Clinical-neurobiological correlations in young depressive patients with a history of suicidal attempts

Iznak A.F.

Mental Health Research Centre

Klyushnik T.P.

Mental Health Research Center

ORCID: 0000-0001-5148-3864

Zozulya S.A.

Mental Health Research Center

ORCID: 0000-0001-5390-6007

Iznak E.V.

Mental Health Research Centre

Oleĭchik I.V.

Mental Health Research Centre

Clinical-neurobiological correlations in young depressive patients with a history of suicidal attempts

Authors:

Iznak A.F., Klyushnik T.P., Zozulya S.A., Iznak E.V., Oleĭchik I.V.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(11): 105‑109

DOI: 10.17116/jnevro2022122111105

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To cite this article:

Iznak AF, Klyushnik TP, Zozulya SA, Iznak EV, Oleĭchik IV. Clinical-neurobiological correlations in young depressive patients with a history of suicidal attempts. S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(11):105‑109. (In Russ.)
https://doi.org/10.17116/jnevro2022122111105

Подписка 2025-2 (S.S. Korsakov Journal of Neurology and Psychiatry)

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OBJECTIVE

Is to identify the relationships of quantitative clinical, EEG and neuroimmunological parameters in young female patients with depression and a history of suicidal attempts in order to clarify the role of neuroimmune interaction in the pathogenesis of suicidal behavior.

MATERIAL AND METHODS

In 35 female patients aged 16—25 years the pre-treatment severity of the depressive state was quantitatively assessed (according to the HDRS-17 scale), and immunological parameters — markers of neuroinflammation (activity of leukocyte elastase and of α1-proteinase inhibitor) in blood plasma using the laboratory technology «Neuro-immuno-test» and the EEG absolute spectral power in narrow frequency sub-bands were measured. The relationships between clinical, neuroimmunological and EEG parameters was determined by correlation analysis (according to Spearman).

RESULTS

The values of immunological markers of neuroinflammation correlated with EEG signs of increased activation of the cerebral cortex and with the severity of the anxiety component of the depressive state.

CONCLUSION

The structure of clinical-neurobiological correlations in the examined patients indicates the involvement of neuroinflammation processes in the pathogenesis of their condition. The results make it possible to clarify the neurobiological factors of the pathogenesis of suicidal behavior in young depressive patients.

Keywords:

depression

young age

suicidal attempts

quantitative EEG

neuroimmunology

Authors:

Iznak A.F.

Mental Health Research Centre

Klyushnik T.P.

Mental Health Research Center

ORCID: 0000-0001-5148-3864

Zozulya S.A.

Mental Health Research Center

ORCID: 0000-0001-5390-6007

Iznak E.V.

Mental Health Research Centre

Oleĭchik I.V.

Mental Health Research Centre

Received:

21.06.2022

Accepted:

20.07.2022

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