The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
Phones:
+7 (495) 482-4118
+7 (495) 482-4329
  • Toll-free number for subscriptions:
    +8 800 250-18-12
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Druzhkova T.A.

Moscow Research and Clinical Center for Neuropsychiatry, Healthcare Department of Moscow, Moscow, Russia

Pochigaeva K.I.

Moscow Research and Clinical Center for Neuropsychiatry

Yakovlev A.A.

St. Petersburg City Multi-disciplinary Hospital №2

Gersamija A.G.

Moscow Research and Clinical Center for Neuropsychiatry, Moscow

Gekht A.B.

Moscow Research and Clinical Center for Neuropsychiatry of the Healthcare Department;
Pirogov Russian National Research Medical University

Gulyaeva N.V.

Institute of Higher Nervous Activity and Neurophysiology of the Russian Academy of Sciences

Effects of childhood trauma on the biochemical correlates of stress in men and women with nonpsychotic mental disorders

Authors:

Druzhkova T.A., Pochigaeva K.I., Yakovlev A.A., Gersamija A.G., Gekht A.B., Gulyaeva N.V.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(6): 10‑14

DOI: 10.17116/jnevro20181186110

Read: 1352 times

Contact the author
Table of contents

EFFECTS OF CHILDHOOD TRAUMA ON THE BIOCHEMICAL CORRELATES OF STRESS IN MEN AND WOMEN WITH NONPSYCHOTIC MENTAL DISORDERS
EFFECTS OF CHILDHOOD TRAUMA ON THE BIOCHEMICAL CORRELATES OF STRESS IN MEN AND WOMEN WITH NONPSYCHOTIC MENTAL DISORDERS

To cite this article:

Druzhkova TA, Pochigaeva KI, Yakovlev AA, Gersamija AG, Gekht AB, Gulyaeva NV. Effects of childhood trauma on the biochemical correlates of stress in men and women with nonpsychotic mental disorders. S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(6):10‑14. (In Russ.)
https://doi.org/10.17116/jnevro20181186110

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Vali­dation of the Snaith—Hamilton Pleasure Scale to assess anhe­donia in patients with unipolar depression In Russia. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(7):110-121
The effect of examination stress on students’ nocturnal sleep metrics studied with custom ECG holter and acce­lerometer. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(7):122-129
Factors supporting chro­nic inflammation in mental illness. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(8):7-15
The role of neuroinflammation in the deve­lopment of seizure acti­vity and auto­nomic diso­rders in patients with epilepsy. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(8):50-58
Features of depressive diso­rders and suicidal beha­vior in multiple scle­rosis. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(9):7-13
Effe­cts of sema­glutide on mental health. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(9):28-36
Effe­ctiveness and tole­rability of agomelatine (Valdoxan) in the treatment of depression after COVID-19 (TELESFOR study). S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(9):90-98
Oxidative stress and depression in Parkinson’s disease. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(9):131-138
Basic and complex therapy of non-segmental viti­ligo with como­rbid anxiety and anxiety-depressive adju­stment diso­rders. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(10):51-58
Psychodermatological aspe­cts of psoriasis, current condition of problem. Russian Journal of Clinical Dermatology and Vene­reology. 2025;(4):403-411
Abstract:

Objective. To investigate gender differences in biochemical characteristics in patients with nonpsychotic mental disorders, and to study their association with childhood trauma. Material and methods. Women (n=308) and men (92) between 18 and 45 years of age, without serious somatic comorbidities, were examined. Laboratory evaluation included markers of hypothalamic-pituitary-adrenal axis activity (cortisol), hypothalamic-pituitary-thyroid system (TSH), proinflammatory cytokines (Il-1β and Il-6) and the brain derived neurotrophic factor (BDNF). All participants underwent psychometric testing, which included the Child Abuse and Trauma Scale (CATS), Beck and Hamilton depression scale (HAM-D) and Spielberger Anxiety Inventory (STAI). Correlations were studied between the biochemical parameters and total CATS scores and severity of depression and anxiety in subgroups of women and men with a depressive disorder. Results and conclusion. The men and women in the total study population significantly differed by representation of the different diagnostic classes, which was reflected by differing levels of depressive and anxiety symptoms. The main finding was a correlation between the level of childhood trauma and morning serum cortisol levels in men with depressive disorder, which was absent in women.

Keywords:

stress
childhood trauma
cortisol
depression

Authors:

Druzhkova T.A.

