OBJECTIVE

Define the associations of inflammation biochemical markers content with hostility, social gradient, behavioral characteristics in persons of 25—44 age group in Novosibirsk.

MATERIAL AND METHODS

A random representative sample of persons aged 25—44 years in Novosibirsk (standard methods of «MONICA-psychosocial» WHO program, assessment of hostility on the reduced «Ho Scale; W.W. Cook & D.M. Medley, 1954» scale) in 2013—2016 was examined on the basis of the Research Institute of Internal and Preventive Medicine — branch of the Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences. The biochemical study was performed in the laboratory of clinical biochemical and hormonal investigations of therapeutic diseases.

RESULTS

Higher blood levels of interleukin-6 (IL-6) and TNF-α have been established both in men and women at a high level of hostility than at a medium level and its absence (p<0.01). The hostility ratio in persons of both sexes rises with an increase of IL-6 and TNF-α blood levels by 1 pg/ml, as well as of monocyte chemotactic protein-1 (MCP-1) by 100 pg/ml. The probability of hostility rose in model 1 with an increase of IL-6 blood level by 1 pg/ml, smoking, low social network index; in model 2 with an increase of TNF-α blood level by 1 pg/ml, smoking, low social network index, as well as in individuals of industrial worker jobs. In model 3, the odds ratio rose with an increase of MSR-1 level in blood by 100 pg/ml, smoking, low index of close contacts.

CONCLUSION

There was a higher content of IL-6 and in the blood along with a high level of hostility. The odds ratio of hostility in persons of both sexes rose with an increase in MSR-1 level. The association of hostility with higher IL-6, TNF-α, MSR-1 blood levels in case of smoking, low social network index, as well as in the presence of industrial worker jobs has been obtained in models 1, 2 and 3.