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Katasonov A.B.

Mental Health Research Center

Gut microbiome as a therapeutic target in the treatment of depression and anxiety

Authors:

Katasonov A.B.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(11): 129‑135

DOI: 10.17116/jnevro2021121111129

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GUT MICROBIOME AS A THERAPEUTIC TARGET IN THE TREATMENT OF DEPRESSION AND ANXIETY
GUT MICROBIOME AS A THERAPEUTIC TARGET IN THE TREATMENT OF DEPRESSION AND ANXIETY

To cite this article:

Katasonov AB. Gut microbiome as a therapeutic target in the treatment of depression and anxiety. S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(11):129‑135. (In Russ.)
https://doi.org/10.17116/jnevro2021121111129

 
Подписка 2025-2 (S.S. Korsakov Journal of Neurology and Psychiatry)
 
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There is a bi-directional connection between the gut microbiome and the brain. Changes in the composition of the microbiome affect emotions, behavior, and the stress response involved in the pathogenesis of depression. Depression and anxiety are often associated with dysbiosis and inflammatory bowel disease. Dysbiosis enhances stress response and low-grade systemic inflammation, and vice versa. This vicious circle may be responsible for the formation of depression. Antidepressants therapy should be accompanied by the elimination of dysbiosis. For these purposes diet, prebiotics, probiotics and faecal microbiota transplantation can be used. The advantages and disadvantages of each method are considered. The manipulation of microbiome composition has been shown to have great therapeutic potential in the treatment of depression and anxiety.

Keywords:

microbiome
antidepressant
diet
prebiotic
probiotic
depression
anxiety

Authors:

Katasonov A.B.

Mental Health Research Center

Received:

26.07.2020

Accepted:

08.09.2020

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