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Proskurnina E.V.

M.V. Lomonosov Moscow State University, Moscow, Russia

Sokolova S.V.

Lomonosov Moscow State University, Moscow, Russia

Grishina N.K.

Lomonosov Moscow State University, Moscow, Russia

Sozarukova M.M.

Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Moscow, Russia

Gaifullin N.M.

Lomonosov Moscow State University, Moscow, Russia

Khannanova A.N.

Moskovskiĭ gosudarstvennyĭ mediko-stomatologicheskiĭ universitet

The functional activity of neutrophils in paranoid schizophrenia and Alzheimer’s disease

Authors:

Proskurnina E.V., Sokolova S.V., Grishina N.K., Sozarukova M.M., Gaifullin N.M., Khannanova A.N.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(4): 97‑101

DOI: 10.17116/jnevro202012004197

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Table of contents

THE FUNCTIONAL ACTIVITY OF NEUTROPHILS IN PARANOID SCHIZOPHRENIA AND ALZHEIMER’S DISEASE
THE FUNCTIONAL ACTIVITY OF NEUTROPHILS IN PARANOID SCHIZOPHRENIA AND ALZHEIMER’S DISEASE

To cite this article:

Proskurnina EV, Sokolova SV, Grishina NK, Sozarukova MM, Gaifullin NM, Khannanova AN. The functional activity of neutrophils in paranoid schizophrenia and Alzheimer’s disease. S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(4):97‑101. (In Russ.)
https://doi.org/10.17116/jnevro202012004197

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
МСФ на ЯМ
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Abstract:

Objective. To evaluate the radical-producing function of neutrophils in paranoid schizophrenia and Alzheimer’s disease. Material and methods. The study included 40 patients with paranoid schizophrenia and 22 with Alzheimer’s disease. To assess the functional activity of neutrophils, whole blood samples were analyzed using the chemiluminescent method with two-step cell stimulation. Indicators of radical-producing activity of neutrophils in patients were compared to those in age-matched healthy people. Results. The quantitative indicators of radical-producing activity of neutrophils in the paranoid schizophrenia group and in the Alzheimer’s disease group correspond to reference intervals of healthy donors, however almost one third of patients with paranoid schizophrenia had an altered shape of the chemiluminescent curve. Conclusion. The neutrophil immune response might be involved in the pathogenesis of paranoid schizophrenia only in some cases.

Keywords:

neutrophils
free radicals
chemiluminescence
paranoid schizophrenia
Alzheimer’s disease

Authors:

Proskurnina E.V.

M.V. Lomonosov Moscow State University, Moscow, Russia

Sokolova S.V.

Lomonosov Moscow State University, Moscow, Russia

Grishina N.K.

Lomonosov Moscow State University, Moscow, Russia

Sozarukova M.M.

Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Moscow, Russia

Gaifullin N.M.

Lomonosov Moscow State University, Moscow, Russia

Khannanova A.N.

Moskovskiĭ gosudarstvennyĭ mediko-stomatologicheskiĭ universitet

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References:

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