Influence of cardiorespiratory training program on the intercellular adhesion molecule level in patients with postmastectomy syndrome

doi:https://doi.org/10.17116/kurort202410104145

Journal: . 2024;101(4): 45‑51

DOI: 10.17116/kurort202410104145

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Influence of cardiorespiratory training program on the intercellular adhesion molecule level in patients with postmastectomy syndrome. . 2024;101(4):45‑51. (In Russ.)
https://doi.org/10.17116/kurort202410104145

Подписка 2026 Вопросы курортологии, физиотерапии и лечебной физической культуры (Problems of Balneology, Physiotherapy and Exercise Therapy)

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OBJECTIVE

To evaluate the influence of 12-week aerobic dynamic training program of moderate intensity on the endothelial dysfunction laboratory markers and life quality in patients with PMS.

MATERIAL AND METHODS

Single-center prospective randomized trial included 40 patients with PMS divided into study (20 patients) and comparative (20 patients) groups, as well as 20 healthy female volunteers. The expression level of soluble intercellular adhesion molecule-1 (ICAM-1) and platelet endothelial cell adhesion molecule-1 (PECAM-1) were evaluated in all participants at baseline by enzyme-linked immunosorbent assay method, and additionally psychological and physical component of health by SF-36 questionnaire were assessed in patients with PMS.

Patients of study group received a course of 12-week partially controlled aerobic dynamic training of moderate intensity lasting 45 minutes with frequency equal 5 times per week. Patients with PMS were re-evaluated for ICAM-1 and PECAM-1, as well as for life quality.

RESULTS

The group of patients with PMS after BC treatment had increased level of ICAM-1 in long-term period, that may indicate endothelial dysfunction. Statistically significant decrease of endothelial dysfunction laboratory markers was revealed in patients with PMS, who underwent the course of cardiorespiratory training. In the same time, the dynamics of changes in ICAM-1 was higher in the study group than in comparative group. Further, improvement of physical and psychological components of health by SF-36 questionnaire was found.

CONCLUSIONS

The program of cardiorespiratory trainings of moderate intensity in patients, who had BC treatment a year ago, decreases intercellular adhesion molecules level that may show an improvement of endothelial dysfunction.

Keywords:

postmastectomy syndrome

endothelial dysfunction

aerobic trainings

breast cancer

Received:

07.11.2023

Accepted:

13.05.2024

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References:

