Neurophysiological characteristics of juvenile schizophrenia patients examined at the very remote follow up stage

Lebedeva I.S.; Golubev S.A.; Klochkova I.V.; Kaleda V.G.

doi:https://doi.org/10.17116/jnevro202012003134

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Abstract:

Objective. To determine neurophysiological characteristics of patients with long-term follow up (>20 years) and to find correlations between neurophysiological parameters and clinical features of schizophrenia. Material and methods. The patients were divided into three groups: with predomination of personality changes (group 1, n=17), with negative disorders (group 2, n=23) and with positive and negative disorders (group 3, n=40). A psychopathological method and electroencephalography with evoked potentials testing were used. Results and conclusion. In group 3, the statistically significant higher frequencies of theta-rhythm and lower of alpha-rhythm were found. Also, theta frequency correlated with PANSS positive scores. The significant intergroup differences by auditory oddball P300 were lacked. The findings are discussed in view of the hypothesis of theta-rhythm as a marker of hippocampal-prefrontal connectivity.

Keywords:

EEG

P300

schizophrenia

long-term follow-up

youthful age

outcome

Authors:

Lebedeva I.S.

Meditsinskiĭ kholding "SM-Klinika"

Golubev S.A.

Klochkova I.V.

Mental Health Research Center, Moscow, Russia

Kaleda V.G.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

SPIN RSCI: 9035-3290
Scopus AuthorID: 56765570100
ResearcherID: K-5466-2013
ORCID: 0000-0002-1209-1443

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References:

