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Kovalevа E.V.

Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk, Russia

Doronin B.M.

Novosibirskiĭ gosudarstvennyĭ meditsinskiĭ universitet

Morozov V.V.

The Center of New Medical Technologies Institute of Chemical Biology and Fundamental Medicine, The Russian Academy of Sciences, Siberian Branch Novosibirsk, Russia

Seriapina Iu.V.

Institut khimicheskoĭ biologii i fundamental'noĭ meditsiny SO RAN, Novosibirsk

Markova S.G.

Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk

Correlation of the genetic profile and features of the rehabilitation after ischemic stroke

Authors:

Kovalevа E.V., Doronin B.M., Morozov V.V., Seriapina Iu.V., Markova S.G.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(9): 22‑27

DOI: 10.17116/jnevro201811809122

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Table of contents

CORRELATION OF THE GENETIC PROFILE AND FEATURES OF THE REHABILITATION AFTER ISCHEMIC STROKE
CORRELATION OF THE GENETIC PROFILE AND FEATURES OF THE REHABILITATION AFTER ISCHEMIC STROKE

To cite this article:

Kovalevа EV, Doronin BM, Morozov VV, Seriapina IuV, Markova SG. Correlation of the genetic profile and features of the rehabilitation after ischemic stroke. S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(9):22‑27. (In Russ.)
https://doi.org/10.17116/jnevro201811809122

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
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Abstract:

Objective. To examine an effect of polymorphisms of lipid peroxidation system genes on the risk of ischemic stroke as well as the prognosis of disease outcome after rehabilitation measures. Material and methods. Seven hundred and forty-six patients with ischemic stroke and 500 patients of the control group were genotyped for 6 polymorphisms of lipid peroxidation system genes: HIF1a C1772T, ApoE Σ2/Σ3/Σ4, MnSOD C47T, GPX-1 C599T, BDNF G196T, p22phox C242T. Results and conclusion. The HIF1a C1772T polymorphism was a significant risk factor for the development of ischemic stroke with the odds ratio 1.702 (p<0.05). For GPX-1 C599T and BDNF G196T polymorphisms, a trend towards a higher frequency of heterozygous genotypes was shown in patients with the negative dynamics of neurological status. The results suggest the influence of genetic variants not only on the risk of stroke but also on treatment and rehabilitation outcomes.

Keywords:

ischemic stroke
risk factor
peroxidation
polymorphism
HIF1a
medical rehabilitation

Authors:

Kovalevа E.V.

Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk, Russia

Doronin B.M.

Novosibirskiĭ gosudarstvennyĭ meditsinskiĭ universitet

Morozov V.V.

The Center of New Medical Technologies Institute of Chemical Biology and Fundamental Medicine, The Russian Academy of Sciences, Siberian Branch Novosibirsk, Russia

Seriapina Iu.V.

Institut khimicheskoĭ biologii i fundamental'noĭ meditsiny SO RAN, Novosibirsk

Markova S.G.

Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk

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References:

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