Multimodal therapeutic strategies in the treatment of cerebrovascular disease

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The review presents the scientific substantiation of the relationship between age-related cerebrovascular changes and dysregulation of cerebral perfusion, blood-brain barrier (BBB) function and neurovascular units. The ischemic cascade in cerebrovascular disease (CVD) is considered, the main links of which are glutamate excitoxicosis, oxidative stress and neuroinflammation. Endothelial dysfunction and increased BBB permeability play an important role in the development of neuroinflammation. The use of multifunctional drugs aimed at various pathological targets of acute and chronic cerebral ischemia for the purpose of neuroprotection has been substantiated. These drugs include the peptide Cortexin (cattle cerebral cortex polypeptides). Experimental data on the study of its molecular partners in the brain are presented. The clinical efficacy of Cortexin as a neuroprotective drug in CVD has been established in many studies.

Keywords:

cerebrovascular disease

ischemic cascade

endothelial dysfunction

multifunctional drugs

Cortexin

Authors:

Fedin A.I.

Pirogov Russian National Research Medical University

RSCI AuthorID: 167799
Scopus AuthorID: 7007163263
ORCID: 0000-0002-6996-2828

Saverskaya E.N.

Medical Continuing Education Institute of the Moscow State Food Production University

Badalyan K.R.

Pirogov Russian National Research Medical University

Received:

12.11.2021

Accepted:

17.11.2021

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