Livanov MN. EEG rhythms and their functional meaning. ZHVND. 1984;34:4:613-626. (In Russ.).
Inouye T, Shinosaki K, Yagasaki A, Shimizu A. Spatial distribution of generation of alpha activity. EEG Clin Neurophysiol. 1986;63:353-360. https://doi.org/10.1016/0013-4694(86)90020-9
Daniel D, Schacter R. EEG theta waves and psychological phenomena: a review and analysis. Biol Psychol. 1977;5(1):47-82. https://doi.org/10.1016/0301-0511(77)90028-x
Arnolds DE, Lopes da Silva FH, Aitink JW, Kamp A, Boeijinga P. The spectral properties of hippocampal EEG related to behaviour in man. EEGClin Neurophysiol. 1980;50(3-4):324-328. https://doi.org/10.1016/0013-4694(80)90160-1
Ray W, Cole H. EEG alpha activity reflects attentional demands and beta activity reflects emotional and cognitive processes. Science. 1985;228:4700:750-752. https://doi.org/10.1126/science.3992243
Moskalenko IV. An experimental study of fine EEG spectrum structure in alpha rhythm band. Psihofiziologicheskie Zakonomernosti Vospriyatiya i Pamyati. 1985. (In Russ.).
Mizuki Y. Frontal lobe: mental functions and EEG. Amer J EEG Technol. 1987;27(2):91-101. https://doi.org/10.1080/00029238.1987.11080219
Bosel R, Mecklinger A, Stolpe R. Changes in spontaneous EEG activity indicate a special kind of information processing in concept learning. Biol Psychol. 1990;31:257-269. https://doi.org/10.1016/0301-0511(90)90038-x
Morstyn R, Duffy F, McCarley R. Altered topography of EEG spectral content in schizophrenia. EEG Clin Neuroph. 1983;56(4):263-271. https://doi.org/10.1016/0013-4694(83)90251-1
Morihisa J. Computeized topographic mapping of electrophysiologic data in psychiatry. Psychiat Ann. 1985;15(4):240-253. https://doi.org/10.3928/0048-5713-19850401-10
Miyauchi T, Tanaka K, Hagino H, Miura T, Kishimoto H, Matsushita M. Computerized EEG in schizophrenic patients. Biol Psychiat. 1990;26:6:488-494. https://doi.org/10.1016/0006-3223(90)90482-h
Karson C, Coppola R, Morhisa J. Computed EEG activity mapping in schizophrenia. The resting state reconsidered. Arch Gen Psychiatry. 1987;44(6):514-517. https://doi.org/10.1001/archpsyc.1987.01800180027004
Etevenon P, Peron-Magnan P, Rioux P, Pidoux P, Bisserbe JC, Verdeaux G, Deniker P. Schizophrenia assessed by computerized EEG. Adv Biol Psychiatry. 1981;6:29-34. https://doi.org/10.1159/000400068
Small J, Milstein V, Sharpley P, Klapper M, Small IF. Electroencephalographic findings in relation to diagnostic constructs in psychiatry. Biol Psychiat. 1984;19:4:471-487.
Lifshitz K, Lee Kai L, Susswein S. Long-term replicability of EEG-spectra and auditory evoked potentials in schizophrenic and normal sybjects. Neuropsychobiolog. 1987;18(4):205-211. https://doi.org/10.1159/000118419
Itil TM. Qualitative and quantitative EEG findings in schizophrenia. Schizophr Bull. 1977;3(1):61-79. https://doi.org/10.1093/schbul/3.1.61
Galderisi S, Mucci A, Mignone ML, Maj M, Kemali D. CEEG mapping in drug free schizophrenics.Differences from helathy subjects and changes induced by haloperidol treatment. Schizophr Res. 1991;6(1):15-23. https://doi.org/10.1016/0920-9964 (91)90016-k
Frodl T, Meisenzahl EM, Gallinat J, Hegerl V, Moller HJ. Markers from event-related potentioal subcomponents and reaction time for information processing dysfunction in schizophrenia. Eur Arch Psychiatry Clin Neuroscience. 1998;248(6):307-313.
Begić D, Popović-Knapić V, Grubišin J, Kosanović-Rajačić B, Filipčić I, Telarović I, Jakovljević M. Quantitative electroencephalography in schizophrenia and depression. Psychiatr Danub. 2011;23(4):355-362.
Mel’nikova TS, Sarkisyan VV, Gurovich IYa. EEG alpha rhythm chacractrisitcs in first episode of schizophrenia. Zhurnal Social’naya i Klinicheskaya Psihiatriya. 2013;23(1):40-45. (In Russ.).
Wichniak A, Okruszek Ł, Linke M, Jarkiewicz M, Jędrasik-Styła M, Ciołkiewicz A, Wierzbicka A, Jernajczyk W, Jarema M. Electroencephalographic theta activity and cognition in schizophrenia: Preliminary results. World J Biol Psychiatry. 2015;16(3):206-210. https://doi.org/10.3109/15622975.2014.966145