Coughlin SS. Epidemiology of Breast Cancer in Women. Adv Exp Med Biol. 2019;1152:9-29. https://doi.org/10.1007/978-3-030-20301-6_2
Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians. 2018;68(6):394-424. https://doi.org/10.3322/caac.21492
Shikhkerimov RK, Velsher LZ, Stakhanov ML, Stulin ID, Savin AA, Savin LA, Strazhev CB, Shikhkerimov RK, Koychakaeva AS, Lochan NV, Lyseyko NV, Antonyuk MV. Postmastectomy syndrome as a multidisciplinary problem. Oncosurgery. 2008;1:90-95. (In Russ.).
Iarygin ML, Obmanov IV, Iarygin LM, Khokhlov AA, Shmyrev VI. Postmastectomy syndrome after the radical treatment of the breast cancer with the preservation of the intercostal nerve. Pirogov Russian Journal of Surgery. 2013;8:25-27. (In Russ.).
Koul R, Dufan T, Russell C, Guenther W, Nugent Z, et al. Efficacy of complete decongestive therapy and manual lymphatic drainage on treatment-related lymphedema in breast cancer. Int J Radiat Oncol Biol Phys. 2007;67(3):841-846. https://doi.org/10.1016/j.ijrobp.2006.09.024
Agostini F, Attanasi C, Bernetti A, et al. Web Axillary Pain Syndrome-Literature Evidence and Novel Rehabilitative Suggestions: A Narrative Review. Int J Environ Res Public Health. 2021;18(19):10383. https://doi.org/10.3390/ijerph181910383
Chappell AG, Yuksel S, Sasson DC, et al. Post-Mastectomy Pain Syndrome: An Up-to-Date Review of Treatment Outcomes. JPRAS Open. 2021;30:97-109. https://doi.org/10.1016/j.jpra.2021.07.006
Kirichenko YY, Belenkov YN, Privalova EV, Naymann YI, Gitel EP, Novikova OV, Ilgisonis IS. Vasculotoxicity of Chemotherapy: Assessment of Endothelial Dysfunction Biomarkers’ Levels in Gastric Cancer Patients. Kardiologiia. 2020;60(5):1069. https://doi.org/10.18087/cardio.2020.5.n1069
Fredslund SO, Buus NH, Højgaard Skjold C, et al. Changes in vascular function during breast cancer treatment. Br J Clin Pharmacol. 2021;87(11):4230-4240. https://doi.org/10.1111/bcp.14837
Ravi P, Vaishnavi D, Gnanam A, et al. The role of hyperbaric oxygen therapy in the prevention and management of radiation-induced complications of the head and neck ‒ a systematic review of literature. J Stomatol Oral Maxillofac Surg. 2017;118(6):359-362. https://doi.org/10.1016/j.jormas.2017.07.005
Qiu S, Cai X, Yin H, et al. Exercise training and endothelial function in patients with type 2 diabetes: a meta-analysis. Cardiovasc Diabetol. 2018;17(1):64. https://doi.org/10.1186/s12933-018-0711-2
Pearson MJ, Smart NA. Effect of exercise training on endothelial function in heart failure patients: A systematic review meta-analysis. Int J Cardiol. 2017;231:234-243. https://doi.org/10.1016/j.ijcard.2016.12.145
Man AWC, Li H, Xia N. Impact of Lifestyles (Diet and Exercise) on Vascular Health: Oxidative Stress and Endothelial Function. Oxid Med Cell Longev. 2020;2020:1496462. https://doi.org/10.1155/2020/1496462
Demchenko EA, Vakhrameeva NV, Butomo MI. Detection of endothelial dysfunction in patients with exertional angina: comparison of the exercise test and the test with reactive hyperemia. Bulletin of arrhythmology. 2006;41:33-38. (In Russ).
Boutcher YN, Boutcher SH. Exercise intensity and hypertension: what’s new? J Hum Hypertens. 2017;31(3):157-164. https://doi.org/10.1038/jhh.2016.62
Beaudry RI, Liang Y, Boyton ST, et al. Meta-analysis of Exercise Training on Vascular Endothelial Function in Cancer Survivors. Integr Cancer Ther. 2018;17(2):192-199. https://doi.org/10.1177/1534735418756193
Federal’nye klinicheskie rekomendacii po diagnostike i lecheniyu postmastektomicheskogo sindroma. Moskovskij nauchno-issledovatel’skij onkologicheskij institut im. P.A. Gercena Minzdrava Rossii. Moskva; 2013. Accessed August 30, 2023. https://rehabrus.ru/Docs/2020/Postatomsindr.pdf
Pak L, Noso Y, Chaizhunusova N, et al. Disorder of endothelia vessels functional state with malignant tumors in patients exposed anthropogenic radiation. Asian Pac J Cancer Prev. 2016:17(2):575-579.
Terwoord JD, Beyer AM, Gutterman DD. Endothelial dysfunction as a complication of anti-cancer therapy. Pharmacol Ther. 2022;237:108116. https://doi.org/10.1016/j.pharmthera.2022.108116
Jones LW, Fels DR, West M, et al. Modulation of circulating angiogenic factors and tumor biology by aerobic training in breast cancer patients receiving neoadjuvant chemotherapy. Cancer Prev Res (Phila). 2013;6(9):925-937. https://doi.org/10.1158/1940-6207.CAPR-12-0416
Shcheblykin DV, Bolgov AA, Pokrovskii MV, Stepenko YuV, Tsuverkalova YuM, Shcheblykina OV, Golubinskaya PA, Korokina LV Endothelial dysfunction: developmental mechanisms and therapeutic strategies. Research Results in Pharmacology. 2022;8(4):115-139. https://doi.org/10.3897/rrpharmacology.8.80376
Wolff G, Toborek M. Targeting the therapeutic effects of exercise on redox-sensitive mechanisms in the vascular endothelium during tumor progression. IUBMB Life. 2013;65(7):565-571. https://doi.org/10.1002/iub.1169
Aydin M, Kose E, Odabas I, et al. The Effect of Exercise on Life Quality and Depression Levels of Breast Cancer Patients. Asian Pac J Cancer Prev. 2021;22(3):725-732. https://doi.org/10.31557/APJCP.2021.22.3.725
Kulkarni N, Mahajan AA, Khatri SM. A randomized controlled trial of the effectiveness of aerobic training for patients with breast cancer undergoing radiotherapy. Phys Ther Sport. 2013;113:42-50.