The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Kovalevа E.V.

Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk, Russia

Doronin B.M.

Novosibirskiĭ gosudarstvennyĭ meditsinskiĭ universitet

Morozov V.V.

The Center of New Medical Technologies Institute of Chemical Biology and Fundamental Medicine, The Russian Academy of Sciences, Siberian Branch Novosibirsk, Russia

Seriapina Iu.V.

Institut khimicheskoĭ biologii i fundamental'noĭ meditsiny SO RAN, Novosibirsk

Markova S.G.

Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk

Correlation of the genetic profile and features of the rehabilitation after ischemic stroke

Authors:

Kovalevа E.V., Doronin B.M., Morozov V.V., Seriapina Iu.V., Markova S.G.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(9): 22‑27

DOI: 10.17116/jnevro201811809122

Views: 956

Downloaded: 14

Download PDF (RU)
Contact the author
Table of contents

To cite this article:

Kovalevа EV, Doronin BM, Morozov VV, Seriapina IuV, Markova SG. Correlation of the genetic profile and features of the rehabilitation after ischemic stroke. S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(9):22‑27. (In Russ.)
https://doi.org/10.17116/jnevro201811809122

 
МСФ на ЯМ
Close metadata
Recommended articles:
Features of apha­sic diso­rders in patients with acute cere­brovascular diso­rder in the posterior cere­bral artery basin. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(3-2):18-22
The rela­tionship between the deve­lopment of post-stroke cognitive impairment and changes in the coagulation component of hemo­stasis. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(3-2):23-29
The multidirectional effe­cts of thro­mbin and the possibility of their control in neurology. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(3-2):42-48
Comparative characteristics of the effi­cacy and safety of the original alte­plase and its complete biosimilar in the treatment of ischemic stroke in real clinical practice. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(3-2):49-54
Effi­cacy of Mexi­dol in combination with cere­bral reva­scularization in the treatment of ischemic stroke. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(3-2):67-74
The secretome of mese­nchymal stro­mal cells as a new hope in the treatment of acute brain tissue inju­ries. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(3-2):83-91
Characteristics of lipid pero­xidation processes and factors of the antioxidant defe­nse system in chro­nic rhinitis. Russian Bulletin of Otorhinolaryngology. 2024;(1):16-20
Hemo­dynamics and repe­rfusion in acute ischemic stroke: friends or foes?. Russian Journal of Anesthesiology and Reanimatology. 2024;(2):91-96
Inte­rnational Classification of Health Inte­rventions of World Health Orga­nization as the basis for a new nome­nclature of medi­cal reha­bilitation services. Problems of Balneology, Physiotherapy and Exercise Therapy. 2024;(2):5-11
Analysis of stroke inci­dence seasonal changes in Bishkek. Russian Journal of Preventive Medi­cine. 2024;(4):89-96

Objective. To examine an effect of polymorphisms of lipid peroxidation system genes on the risk of ischemic stroke as well as the prognosis of disease outcome after rehabilitation measures. Material and methods. Seven hundred and forty-six patients with ischemic stroke and 500 patients of the control group were genotyped for 6 polymorphisms of lipid peroxidation system genes: HIF1a C1772T, ApoE Σ2/Σ3/Σ4, MnSOD C47T, GPX-1 C599T, BDNF G196T, p22phox C242T. Results and conclusion. The HIF1a C1772T polymorphism was a significant risk factor for the development of ischemic stroke with the odds ratio 1.702 (p<0.05). For GPX-1 C599T and BDNF G196T polymorphisms, a trend towards a higher frequency of heterozygous genotypes was shown in patients with the negative dynamics of neurological status. The results suggest the influence of genetic variants not only on the risk of stroke but also on treatment and rehabilitation outcomes.

Keywords:

ischemic stroke
risk factor
peroxidation
polymorphism
HIF1a
medical rehabilitation

Authors:

Kovalevа E.V.

Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk, Russia

Doronin B.M.

Novosibirskiĭ gosudarstvennyĭ meditsinskiĭ universitet

Morozov V.V.

The Center of New Medical Technologies Institute of Chemical Biology and Fundamental Medicine, The Russian Academy of Sciences, Siberian Branch Novosibirsk, Russia

Seriapina Iu.V.

Institut khimicheskoĭ biologii i fundamental'noĭ meditsiny SO RAN, Novosibirsk

Markova S.G.

Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk

List of references:

  1. Titov BV, Matveeva NA, Martynov MYu, Favorova OO. Ischemic stroke as a complex polygenic disease. Molekulyarnaya biologiya. 2015;49(2):224. (In Russ.) https://doi.org/10.7868/S0026898415020135
  2. Hachiya T, Kamatani Y, Takahashi A, Hata J, Furukawa R, Shiwa Y, Yamaji T, Hara M, Tanno K, Ohmomo H, Ono K, Takashima N, Matsuda K, Wakai K, Sawada N, Iwasaki M, Yamagishi K, Ago T, Ninomiya T, Fukushima A, Hozawa A, Minegishi N, Satoh M, Endo R, Sasaki M, Sakata K, Kobayashi S, Ogasawara K, Nakamura M, Hitomi J, Kita Y, Tanaka K, Iso H, Kitazono T, Kubo M, Tanaka H, Tsugane S, Kiyohara Y, Yamamoto M, Sobue K, Shimizu A. Genetic Predisposition to Ischemic Stroke: A Polygenic Risk Score. Stroke. 2017;48(2):253-258. https://doi.org/10.1161/STROKEAHA.116.014506
  3. Parfenov MG, Titov BV, Sudomoina MA, Martynov MYu, Favorov AV, Ochs MF, Gusev EI, Favorova OO. Complex analysis of genetic predisposition to ischemic stroke in Russians. Molekulyarnaya biologiya. 2009;43(5):937-945. (In Russ.)
  4. Titov BV, Barsova RM, Martynov MYu, Nikonova AA, Favorov AV, Gusev EI, Favorova OO. Polymorphic variants of genes encoding interleukin-6 and fibrinogen, the risk of ischemic stroke and fibrinogen levels. Molekulyarnaya biologiya. 2012;46(1):93-102. (In Russ.)
  5. Bushueva OYu, Stetskaya TA, Polonikov AV, Ivanov VP. Connection of polymorphism 640A> G of CYBA gene with risk of development of ischemic stroke in Russians in Central Russia. Zhurnal nevrologii i psikhiatrii im. C.C. Korsakova. 2015;115(9-2):38-41. (In Russ.) https://doi.org/10.17116/jnevro20151159238-41
  6. Butikov VN, Zaslavsky AS, Penina GO. Ischemic stroke in residents of the European North: analysis of risk factors. Arterial’naya gipertenziya. 2010;16(4):373-377. (In Russ.)
  7. Titov BV, Matveeva NA, Martynov MYu, Favorova OO. Multilocus analysis of the association of polymorphic variants of the genes of the inflammatory system with ischemic stroke in Russians. Molekulyarnaya biologiya. 2016;50(4):674-684. (In Russ.) https://doi.org/10.7868/S0026898416040145
  8. Qu Z, Su F, Zhu Y, Zhang S. Zhao H, Li Y, Qiao Z, Wang H. A tagging ALOX5AP polymorphism and risk of ischemic stroke in a northeastern Chinese Han population. Int J Clin Exp Med. 2015;8(11):21343-21350. eCollection. 2015. PMID: 26885075. PMCID: PMC4723920.
  9. Kumar A, Misra S, Kumar P, Sagar R, Prasad K. Association between Beta-Fibrinogen C148T Gene Polymorphism and Risk of Ischemic Stroke in a North Indian Population: A Case-Control Study. Pulse (Basel). 2017;4(4):165-171. https://doi.org/10.1159/000449361
  10. Liu X, Zhu R, Li Q, He Z. Lack of association between MCP-1 -2518A/G polymorphism and ischemic stroke: From a case-control study to an updated meta-analysis. J Neurol Sci. 2017;15(373):113-115. https://doi.org/10.1016/j.jns.2016.12.031
  11. Pereira VLC, Castellanos VCI, Sieger SFA. Polymorphisms of the lipoprotein lipase gene as genetic markers for stroke in colombian population: a case control study. Colomb Med (Cali). 2016;47(4):189-195. PMID: 28293042. PMCID: PMC5335859.
  12. Bendeck M. Targeting Pericellular Proteolysis in Vascular Disease. Circulation Research. 2002;91(10):861-862. https://doi.org/10.1161/01.res.0000043396.97121.9c
  13. Case-control studies. Tests for deviation from Hardy-Weinberg equilibrium and tests for association. Accessed November 24, 2017. https://ihg.helmholtz-muenchen.de/cgi-bin/hw/hwa1.pl
  14. Stanne TM, Tjärnlund-Wolf A, Olsson S, Jood K, Blomstrand C, Jern C. Genetic variation at the BDNF locus: evidence for association with long-term outcomeafter ischemic stroke. PLoS One. 2014;9(12):e114156. https://doi.org/10.1371/journal.pone.0114156
  15. Strambovskaya NN. Prognostic role of polymorphic variants of candidate genes in patients with ischemic stroke in Transbaikalia. Fundamental’nye issledovaniya. 2015;1(1):140-144. (In Russ.)

Close metadata

Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.