The influence of adenosine receptor ligands and hypoxic preconditioning on the metabolism of the brain tissue in the experiment

Minakina L.N.; Goldapel E.G.; Usov L.A.

doi:https://doi.org/10.17116/jnevro20181187154

Minakina L.N.

Irkutsk State Medical University, Irkutsk, Russia

Goldapel E.G.

Irkutsk Research Anti-Plague Institute, Irkutsk, Russia

Usov L.A.

Irkutsk State Medical University, Irkutsk, Russia

The influence of adenosine receptor ligands and hypoxic preconditioning on the metabolism of the brain tissue in the experiment

Authors:

Minakina L.N., Goldapel E.G., Usov L.A.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(7): 54‑58

DOI: 10.17116/jnevro20181187154

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To cite this article:

Minakina LN, Goldapel EG, Usov LA. The influence of adenosine receptor ligands and hypoxic preconditioning on the metabolism of the brain tissue in the experiment. S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(7):54‑58. (In Russ.)
https://doi.org/10.17116/jnevro20181187154

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)

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Abstract:

Objective. To study the influence of adenosine receptor ligands and hypoxic preconditioning on carbohydrate metabolism in global brain ischemia. Material and methods. The study included 51 outbred white male mice weighing 20-25 g. An effect of adenosine receptor ligands and hypoxic preconditioning on brain tissue metabolism, heat exchange and longevity was explored. Results and Conclusion. Adenosine, an agonist of A1 adenosine receptors, and hypoxic preconditioning exert a neuroprotective effect on brain cells. The blocker of A1 adenosine receptors aggravates metabolic disturbances in the brain and removes the protective effect of cyclopenyladenosine and ischemic preconditioning.

Keywords:

adenosine receptors

neuroprotection

ischemia

brain metabolism

lactate/pyruvate ratio

longevity

body temperature

Authors:

Minakina L.N.

Irkutsk State Medical University, Irkutsk, Russia

Goldapel E.G.

Irkutsk Research Anti-Plague Institute, Irkutsk, Russia

Usov L.A.

Irkutsk State Medical University, Irkutsk, Russia

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