The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Proskurnina E.V.

M.V. Lomonosov Moscow State University, Moscow, Russia

Sokolova S.V.

Lomonosov Moscow State University, Moscow, Russia

Grishina N.K.

Lomonosov Moscow State University, Moscow, Russia

Sozarukova M.M.

Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Moscow, Russia

Gaifullin N.M.

Lomonosov Moscow State University, Moscow, Russia

Khannanova A.N.

Moskovskiĭ gosudarstvennyĭ mediko-stomatologicheskiĭ universitet

The functional activity of neutrophils in paranoid schizophrenia and Alzheimer’s disease

Authors:

Proskurnina E.V., Sokolova S.V., Grishina N.K., Sozarukova M.M., Gaifullin N.M., Khannanova A.N.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(4): 97‑101

DOI: 10.17116/jnevro202012004197

Views: 943

Downloaded: 29

Download PDF (RU)
Contact the author
Table of contents

To cite this article:

Proskurnina EV, Sokolova SV, Grishina NK, Sozarukova MM, Gaifullin NM, Khannanova AN. The functional activity of neutrophils in paranoid schizophrenia and Alzheimer’s disease. S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(4):97‑101. (In Russ.)
https://doi.org/10.17116/jnevro202012004197

 
МСФ на ЯМ
Close metadata
Recommended articles:
Glymphatic dysfunction and sleep diso­rders: indi­rect effe­cts on Alzheimer’s disease. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(4):7-12
Ginkgolide B: mechanisms of neurobiological effe­cts, prospects for use in the therapy of Alzheimer’s disease. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(4):22-27
Comparative characteristics of neuropsychological and neurometabolic changes in patients with Alzheimer’s disease and vascular cognitive impairment. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(4-2):17-24
Impairment of atte­ntion and executive functions in chro­nic cere­brovascular disease and Alzheimer’s disease. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(4-2):25-32
Asse­ssment of the significance of dila­ted peri­vascular spaces and nocture arte­rial hype­rtension in the deve­lopment of Alzheimer’s disease. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(4-2):33-40
EEG changes in patients with Alzheimer’s disease. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(4-2):72-76
Electroencephalographic differences in patients with para­noid schi­zophrenia with or without a history of suicide atte­mpts. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(5):113-119
The role of astrocytes, circadian rhythms and light pollution in the pathogenesis of Alzheimer’s disease. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(6):20-25
Immu­nological and neuroanatomic markers of the clinical dyna­mics of MCI and pre-MCI. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(8):81-91
Expe­rience of using the combined drug Mioreol in patients with Alzheimer’s disease and mixed deme­ntia. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(9):34-43

Objective. To evaluate the radical-producing function of neutrophils in paranoid schizophrenia and Alzheimer’s disease. Material and methods. The study included 40 patients with paranoid schizophrenia and 22 with Alzheimer’s disease. To assess the functional activity of neutrophils, whole blood samples were analyzed using the chemiluminescent method with two-step cell stimulation. Indicators of radical-producing activity of neutrophils in patients were compared to those in age-matched healthy people. Results. The quantitative indicators of radical-producing activity of neutrophils in the paranoid schizophrenia group and in the Alzheimer’s disease group correspond to reference intervals of healthy donors, however almost one third of patients with paranoid schizophrenia had an altered shape of the chemiluminescent curve. Conclusion. The neutrophil immune response might be involved in the pathogenesis of paranoid schizophrenia only in some cases.

Keywords:

neutrophils
free radicals
chemiluminescence
paranoid schizophrenia
Alzheimer’s disease

Authors:

Proskurnina E.V.

M.V. Lomonosov Moscow State University, Moscow, Russia

Sokolova S.V.

Lomonosov Moscow State University, Moscow, Russia

Grishina N.K.

Lomonosov Moscow State University, Moscow, Russia

Sozarukova M.M.

Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Moscow, Russia

Gaifullin N.M.

Lomonosov Moscow State University, Moscow, Russia

Khannanova A.N.

Moskovskiĭ gosudarstvennyĭ mediko-stomatologicheskiĭ universitet

List of references:

