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Prokhorova T.A.

Boksha I.S.

Research Centre of Mental Health

Savushkina O.K.

Tereshkina E.B.

Burbaeva G.Sh.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

α-Klotho protein in neurodegenerative and mental diseases

Authors:

Prokhorova T.A., Boksha I.S., Savushkina O.K., Tereshkina E.B., Burbaeva G.Sh.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(1): 80‑88

DOI: 10.17116/jnevro201911901180

Read: 7857 times

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Table of contents

Α-KLOTHO PROTEIN IN NEURODEGENERATIVE AND MENTAL DISEASES
Α-KLOTHO PROTEIN IN NEURODEGENERATIVE AND MENTAL DISEASES

To cite this article:

Prokhorova TA, Boksha IS, Savushkina OK, Tereshkina EB, Burbaeva GSh. α-Klotho protein in neurodegenerative and mental diseases. S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(1):80‑88. (In Russ.)
https://doi.org/10.17116/jnevro201911901180

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
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Abstract:

The review aims to attract attention of psychiatrists and neurologists to a role of α-Klotho protein in biochemical mechanisms that counteract pathogenic processes of neurodegenerative and psychiatric diseases and to possible therapeutic potential of the protein. Basing on the analysis of contemporary literature, the authors summarized the results of model experiments and a few clinical trials (in psychiatry and neurology) indicating the role of α-Klotho protein in the brain processes of neurogenesis, dendrite growth, myelination (oligodendroglia differentiation and activity), regulation of antioxidant system, and synthesis of glutamate neurotransmitter system components, regulation of the activity and synthesis of ion channel protein components and membrane transporters, synaptic plasticity. It is concluded that α-Klotho protein can be used for therapeutic purposes in diseases associated with pathological brain aging, and/or in diseases associated with insufficient synthesis of this protein.

Keywords:

klotho protein
neurodegenerative diseases
mental illness
cognitive functioning
pathological brain aging

Authors:

Prokhorova T.A.

Boksha I.S.

Research Centre of Mental Health

Savushkina O.K.

Tereshkina E.B.

Burbaeva G.Sh.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Close metadata

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