Oxidative stress in the pathogenesis of stroke and its correction

Martynov M.Yu.; Zhuravleva M.V.; Vasyukova N.S.; Kuznetsova E.V.; Kameneva T.R.

doi:https://doi.org/10.17116/jnevro202312301116

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Abstract:

We reviewed the role of oxidative stress (OS) in the pathogenesis of ischemic (IS) and hemorrhagic stroke (HS). OS plays a major role in programmed cell death, increased permeability of the blood-brain barrier, astroglial and microglial activation, and local inflammatory response. We also reviewed the current state of neuro- and cytoprotection studies and their translation in clinical practice. With respect to experimental and clinical data the efficacy of long term administration of multimodal cytoprotective drug with antioxidant effect — ethylmethylhydroxypyridine succinate (Mexidol) is discussed during the acute and early recovery period after stroke.

Keywords:

stroke

reperfusion

oxidative stress

programmed cell death

apoptosis

ferroptosis

hemoglobin

neuroprotection

ethylmethylhydroxypyridine succinate

Mexidol

Authors:

Martynov M.Yu.

Pirogov Russian National Research Medical University;
Federal Center of Brain Research and Neurotechnology of the Federal Medical Biological Agency

SPIN RSCI: 8010-8340
Scopus AuthorID: 7004761286
ResearcherID: K-8390-2018
ORCID: 0000-0003-2797-7877

Zhuravleva M.V.

I.M. Sechenov First Moscow State Medical University (Sechenov University);
Scientific Centre of Medical Application Expertise of the Ministry of the Healthcare of the Russian Federation

ORCID: 0000-0002-9198-8661

Vasyukova N.S.

Federal Scientific Center-all-Russian Research Skriabin and Kovalenko Institute of Experimental Veterinary Medicine the Russian Academy of Sciences

Kuznetsova E.V.

Research Institute for Healthcare and Medical Management

Kameneva T.R.

Konchalovsky City Clinical Hospital

Received:

16.01.2023

Accepted:

17.01.2023

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