Kim JW, Lee YS, Han DH, Min KJ, Lee J, Lee K. Diagnostic utility of quantitative EEG in un-medicated schizophrenia. Neurosci Lett. 2015;589:126-131. https://doi.org/10.1016/j.neulet.2014.12.064
Narayanan B, O’Neil K, Berwise C, Stevens MC, Calhoun VD, Clementz BA, Tamminga CA, Sweeney JA, Keshavan MS, Pearlson GD. Resting state electroencephalogram oscillatory abnormalities in schizophrenia and psychotic bipolar patients and their relatives from the bipolar and schizophrenia network on intermediate phenotypes study. Biol Psychiatry. 2014;76(6):456-465. https://doi.org/10.1016/j.biopsych.2013.12.008
Strelec VB, Novotockij-Vlasov VYu, Garah ZhV, Zheligovskij VA, Kaplan AYa. Multiparametric combinatoric analysis of EEG rhythms in norm and schizophrenia. ZHVND. 2007;57(6):684-691. (In Russ.).
Mathalon DH, Ford JM, Pfefferbaum A. Trait and state aspects of P300 amplitude reduction in schizophrenia: a retrospective longitudinal study. Biological Psychiatry. 2000;47(5):434-449. https://doi.org/10.1016/s0006-3223(99)00277-2
Sutton S, Braren M, Zubin J, John ER. Evoked-potential correlates of stimulus uncertainty. Science. 1965;150:187-1188. https://doi.org/10.1126/science.150.3700.1187
Donchin E, Coles M. Is the P300 component a manifestation of context updating? Behavioural Brain Science. 1988;11:357-374.
Ivanickij AM, Strelec VB, Korsakov IA. Information Brain Processes and Mental Activity. M.: Nauka; 1984. (In Russ.).
Strandburg R, Marsh J, Brown W, Asarnow R, Guthrie D, Higa J. Event-related potential correlates of impaired attention in schizophrenic children. Biological Psychiatry. 1990;27:1103-1115. https://doi.org/10.1016/0006-3223(90)90047-6
Polich J. P300 in clinical application. In: Niedermeyer E., Lopes da Silva F. Electroencephalography. Basic principles, clinical applications, and related fields. 4th edition, Williams & Wilkins, A Waverly Company. 1999.
Ford J, White P, Csernansky G, Faustman V, Roth WT, Pfefferbaum A. ERPs in schizophrenia: effects of medication. Biological Psychiatry. 1994;36:153-170. https://doi.org/10.1016/0006-3223(94)91221-1
Bramon E, Rabe-Hesketh S, Sham P, Murray R, Frangou S. Meta-analysis of the P50 and P300 waveforms in schizophrenia. Schizophr Res. 2004;70(2-3):315-329. https://doi.org/10.1016/j.schres.2004.01.004
Demiralp T, Üçok A, Devrim M, Isoglu-Alkaç U, Tecer A, Polich J. N2 and P3 components of event-related potential in first-episode schizophrenic patients: scalp topography, medication, and latency effects. Psychiatry Res. 2002;111(2-3):167-179. https://doi.org/10.1016/s0165-1781(02)00133-6
Hirayasu Y, Asato N, Ohta H, Hokama H, Arakaki H, Ogura C. Abnormalities of auditory event-related potentials in shcizophrenia prior to treatment. Biological Psychiatry. 1998;43:244-253. https://doi.org/10.1016/s0006-3223(97)00275-8
Ogura C, Nageishi Y, Matsubayashi M, Omuta F, Kishimoto A, Shimokochi M. Abnormalities in event-related potenitials: N100, P200, P300 and slow waves in schizophrenia. Jap J Psychiat Neurol. 1991;45:57-65. https://doi.org/10.1111/j.1440-1819.1991.tb00506.x
Kostandov EA, Zaharova NN, Reshchikova TN, Chak’rov VE. An impairment of information selection in patients with schizophrenia. Zhurnal Nevrologii i Psihiatrii im. S.S. Korsakova. 1993;93:55-58. (In Russ.).
Lebedeva IS, Orlova VA, Kaleda VG, Tsutsulkovskaya MYa. P300 auditory event related potentials in schizophrenia. Zhurnal Nevrologii i Psihiatrii im. S.S. Korsakova. 2000;11:47-49. (In Russ.).
Roth W, Pffeferbaum A, Horvath T, Berger P, Kopell B. P3 reduction in auditory evoked potentials of schizophrenics. EEG Clin Neurophysiology. 1980;49:497-505. https://doi.org/10.1016/0013-4694(80)90392-2
Valkonen-Korhonen M, Purhonen M, Tarkha I, Sipilä P, Partanen J, Karhu J, Lehtonen J. Altered auditory processing in acutely psychotic never medicated first episode patients. Cognitive Brain Res. 2003;17:747-758. https://doi.org/10.1016/s0926-6410(03)00199-x
Wang J, Hirayashi Y, Hiramatsu K-I, Hokama H, Miyazato H, Ogura C. Increased rate of P300 latency prolongation with age in drug-naïve and first episode schizophrenia. Clinical Neurophysiol. 2003;114:2029-2035. https://doi.org/10.1016/s1388-2457(03)00207-4