  1. Semenov SF. Some Clinical Characteristics and Course of Schizophrenia with Signs of Autoimmunization with Brain Antigens. Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova. 1964;64:398-403. (In Russ.).
  2. Sawa A, Sedlak TW. Oxidative stress and inflammation in schizophrenia. Schizophrenia research. 2016;176(1):1-2. https://doi.org/10.1016/j.schres.2016.06.014
  3. Muller N. Inflammation in Schizophrenia: Pathogenetic Aspects and Therapeutic Considerations. Schizophrenia bulletin. 2018;44(5):973-982. https://doi.org/10.1093/schbul/sby024
  4. Watkins CC, Andrews SR. Clinical studies of neuroinflammatory mechanisms in schizophrenia. Schizophrenia research. 2016;176(1):14-22. https://doi.org/10.1016/j.schres.2015.07.018
  5. Xia M, Abazyan S, Jouroukhin Y, Pletnikov M. Behavioral sequelae of astrocyte dysfunction: focus on animal models of schizophrenia. Schizophrenia research. 2016;176(1):72-82. https://doi.org/10.1016/j.schres.2014.10.044
  6. Harvey PD. Inflammation in Schizophrenia: What It Means and How to Treat It. The American journal of geriatric psychiatry: official journal of the American Association for Geriatric Psychiatry. 2017;25(1):62-63. https://doi.org/10.1016/j.jagp.2016.10.012
  7. Al-Hakeim HK, Al-Rammahi DA, Al-Dujaili AH. IL-6, IL-18, sIL-2R, and TNFalpha proinflammatory markers in depression and schizophrenia patients who are free of overt inflammation. Journal of affective disorders. 2015;182:106-114. https://doi.org/10.1016/j.jad.2015.04.044
  8. Ferrante A, Hii C, Hume D. Neutrophilic schizophrenia: breaching the barrier between innate and adaptive immunity. Immunology and cell biology. 2007;85(4):265-266. https://doi.org/10.1038/sj.icb.7100036
  9. Sirota P, Gavrieli R, Wolach B. Overproduction of neutrophil radical oxygen species correlates with negative symptoms in schizophrenic patients: parallel studies on neutrophil chemotaxis, superoxide production and bactericidal activity. Psychiatry research. 2003;121(2):123-132. https://doi.org/10.1016/S0165-1781(03)00222-1
  10. Semiz M, Yildirim O, Canan F, Demir S, Hasbek E, Tuman TC, Kayka N, Tosun M. Elevated neutrophil/lymphocyte ratio in patients with schizophrenia. Psychiatria Danubina. 2014;26(3):220-225. http://www.psychiatria-danubina.com/UserDocsImages/pdf/dnb_vol26_no3/dnb_vol26_no3_220.pdf
  11. Kulaksizoglu B, Kulaksizoglu S. Relationship between neutrophil/lymphocyte ratio with oxidative stress and psychopathology in patients with schizophrenia. Neuropsychiatric disease and treatment. 2016;12:1999-2005. https://doi.org/10.2147/NDT.S110484
  12. Klyushnik TP, Androsova LV, Simashkova NV, Zozulya SA, Otman IN, Shushpanova OV, Makarova LO, Dupin AM. Status of the immune system in the continuum of autistic disorders and schizophrenia spectrum. Vestnik Soveta molodykh uchenykh i spetsialistov Chelyabinskoi oblasti. 2016;3(13):2:62-66. (In Russ.).
  13. Delieu JM, Badawoud M, Williams MA, Horobin RW, Duguid JK. Antipsychotic drugs result in the formation of immature neutrophil leucocytes in schizophrenic patients. Journal of psychopharmacology. 2001;15(3):191-194. https://doi.org/10.1177/026988110101500306
  14. Stock AJ, Kasus-Jacobi A, Pereira HA. The role of neutrophil granule proteins in neuroinflammation and Alzheimer’s disease. Journal of neuroinflammation. 2018;15:240. https://doi.org/10.1186/s12974-018-1284-4
  15. Scali C, Prosperi C, Bracco L, Piccini C, Baronti R, Ginestroni A, Sorbi S, Pepeu G, Casamenti F. Neutrophils CD11b and fibroblasts PGE(2) are elevated in Alzheimer’s disease. Neurobiology of aging. 2002;23:523-530.
  16. Le Page A, Dupuis G, Frost EH, Larbi A, Pawelec G, Witkowski JM, Fulop T. Role of the peripheral innate immune system in the development of Alzheimer’s disease. Experimental gerontology. 2018;107:59-66. https://doi.org/10.3233/JAD-170124
  17. Dong Y, Lagarde J, Xicota L, Corne H, Chantran Y, Chaigneau T, Crestani B, Bottlaender M, Potier MC, Aucouturier P, Dorothee G, Sarazin M, Elbim C. Neutrophil hyperactivation correlates with Alzheimer’s disease progression. Annals of neurology. 2018;83:387-405. https://doi.org/10.1002/ana.25159
  18. Obraztsov IV, Godkov MA, Polimova AM, Dyomin EM, Proskurnina EV, Vladimirov YuA. An evaluation of neutrophil function in whole blood samples with two-step stimulation: a new approach to the chemiluminescence analysis. Rossijskij immunologicheskij zhurnal. 2015;9(18):4:418-425. (In Russ.).
  19. Obraztsov IV, Sukhina MA, Frolov SA, Rogovets MI, Ryabov AYu, Proskurnina EV. Neutrophil surface phenotype and oxygen metabolism alteration during priming. Tekhnologii zhivykh system. 2018;3:50-59. (In Russ.).
  20. Obraztsov IV, Godkov MA, Kulabukhov VV, Vladimirova GA, Izmailov DY, Proskurnina EV. Functional Activity of Neutrophils in Burn Sepsis. Obshchaya reanimatologiya. 2017;13(2):40-51. (In Russ.). https://doi.org/10.15360/1813-9779-2017-2-40-51
  21. Das I. Effects of neuroleptic drugs on polyamine synthesis in human neutrophils in vitro. Biochemical Society transactions. 1994;22:185S. https://doi.org/10.1042/bst022185s
  22. Chen ML, Wu S, Tsai TC, Wang LK, Tsai FM. Regulation of neutrophil phagocytosis of Escherichia coli by antipsychotic drugs. International immunopharmacology. 2014;23:550-557. https://doi.org/10.1016/j.intimp.2014.09.030
  23. Capannolo M, Fasciani I, Romeo S, Aloisi G, Rossi M, Bellio P, Celenza G, Cinque B, Cifone MG, Scarselli M, Maggio R. The atypical antipsychotic clozapine selectively inhibits interleukin 8 (IL-8)-induced neutrophil chemotaxis. European neuropsychopharmacology: the journal of the European College of Neuropsychopharmacology. 2015;25:413-424. https://doi.org/10.1016/j.euroneuro.2014.12.002

Close metadata

Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.