Moscow Research and Clinical Center for Neuropsychiatry, Healthcare Department of Moscow, Moscow, Russia

Pochigaeva K.I.

Moscow Research and Clinical Center for Neuropsychiatry

Yakovlev A.A.

St. Petersburg City Multi-disciplinary Hospital №2

Gersamija A.G.

Moscow Research and Clinical Center for Neuropsychiatry, Moscow

Gekht A.B.

Moscow Research and Clinical Center for Neuropsychiatry of the Healthcare Department;
Pirogov Russian National Research Medical University

Gulyaeva N.V.

Institute of Higher Nervous Activity and Neurophysiology of the Russian Academy of Sciences

Close metadata

References:

  1. Miller AH, Maletic V, Raison CL. Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression. Biol Psychiatry. 2009;65(9):732-741. https://doi.org/10.1016/j.biopsych.2008.11.029
  2. Myers B, Carvalho-Netto E, Wick-Carlson D, Wu C, Naser S, Solomon MB, Ulrich-Lai YM, Herman JP. GABAergic Signaling within a Limbic-Hypothalamic Circuit Integrates Social and Anxiety-Like Behavior with Stress Reactivity. Neuropsychopharmacology. 2016;41(6):1530-1539. https://doi.org/10.1038/npp.2015.311
  3. Mössner R, Mikova O, Koutsilieri E, Saoud M, Ehlis AC, Muller N, Fallgatter AJ, Riederer P. Consensus paper of the WFSBP Task Force on Biological Markers: biological markers in depression. World J Biol Psychiatry. 2007;8(3):141-174. https://doi.org/10.1080/15622970701263303
  4. O’Brien SM, Scully P, Fitzgerald P, Scott LV, Dinan TG. Plasma cytokine profiles in depressed patients who fail to respond to selective serotonin reuptake inhibitor therapy. J Psychiatr Res. 2007;41(3-4):326-331. https://doi.org/10.1016/j.jpsychires.2006.05.013
  5. Pace TW, Mletzko TC, Alagbe O, Musselman DL, Nemeroff CB, Miller AH, Heim CM. Increased stress-induced inflammatory responses in male patients with major depression and increased early life stress. Am J Psychiatry. 2006;163(9):1630-1633. https://doi.org/10.1176/ajp.2006.163.9.1630
  6. Wei J, Sun G, Zhao L, Yang X, Liu X, Lin D, Li T, Ma X. Analysis of hair cortisol level in first-episodic and recurrent female patients with depression compared to healthy controls. J Affect Disord. 2015;175:299-302. https://doi.org/10.1016/j.jad.2015.01.023
  7. Pochigaeva K, Druzhkova T, Yakovlev A, Onufriev M, Grishkina M, Chepelev A, Guekht A, Gulyaeva N. Hair cortisol as a marker of hypothalamic-pituitary-adrenal Axis activity in female patients with major depressive disorder. Metab Brain Dis. 2017;32(2):577-583. https://doi.org/10.1007/s11011-017-9952-0
  8. Edwards KM, Burns VE, Ring C, Carroll D. Sex differences in the interleukin-6 response to acute psychological stress. Biol Psychol. 2006;71(3):236-239. https://doi.org/10.1016/j.biopsycho.2005.06.006
  9. Izawa S, Sugaya N, Kimura K, Ogawa N, Yamada KC, Shirotsuki K, Mikami I, Hirata K, Nagano Y, Nomura S. An increase in salivary interleukin-6 level following acute psychosocial stress and its biological correlates in healthy young adults. Biol Psychol. 2013;94(2):249-254. https://doi.org/10.1016/j.biopsycho.2013.06.006
  10. Heim C, Newport DJ, Wagner D, Wilcox MM, Miller AH, Nemeroff CB. The role of early adverse experience and adulthood stress in the prediction of neuroendocrine stress reactivity in women: a multiple regression analysis. Depress Anxiety. 2002;15(3):117-125.
  11. Kuehner C. Why is depression more common among women than among men? Lancet Psychiatry. 2017;4(2):146-158. https://doi.org/10.1016/s2215-0366(16)30263-2
  12. Gupta A, Mayer EA, Acosta JR, Hamadani K, Torgerson C, van Horn JD, Chang L, Naliboff B, Tillisch K, Labus JS. Early adverse life events are associated with altered brain network architecture in a sex- dependent manner. Neurobiol Stress. 2017;7:16-26. https://doi.org/10.1016/j.ynstr.2017.02.003
