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Samartsev I.N.
Kafedra nervnykh bolezneĭ Voenno-meditsinskoĭ akademii im. S.M. Kirova, Sankt-Peterburg
Zhivolupov S.A.
Kafedra nervnykh bolezneĭ Voenno-meditsinskoĭ akademii im. S.M. Kirova, Sankt-Peterburg
Nazhmudinov R.Z.
Elizaveta Hospital, St. Petersburg, Russia
Identification of non-steroidal anti-inflammatory drugs as a necessity basis of effectiveness and risk correlation conception
Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(12): 124‑131
Read: 22047 times
To cite this article:
Samartsev IN, Zhivolupov SA, Nazhmudinov RZ. Identification of non-steroidal anti-inflammatory drugs as a necessity basis of effectiveness and risk correlation conception. S.S. Korsakov Journal of Neurology and Psychiatry.
2019;119(12):124‑131. (In Russ.)
https://doi.org/10.17116/jnevro2019119121124
Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used for treatment of pain, fever and inflammatory diseases. However, along with a high rate of efficacy, NSAIDs have been associated with an increased risk of gastrointestinal and cardiovascular complications related to the inhibition of the enzymes cyclooxygenase 1 and 2. The review addresses contemporary mechanisms of NSAID’s side-effects and analyzes clinical trials of the efficacy and tolerability of aceclofenac, which is the most frequently prescribed NSAID, as in its traditional release form (100 mg 2 times a day) as well as in the controlled-release (200 mg a day) form.
Authors:
Samartsev I.N.
Kafedra nervnykh bolezneĭ Voenno-meditsinskoĭ akademii im. S.M. Kirova, Sankt-Peterburg
Zhivolupov S.A.
Kafedra nervnykh bolezneĭ Voenno-meditsinskoĭ akademii im. S.M. Kirova, Sankt-Peterburg
Nazhmudinov R.Z.
Elizaveta Hospital, St. Petersburg, Russia
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