Cognitive processes in patients with different structure of anxiety disorders

Chepelyuk A.A.; Vinogradova M.G.; Kovalenok T.V.; Dorofeeva O.A.; Metlina M.V.; Neznamov G.G.

doi:https://doi.org/10.17116/jnevro2018118314-9

Chepelyuk A.A.

Zakusov Institute of Pharmacology, Moscow, Russia;
Lomonosov Moscow State University, Moscow, Russia

Vinogradova M.G.

Lomonosov Moscow State University, Moscow, Russia

Kovalenok T.V.

Zakusov Institute of Pharmacology, Moscow, Russia

Dorofeeva O.A.

Zakusov Institute of Pharmacology, Moscow, Russia

Metlina M.V.

Zakusov Institute of Pharmacology, Moscow, Russia

Neznamov G.G.

Nauchno-issledovatel'skiĭ institut farmakologii imeni V.V. Zakusova RAMN, Moskva

Cognitive processes in patients with different structure of anxiety disorders

Authors:

Chepelyuk A.A., Vinogradova M.G., Kovalenok T.V., Dorofeeva O.A., Metlina M.V., Neznamov G.G.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(3): 4‑9

DOI: 10.17116/jnevro2018118314-9

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To cite this article:

Chepelyuk AA, Vinogradova MG, Kovalenok TV, Dorofeeva OA, Metlina MV, Neznamov GG. Cognitive processes in patients with different structure of anxiety disorders. S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(3):4‑9. (In Russ.)
https://doi.org/10.17116/jnevro2018118314-9

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)

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Abstract:

Objective. To study the relationship between cognitive functions and psychopathological disturbances in anxiety disorders. Material and methods. WAIS, the modified Witkin’s Embedded figures test, a symptom scale (Yu.A. Aleksandrovsky et al. 1984) were administered to 111 patients, including 37 with generalized anxiety disorders (GAD, ICD-10 F41.1), 36 with anxiety-phobic disorders (AFD, ICD-10 F40) and 38 with anxiety-hypochondriac disorders (AHD, ICD-10 F45.2), and to 114 healthy people. Results and conclusion. A distinct trend towards an increase of cognitive impairment depending on an increase in the complicity of psychopathological picture was observed as follows: GAD — AFD — AHD. A decrease in visual-motor coordination and visual attention was found in patients with GAD. In AFD patients, besides disturbances characteristic of GAD, there was a decrease on the WAIS Vocabulary subtest. In AHD patients, there was a decrease in analytic and synthetic abilities. The heterogeneity of changes in cognitive processes and the structure of their correlations with psychopathological symptoms in anxiety disorders was revealed as follows: a decrease in some parameters of cognitive processes in anxiety disorders with mild structure, an increase in cognitive dysfunction and in a number of correlations in anxiety disorders with more complex psychopathological picture, higher scores on the WAIS Block design task.

Keywords:

cognitive impairment

WAIS

anxiety disorders

generalized anxiety disorder

anxiety-phobic disorder

anxiety-hypochondriac disorder

cognitive processes

correlations between cognitive and psychopathological parameters

Authors:

Chepelyuk A.A.

Zakusov Institute of Pharmacology, Moscow, Russia;
Lomonosov Moscow State University, Moscow, Russia

Vinogradova M.G.

Lomonosov Moscow State University, Moscow, Russia

Kovalenok T.V.

Zakusov Institute of Pharmacology, Moscow, Russia

Dorofeeva O.A.

Zakusov Institute of Pharmacology, Moscow, Russia

Metlina M.V.

Zakusov Institute of Pharmacology, Moscow, Russia

Neznamov G.G.

Nauchno-issledovatel'skiĭ institut farmakologii imeni V.V. Zakusova RAMN, Moskva

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References:

Starcevic V, Castle DJ. Stress: Concepts, Cognition, Emotion, and Behavior. Handbook of Stress, Volume 1. In: FINK G, ed. Amsterdam, Boston, Heidelberg, London, New York, Oxford, Paris, San Diego, San Francisco, Singapore, Sydney, Tokyo: Elsevier; 2016;203-211.
Baldwin DS, Hou R, Gordon R, Huneke NTM, Garner M. Pharmacotherapy in Generalized Anxiety Disorder : Novel Experimental Medicine Models and Emerging Drug Targets. CNS Drugs. 2017:4-12. https://doi.org/10.1007/s40263-017-0423-2
Bobes J, Cabarello L, Vilardaga I, Rejas J. Disability and health-related quality of life in outpatients with generalised anxiety disorder treated in psychiatric clinics: is there still room for improvement? Ann Gen Psychiatry. 2011;10(7). https://doi.org/10.1186/1744-859X-10-7
Airaksinen E, Larsson MFY. Neuropsychological functions in anxiety disorders in population-based samples: evidence of episodic memory dysfunction. J Psychiatr Res. 2005;39:207-214. https://doi.org/10.1016/j.jpsychires.2004.06.001
Chutko LS, Surushkina SYu, Yakovenko EA, Nikishena IS, Anisimova TI, Bondarchuk YuL. Cognitive disorders in patients with generalized anxiety disorder. Psikhiatria i psikhofarmakologiya im. P.B. Gannushkina. 2013;3;38-44. (In Russ.)
Gordeev SA, Posohov SI, Covrov GV, Katenko SV. Psychophysiological specific of panic attack and generalized anxiety disorder. Zhurnal Nevrologii i Psihiatrii im. S.S. Korsakova. 2013;113(5):11-14. (In Russ.)
Eseykina LI, Pluznikov IV. Attention impairment in anxiety disorders: neuropsychological approach. Psikhiatriya. 2016;70(3):55-56. (In Russ.)
Castilio EP, Campos Coy PE, Shejet FO, Duran ET, Cabrera DM. Evaluacion de function es cognitivas; atenciony memoria en pacient es contrastorno de panictle. Solud Ment. 2010;33:481-488.
Derakshan N, Smyth S, Eysenck MW. Effects of state anxiety on performance using a task-switching paradigm: An investigation of attentional control theory. Psychonomic Bulletin & Review. 2009;16(6):1112-1117. https://doi.org/10.3758/PBR.16.6.1112
Rector Kamkar NA, Cassin K, Ayearst SE, Laposa LE. Assessing excessive reassurance seeking in the anxiety disorders. J Anxiety Disord. 2011;25(7):911-917. https://doi.org/10.1016/j.janxdis.2011.05.003
Van den Heuvel OA, Veltman DJ, Groenewegen HJ, Witter MP, Merkelbach J, Cath DC, van Balkom AJLM, van Oppen P, van Dyck R. Disorder-Specific Neuroanatomical Correlates of Attentional Bias in Obsessive-compulsive Disorder, Panic Disorder, and Hypochondriasis. Arch Gen Psychiatry. 2005;62(8):922-933. https://doi.org/10.1001/archpsyc.62.8.922
Pacheco-Unguetti AP, Acosta A, Marques ELJ. Alterations of the attentional networks in patients with anxiety disorders. J Anxiety Disord. 2011;25:888-895. https://doi.org/10.1016/j.janxdis.2011.04.010
Cisler JM, Koster Ernst HW. Clinical Psychology Review Mechanisms of attentional biases towards threat in anxiety disorders: An integrative review. Clin Psychol Rev. 2010;30(2):203-216. https://doi.org/10.1016/j.cpr.2009.11.003
Ottaviani C, Watson DR, Meeten F, Makovac E, Garfinkel SN, Critchley HD. Neurobiological substrates of cognitive rigidity and autonomic inflexibitity in generalized anxiety disorder. Biol Psychol. 2016. https://doi.org/10.1016/j.biopsycho.2016.06.009
Hecker JE. (Eds). Introduction to clinical psychology: science, practice and ethics. NY. 2005;599.
Fergus Wu TA, Kevin D. Do Symptoms of Generalized Anxiety and Obsessive-Compulsive Disorder Share Cognitive Processes? Cogn Ther Res. 2010;34:168-176. https://doi.org/10.1007/s10608-009-9239-9
Pérez MAN, Delgado MMR, M, Mateos LL, Bueno N. Cognitive Control and Anxiety Disorders: Metacognitive Beliefs and Strategies of Control Thought in GAD and OCD. Clinica y Salud. 2010;21;159-167. https://doi.org/10.5093/cl2010v21n2a5
Allison J. Cognitive vulnerability to anxiety: A review and integrative model. Clinical Psychology Review. 2009;29:459-470.
Starcevic V, Berle D. Cognitive specificity of anxiety disorders: a review of selected key constructs. Depress Anxiety. 2006;23:51-61. https://doi.org/10.1002/da.20145
Aleksandrovskii YuA, Rudenko GM, Neznamov GG. Unifitsirovannaya sistema otsenki kliniko-farmakologicheskogo deistviya psikhotropnykh preparatov u bol’nykh s pogranichnymi nervno-psikhicheskimi rasstroistvami. M. 1984. (In Russ.)
Filimonenko YuI, Timofeev VI. Test Vekslera. Diagnostika urovnya razvitiya intellekta (vzroslyi variant). Metodicheskoe rukovodstvo. SPb.: Imaton; 2006. (In Russ.)
Vinogradova MG, Shabanova AA. Metodicheskie rekomendatsii k provedeniyu modifitsirovannogo testa G. Vitkina. M. 2014. (In Russ.)
Chutko LS, Surushkina SYu, Yakovenko EA, Nikishena IS, Anisimova TI, Bondarchuk YuL. Cognitive disorders in patients with generalized anxiety disorder. Psikhiatria i psikhofarmakologiya im. P.B. Gannushkina. 2013;3;38-44. (In Russ.)
Korabelnikova EA, Budic AM. Anxiety disorders: clinical and psychological features. Psikhicheskoe zdorov’e. 2011;12(67):47-54. (In Russ.)