Changes in adipokines in the blood of patients with the first episode of schizophrenia during treatment with haloperidol and risperidone

Ozornin A.S.; Govorin N.V.; Sakharov A.V.; Tereshkov P.P.

doi:https://doi.org/10.17116/jnevro202112109158

Ozornin A.S.

Chita State Medical Academy;
Kandinsky Territorial Clinical Psychiatric Hospital

Govorin N.V.

State Duma Of The Federal Assembly Of The Russian Federation

Sakharov A.V.

Chita State Medical Academy

Tereshkov P.P.

The Chita State Medical Academy

Changes in adipokines in the blood of patients with the first episode of schizophrenia during treatment with haloperidol and risperidone

Authors:

Ozornin A.S., Govorin N.V., Sakharov A.V., Tereshkov P.P.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(9): 58‑62

DOI: 10.17116/jnevro202112109158

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To cite this article:

Ozornin AS, Govorin NV, Sakharov AV, Tereshkov PP. Changes in adipokines in the blood of patients with the first episode of schizophrenia during treatment with haloperidol and risperidone. S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(9):58‑62. (In Russ.)
https://doi.org/10.17116/jnevro202112109158

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)

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OBJECTIVE

To study plasma adipokines (adiponectin, leptin, adipsin) in patients with the first episode of schizophrenia treated with haloperidol and risperidone.

MATERIAL AND METHODS

Two hundred and twelve patients with the first episode of paranoid schizophrenia (F20.09) were examined. Patients were divided into the haloperidol group (n=107) and the risperidone group (n=105). The control group included 132 healthy people. Body mass index was recorded at baseline and in 2, 4, 6, 8 week of treatment. Adiponectin, adipsin and leptin were determined by the multiplex analysis. Blood test was conducted prior to therapy and after 8 weeks of treatment.

RESULTS

An increase in body mass index is recorded in both clinical groups, with no statistically significant differences between groups. Before treatment with antipsychotics, the levels of adiponectin and adipsin increase in both clinical groups. In the course of therapy, the levels of adiponectin and adipsin significantly increase in the haloperidol group and the levels of adiponectin and leptin in the risperidone group.

CONCLUSION

The increase in body weight is not the only mechanism of changes in adipokines in blood during treatment with antipsychotics. Further studies on the relationship between the levels of adipokines and pharmacogenic metabolic disorders are required.

Keywords:

schizophrenia

antipsychotics

adiponectin

adipsin

leptin

Authors:

Ozornin A.S.

Chita State Medical Academy;
Kandinsky Territorial Clinical Psychiatric Hospital

Govorin N.V.

State Duma Of The Federal Assembly Of The Russian Federation

Sakharov A.V.

Chita State Medical Academy

Tereshkov P.P.

The Chita State Medical Academy

Received:

24.08.2020

Accepted:

03.11.2020

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References:

Ozornin AS, Ozornina NV, Govorin NV. Changes of lipid peroxidation and content of the erythrocyte membrane fatty acids in patients with paranoid schizophrenia. Rossiiskii psikhiatricheskii zhurnal. 2017;2:47-53. (In Russ.).
Pillinger T, Beck K, Gobjila C, Donocik JG, Jauhar S, Howes OD. Impaired Glucose Homeostasis in First-Episode Schizophrenia: A Systematic Review and Meta-analysis. JAMA Psychiatry. 2017;74(3):261-269. https://doi.org/10.1001/jamapsychiatry.2016.3803
Emsley R, Kilian S, Phahladira L. How long should antipsychotic treatment be continued after a single episode of schizophrenia? Curr Opin Psychiatry. 2016;29(3):224-229. https://doi.org/10.1097/YCO.0000000000000249
Naderyan Fe’li S, Yassini Ardekani SM, Fallahzadeh H, Dehghani A. Metabolic syndrome and 10-year risk of cardiovascular events among schizophrenia inpatients treated with antipsychotics. Med J Islam Repub Iran. 2019;33:97.
Sveklina TS, Talantzeva MS, Barsukov AV. The metabolic syndrome and inflammation: actual issues of pathogenesis. Klinicheskaya laboratornaya diagnostika. 2013;3:7-10. (In Russ.).
Beumer W, Drexhage RC, De Wit H, Versnel MA, Drexhage HA, Cohen D. Increased level of serum cytokines, chemokines and adipokines in patients with schizophrenia is associated with disease and metabolic syndrome. Psychoneuroendocrinology. 2012;37(12):1901-1911. https://doi.org/10.1016/j.psyneuen.2012.04.001
Song X, Fan X, Song X, Zhang J, Zhang W, Li X, Gao J, Harrington A, Ziedonis D, Lv L. Elevated levels of adiponectin and other cytokines in drug naïve, first episode schizophrenia patients with normal weight. Schizophr Res. 2013;150(1):269-273. https://doi.org/10.1016/j.schres.2013.07.044
Liu D, Luo S, Li Z. Multifaceted roles of adiponectin in rheumatoid arthritis. Int Immunopharmacol. 2015;28(2):1084-1090. https://doi.org/10.1016/j.intimp.2015.08.013
Tay YH, Lee J. The relationship between serum adiponectin levels, cardiometabolic indices and metabolic syndrome in schizophrenia. Asian J Psychiatr. 2019;43:1-6. https://doi.org/10.1016/j.ajp.2019.04.006
Juncal-Ruiz M, Riesco-Dávila L, Ortiz-García de la Foz V, Martínez-Garcia O, Ramírez-Bonilla M, Ocejo-Viñals JG, Leza JC, López-Hoyos M, Crespo-Facorro B. Comparison of the anti-inflammatory effect of aripiprazole and risperidone in 75 drug-naïve first episode psychosis individuals: A 3 months randomized study. Schizophr Res. 2018;202:226-233. https://doi.org/10.1016/j.schres.2018.06.039
Żółkiewicz J, Stochmal A, Rudnicka L. The role of adipokines in systemic sclerosis: a missing link? Arch Dermatol Res. 2019;311(4):251-263. https://doi.org/10.1007/s00403-019-01893-1
Guo D, Yuan Y, Huang R, Tian S, Wang J, Lin H, An K, Han J, Wang S. Association between plasma adipsin level and mild cognitive impairment in Chinese patients with type 2 diabetes: a cross-sectional study. BMC Endocr Disord. 2019;19(1):108. https://doi.org/10.1186/s12902-019-0431-y
Pisano S, Coppola G, Catone G, Carotenuto M, Iuliano R, D’Esposito V, Cabaro S, Miraglia Del Giudice E, Bravaccio C, Formisano P. Differences in Metabolic Factors Between Antipsychotic-Induced Weight Gain and Non-pharmacological Obesity in Youths. Clin Drug Investig. 2018;38(5):457-462. https://doi.org/10.1007/s40261-018-0627-3
Vasilenko MA, Kirienkova EV, Skuratovskaia DA, Zatolokin PA, Mironyuk NI, Litvinova LS. The role of production of adipsin and leptin in the development of insulin resistance in patients with abdominal obesity. Doklady akademii nauk. 2017;475(3):336-341. (In Russ.).
Misiak B, Bartoli F, Stramecki F, Samochowiec J, Lis M, Kasznia J, Jarosz K, Stańczykiewicz B. Appetite regulating hormones in first-episode psychosis: A systematic review and meta-analysis. Neurosci Biobehav Rev. 2019;102:362-370. https://doi.org/10.1016/j.neubiorev.2019.05.018
Martorell L, Muntané G, Porta-López S, Moreno I, Ortega L, Montalvo I, Sanchez-Gistau V, Monseny R, Labad J, Vilella E. Increased levels of serum leptin in the early stages of psychosis. J Psychiatr Res. 2019;111:24-29. https://doi.org/10.1016/j.jpsychires.2019.01.006
Balõtšev R, Haring L, Koido K, Leping V, Kriisa K, Zilmer M, Vasar V, Piir A, Lang A, Vasar E. Antipsychotic treatment is associated with inflammatory and metabolic biomarkers alterations among first-episode psychosis patients: A 7-month follow-up study. Early Interv Psychiatry. 2019;13(1):101-109. https://doi.org/10.1111/eip.12457
Chen VC, Chen CH, Chiu YH, Lin TY, Li FC, Lu ML. Leptin/Adiponectin ratio as a potential biomarker for metabolic syndrome in patients with schizophrenia. Psychoneuroendocrinology. 2018;92:34-40. https://doi.org/10.1016/j.psyneuen.2018.03.021
Potvin S, Zhornitsky S, Stip E. Antipsychotic-induced changes in blood levels of leptin in schizophrenia: a meta-analysis. Can J Psychiatry. 2015;60(3 suppl 2):26-34.