  13. Piccinelli M, Wilkinson G. Gender differences in depression. Critical review. Br J Psychiatry. 2000;177:486-492. https://doi.org/10.1192/bjp.177.6.486
  14. Grigoriadis S, Robinson GE. Gender issues in depression. Ann Clin Psychiatry. 2007;19(4):247-255. https://doi.org/10.1080/10401230701653294
  15. Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J. An inventory for measuring depression. Arch Gen Psychiatry. 1961;4:561-571. https://doi.org/10.1001/archpsyc.1961.01710120031004
  16. Tarabrina NV. Praktikum po psikhologii posttravmaticheskogo stressa. Seriya «Praktikum po psikhologii». SPb.: Piter; 2001. (In Russ.)
  17. Spielberger CD, Gorsuch RL, Lushene R, Vagg PR, Jacobs GA. Manual for the State-Trait Anxiety Inventory. Palo Alto, CA: Consulting Psychologists Press; 1983.
  18. Hanin Y, Spielberger D, Charles. The development and validation of the Russian Form of the State-Trait Anxiety Inventory. Series in Clinical & Community Psychology: Stress & Anxiety. 1983;2:15-26.
  19. Hamilton M. A rating scale for depression. J Neurol Neurosurg Psychiatry. 1960;23:56-62.
  20. Sanders B, Becker-Lausen E. The measurement of psychological maltreatment: early data on the Child Abuse and Trauma Scale. Child Abuse Negl. 1995;19(3):315-323. https://doi.org/10.1016/s0145-2134(94)00131-6
  21. Gersamia AG, Menshikova AA, Akzhigitov RG, Grishkina MN. Psychometric properties of the Child and Adolescent Trauma Screen (CATS). Rossiiskii psikhiatricheskiy zhurnal. 2015;3:21-29. (In Russ.)
  22. Holmes TH, Rahe RH. The Social Readjustment Rating Scale. J Psychosom Res. 1967;11(2):213-218. https://doi.org/10.1016/0022-3999(67)90010-4
  23. Prakticheskaya psikhodiagnostika. Metodiki i testy. Ed.: Raigorodskiy D.Ya. M.: Bakhrakh-M; 2011. (In Russ.)
  24. Lommatzsch M, Zingler D, Schuhbaeck K, Schloetcke K, Zingler C, Schuff-Werner P, Virchow JC. The impact of age, weight and gender on BDNF levels in human platelets and plasma. Neurobiol Aging. 2005;26(1):115-123. https://doi.org/10.1016/j.neurobiolaging.2004.03.002
  25. Williams MS, Ngongang CK, Ouyang P, Betoudji F, Harrer C, Wang NY, Ziegelstein RC. Gender differences in platelet brain derived neurotrophic factor in patients with cardiovascular disease and depression. J Psychiatr Res. 2016;78:72-77. https://doi.org/10.1016/j.jpsychires.2016.03.013
  26. Flory JD, Yehuda R, Grossman R, New AS, Mitropoulou V, Siever LJ. Childhood trauma and basal cortisol in people with personality disorders. Compr Psychiatry. 2009;50(1):34-37. https://doi.org/10.1016/j.comppsych.2008.05.007
  27. Suzuki A, Poon L, Papadopoulos AS, Kumari V, Cleare AJ. Long term effects of childhood trauma on cortisol stress reactivity in adulthood and relationship to the occurrence of depression. Psychoneuroendocrinology. 2014;50:289-299. https://doi.org/10.1016/j.psyneuen.2014.09.007
  28. Kreinin A, Lisson S, Nesher E, Schneider J, Bergman J, Farhat K, Farah J, Lejbkowicz F, Yadid G, Raskin L, Koman I, Pinhasov A. Blood BDNF level is gender specific in severe depression. PLoS One. 2015;10(5):0127643. https://doi.org/10.1371/journal.pone.0127643
  29. Heim C, Bradley B, Mletzko TC, Deveau TC, Musselman DL, Nemeroff CB, Ressler KJ, Binder EB. Effect of Childhood Trauma on Adult Depression and Neuroendocrine Function: Sex-Specific Moderation by CRH Receptor 1 Gene. Front Behav Neurosci. 2009;3:41. https://doi.org/10.3389/neuro.08.041.2009
  30. Ganella DE, Allen NB, Simmons JG, Schwartz O, Kim JH, Sheeber L, Whittle S. Early life stress alters pituitary growth during adolescence-a longitudinal study. Psychoneuroendocrinology. 2015;53:185-194. https://doi.org/10.1016/j.psyneuen.2015.01.005
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.