverse reactions and drug interactions. In addition, in elderly patients, there may be changes in pharmacokinetics and pharmacodynamics due to anatomical and physiological involutive processes. At the same time, the number of drugs whose clinical efficacy and tolerability were evaluated specifically in elderly and senile patients is relatively small. In a randomized clinical trial of sequential parenteral and oral therapy with Mexidol in patients with mild vascular cognitive impairment syndrome, a positive effect of this therapy on various domains (cognitive, emotional, autonomic, motor) of chronic cerebrovascular disease was confirmed compared with placebo, which allows us to recommend it for use in elderly and senile patients.

Keywords:

vascular cognitive impairment
elderly patient
pharmacotherapy
ethylmethylhydroxyperidine succinate
Mexidol

Authors:

Bogolepova A.N.

Pirogov Russian National Research Medical University;
Federal Center of Brain Research and Neurotechnologies of the Federal Medical Biological Agency

Received:

01.06.2023

Accepted:

18.07.2023

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