Brown KJ, Gonsalvez CJ, Harris AW, Williams LM, Gordon E. Target and non-target ERP disturbances in first episode vs. chronic schizophrenia. Clin Neurophysiol. 2002;113(11):1754-1763. https://doi.org/10.1016/s1388-2457(02)00290-0
Ranlund S, Nottage J, Shaikh M, Dutt A, Constante M, Walshe M, Hall MH, Friston K, Murray R, Bramon E. Resting EEG in psychosis and at-risk populations — a possible endophenotype? Schizophr Res. 2014;153(1-3):96-102. https://doi.org/10.1016/j.schres.2013.12.017
Harris A, Melkonian D, Williams L, Gordon E. Dynamic spectral analysis findings in first episode and chronic schizophrenia. Int J Neurosci. 2006;116(3):223-246. https://doi.org/10.1080/00207450500402977
Strelec VB, Magomedov R, Golikova ZhV, Novotockij-Vlasov VYu. Spectral power and intracortical relationships by beta2 rhythm in norm and schizophrenia. ZHVND. 2004;54(2):229-236. (In Russ.).
Bland BH. The physiology and pharmacology of hippocampal formation theta rhythms. Prog Neurobiol. 1986;26(1):1-54.
Colgin LL. Oscillations and hippocampal-prefrontal synchrony. Curr Opin Neurobiol. 2011;21(3):467-474. https://doi.org/10.1016/j.conb.2011.04.006
Benchenane K, Tiesinga PH, Battaglia FP. Oscillations in the prefrontal cortex: a gateway to memory and attention. Curr Opin Neurobiol. 2011;21(3):475-485. https://doi.org/10.1016/j.conb.2011.01.004
Godsila B, Kissc J, Speddingd M, Jaya T. The hippocampal — prefrontal pathway: The weak link in psychiatric disorders? European Neuropsychopharmacology. 2013;23:1165-1181. https://doi.org/10.1016/j.euroneuro.2012.10.018
Pittman-Polletta B, Kocsis B, Vijayan S, Whittington M, Kopell N. Brain Rhythms Connect Impaired Inhibition to Altered Cognition in Schizophrenia. Biological Psychiatry. 2015;77:1020-1030. https://doi.org/10.1016/j.biopsych.2015.02.005
Newson JJ, Thiagarajan TC. EEG Frequency Bands in Psychiatric Disorders: A Review of Resting State Studies. Front Hum Neurosci. 2019;12:521. https://doi.org/10.3389/fnhum.2018.00521
Rommel AS, Kitsune GL, Michelini G, Hosang GM, Asherson P, McLoughlin G, Brandeis D, Kuntsi J. Commonalities in EEG Spectral Power Abnormalities Between Women With ADHD and Women With Bipolar Disorder During Rest and Cognitive Performance. Brain Topogr. 2016;29(6):856-866.
Hong L, Braxton A, Gunvant M, Thaker A. Shared Low-Frequency Oscillatory Rhythm Abnormality in Resting and Sensory Gating in Schizophrenia. Clinical Neurophysiology. 2011;123(2):285-292. https://doi.org/10.1016/j.clinph.2011.07.025
Gross A, Joutsiniemi SL, Rimon R, Appelberg B. Clozapine-induced QEEG changes correlate with clinical response in schizophrenic patients: a prospective, longitudinal study. Pharmacopsychiatry. 2004;37(3):119-122. https://doi.org/10.1055/s-2004-818989
Bochkarev VK, Kirenskaya AV, Tkachenko AA, Samylkin DV, Novotockij-Vlasov VYu, Kovaleva ME. Frequency and spatial characteristics of EEG in patients with paranoid schizophrenia — a dependence on the magnitude of positive and negative symptoms. ZHVND. 2015;115(1):66-74. (In Russ.). https://doi.org/10.17116/jnevro20151151166-74
Kuhn S, Musso F, Mobascher A, Warbrick T, Winterer G, Gallinat J. Hippocampal subfields predict positive symptoms in schizophrenia: First evidence from brain morphometry. Transl Psychiatry. 2012;2(6):e127. https://doi.org/10.1038/tp.2012.51
Sigurdsson T, Duvarci S. Hippocampal-Prefrontal Interactions in Cognition, Behavior and Psychiatric Disease. Front Syst Neurosci. 2016;9:190. https://doi.org/10.3389/fnsys.2015.00190
Mori Y, Kurosu S, Hiroyama Y, Niwa S. Prolongation of P300 latency is associated with the duration of illness in male schizophrenia patients. Psychiatry Clin Neurosci. 2007;61(5):471-478. https://doi.org/10.1111/j.1440-1819.2007.01695.x
Jackson A, Seneviratne U. EEG changes in patients on antipsychotic therapy: A systematic review. Epilepsy Behav. 2019;95:1-9. https://doi.org/10.1016/j.yebeh.2019.02.005
Korostenskaja M, Kähkönen S. What do ERPs and ERFs reveal about the effect of antipsychotic treatment on cognition in schizophrenia? Curr Pharm Des. 2009;15(22):2573-2593. https://doi.org/10.2174/138161209788957474