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Popov V.V.

Scientific Medical Center, JSC «Russian Railways»;
Moscow State University of Food Production

Gildeeva G.N.

Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)

Butuzova D.V.

Medical Development Agency LLC

Ezhova E.A.

«Moscow Endocrine Plant»

Belostotskiy A.V.

Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)

Bulanova N.A.

Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)

A study of the efficacy and safety of lornoxicam in patients with acute sciatica

Authors:

Popov V.V., Gildeeva G.N., Butuzova D.V., Ezhova E.A., Belostotskiy A.V., Bulanova N.A.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(5): 42‑49

DOI: 10.17116/jnevro202012005142

Views: 3401

Downloaded: 146

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To cite this article:

Popov VV, Gildeeva GN, Butuzova DV, Ezhova EA, Belostotskiy AV, Bulanova NA. A study of the efficacy and safety of lornoxicam in patients with acute sciatica. S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(5):42‑49. (In Russ.)
https://doi.org/10.17116/jnevro202012005142

 
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OBJECTIVE

To compare the efficacy, safety and tolerability of lornoxicam and xefocam used as the reference drug in patients with acute nonspecific pain in lower back caused by acute sciatica.

MATERIAL AND METHODS

A simple blind clinical study was conducted with 108 patients (men and women, aged 20—55 years) with complaints of pain in the lower back and an established diagnosis of vertebrogenic radiculopathy L4, L5, S1. Patients were randomized into 2 treatment groups by randomization method of envelopes in the ratio of 1:1 (54 patients per group). The first group received lornoxicam in a dose of 16 mg/day for 2 days, the second group was treated with xefocam (the lyophilisate for preparation of solution for intravenous and intramuscular injection) according to a similar scheme.

RESULTS AND CONCLUSION

The results demonstrate the comparable efficacy of lornoxicam and the reference drug. The analysis of the safety profile reveals no significant differences between treatment groups.

Keywords:

acute nonspecific pain in lower back
efficacy
safety

Authors:

Popov V.V.

Scientific Medical Center, JSC «Russian Railways»;
Moscow State University of Food Production

Gildeeva G.N.

Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)

Butuzova D.V.

Medical Development Agency LLC

Ezhova E.A.

«Moscow Endocrine Plant»

Belostotskiy A.V.

Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)

Bulanova N.A.

Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)

Received:

28.06.2019

Accepted:

03.07.2019

List of references:

  1. Waddel G. The back pain revolution. Edinburg: Churchill Livingstone: 1998;438. 
  2. Pepelyanskiy YaYu. Orthopedic neurology (vertebrology). A guide for doctors. Medpress-inform, 2003;670. (In Russ.).
  3. Lyashenko EA, Zhezlov MA, Levin OS. Acute back pain: algorithms of diagnosis and therapy. Pharmateka. 2013;13:87-94. (In Russ.).
  4. Levin OS. Diagnosis and treatment of neurological manifestations of spinal osteochondrosis. Consilium Medicum. 2004;6:8. (In Russ.).
  5. Levin OS, Shtulman DR. Neurology: a reference practitioner. 9th ed., Ext. and pererabat. M.: Medpress-inform, 2013;183-200. (In Russ.).
  6. Grishaeva TP, Balabanova RM. The use of Xefocam (lornoxicam) for the relief of acute and chronic pain syndrome. Russian Medical Journal. 2005;15:1009. (In Russ.).
  7. Kukushkin ML, Tabeeva GR, Podchufarova EV. Pain syndrome: pathogenesis, clinic, treatment. Clinical recommendations. Ed. Acad. RAMS NN Yahno. M.: IMA-press, 2011;79. (In Russ.).
  8. Gildeeva GN, Belostotsky AV, Andreeva DM, Yurkov VI. Pharmacology as the basis of an interdisciplinary approach in the complex evaluation of medicines. Pharmacy. 2019;68(2):5-10. (In Russ.).
  9. Vorobieva OV. Back pain. Russian Medical Journal. 2003;11:10:94-98. (In Russ.).
  10. Khitrov NA. Shoulder pain and periarthritis of the shoulder joint: diagnosis and treatment. Polyclinic. 2015;1:40-46. (In Russ.).

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