Neurotrauma as a factor of epileptogenesis

Shishmanidi A.K.

Stavropol State Medical University, Stavropol, Russia

Karpov S.M.

Stavropol State Medical University, Stavropol, Russia

Vyshlova I.A.

Stavropol State Medical University, Stavropol, Russia

Karpov A.S.

Stavropol State Medical University, Stavropol, Russia

Bahadova E.M.

Stavropol State Medical University, Stavropol, Russia

Neurotrauma as a factor of epileptogenesis

Authors:

Shishmanidi A.K., Karpov S.M., Vyshlova I.A., Karpov A.S., Bahadova E.M.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(10): 90‑92

DOI: 10.17116/jnevro201811810190

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To cite this article:

Shishmanidi AK, Karpov SM, Vyshlova IA, Karpov AS, Bahadova EM. Neurotrauma as a factor of epileptogenesis. S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(10):90‑92. (In Russ.)
https://doi.org/10.17116/jnevro201811810190

Подписка 2025-2 (S.S. Korsakov Journal of Neurology and Psychiatry)

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The presented article deals with traumatic brain injury, which can cause convulsive seizures with the subsequent development of epilepsy, which is especially characteristic of young people. The problems of classification of posttraumatic epileptic seizures, development of their mechanisms, characteristics of diagnosis, as well as the stages of epileptogenesis leading to the development of traumatic epilepsy are considered. The variants of therapy are given in view of traumatic brain injury. It is noted that the use of electrical stimulation during individual phases of paroxysmal oscillations can be an effective method in preventing the development of homeostatic plasticity that is involved in the development of epileptogenesis.

Keywords:

epileptogenesis

traumatic brain injury

epilepsy

classification

Authors:

Shishmanidi A.K.

Stavropol State Medical University, Stavropol, Russia

Karpov S.M.

Stavropol State Medical University, Stavropol, Russia

Vyshlova I.A.

Stavropol State Medical University, Stavropol, Russia

Karpov A.S.

Stavropol State Medical University, Stavropol, Russia

Bahadova E.M.

Stavropol State Medical University, Stavropol, Russia

List of references:

Dinner D. Posttraumatic epilepsy. In: Wyllie E, editor. The treatment of epilepsy: principles and practice. Philadelphia: Lea &Fibinger. 1993.
Marcikic M, Melada A, Kovacevic R. Management of war penetrating craniocerebral injuries during the war in Croatia. Injury. 1998;29:613-618.
Salazar A, Jabbari B, Vance S, Grafman J, Amin D, Dillon J. Epilepsy after penetrating head injury. I. Clinical correlates: a report of the Vietnam Head Injury Study. Neurology. 1985;35:1406-1414.
Sokolova IV, Karpov SM. Traumatic epilepsy with brain injury. Mezhdunarodnyi Zhurnal Prikladnykh I Fundamental’nykh Issledovanii. 2012;1:44-45. (In Russ)
Lowenstein DH. Epilepsy after head injury: an overview. Epilepsia. 2009; 50(suppl 2):4-9. https://doi.org/10.1111/j.1528-1167.2008.02004.x
Asikainen I, Kaste M, Sarna S. Early and late posttraumatic seizures in traumatic brain injury rehabilitation patients: brain injury factors causing late seizures and influence of seizures on long-term outcome. Epilepsia. 1999;40:584-589.
McCrory PR, Bladin PF, Berkovic SF. Retrospective study of concussive convulsions in elite Australian rules and rugby league footballers: phenomenology, aetiology, and outcome. British Medical Journal. 1997;314:171-174.
Gupta YK, Gupta M. Post traumatic epilepsy: a review of scientific evidence. Indian J Physiol Pharmacol. 2006;50:7-16.
Haltiner AM, Temkin NR, Dikmen SS. Risk of seizure recurrence after the first late posttraumatic seizure. Arch Phys Med Rehabil. 1997;78:835-840.
Christensen J, Pedersen MG, Pedersen CB, Sidenius P, Olsen J, Vestergaard M. Long-term risk of epilepsy after traumatic brain injury in children and young adults: a population-based cohort study. Lancet. 2009;373(9669):1105-1110. https://doi.org/10.1016/S0140-6736(09)60214-2
Aarabi B, Taghipour M, Haghnegahdar A, Farokhi M, Mobley L. Prognostic factors in the occurrence of posttraumatic epilepsy after penetrating head injury suffered during military service. Neurosurg Focus. 2000;8(1):1.
Frey LC. Epidemiology of posttraumatic epilepsy: a critical review. Epilepsia. 2003;44(suppl 10):11-17.
da Silva AM, Nunes B, Vaz AR, Mendonça D. Posttraumatic epilepsy in civilians: clinical and electroencephalographic studies. Acta Neurochir Suppl (Wien). 1992;55:56-63.
Pagni CA. Posttraumatic epilepsy. Incidence and prophylaxis. Acta Neurochir Suppl (Wien). 1990;50:38-47.
Karpov SM, Gandylyan KS, Karakov KG, Azoidis I, Eliseeva E. Neurophysiological aspects of combined craniofacial trauma. European Journal of Neurology. 2016;23(2):727.
Diaz-Arrastia R, Agostini MA, Frol AB, Mickey B, Fleckenstein J, Bigio E, Van Ness PC. Neurophysiologic and neuroradiologic features of intractable epilepsy after traumatic brain injury in adults. Arch Neurol. 2000;57:1611-166.
Kumar R, Gupta RK, Rao SB, Chawla S, Husain M, Rathore RK. Magnetization transfer and T2 quantitation in normal appearing cortical gray matter and white matter adjacent to focal abnormality in patients with traumatic brain injury. Magn Reson Imaging. 2003;21:893-899.
Beghi E. Overview of studies to prevent posttraumatic epilepsy. Epilepsia. 2003;44(suppl 10):21-26.
Temkin NR, Dikmen SS, Anderson GD, Wilensky AJ, Holmes MD, Cohen W, Newell DW, Nelson P, Awan A, Winn HR. Valproate therapy for prevention of posttraumatic seizures: a randomized trial. J Neurosurg. 1999;91(4):593-600.
Temkin NR, Dikmen SS, Wilensky AJ, Keihm J, Chabal S, Winn HR. A randomized, double-blind study of phenytoin for the prevention of post-traumatic seizures. New England Journal of Medicine. 1990;323(8):497-502.
Watson NF, Barber JK, Doherty MJ, Miller JW, Temkin NR. Does glucocorticoid administration prevent late seizures after head injury? Epilepsia. 2004;45(6):690-4.
Liesemer K, Bratton SL, Zebrack CM, Brockmeyer D, Statler KD. Early post-traumatic seizures in moderate to severe pediatric traumatic brain injury: rates, risk factors, and clinical features. J Neurotrauma. 2011;28:755-762. https://doi.org/10.1089/neu.2010.1518
Tilford JM, Simpson PM, Yeh TS, Lensing S, Aitken ME, Green JW, Harr J, Fiser DH. Variation in therapy and outcome for pediatric head trauma patients. Critical Care Medicine. 2001;29(5):1056-1061.
Pearl PL, McCarter R, McGavin CL, Yu Y, Sandoval F, Trzcinski S, Atabaki SM, Tsuchida T, van den Anker J, He J, Klein P. Results of phase II levetiracetam trial following acute head injury in children at risk for posttraumatic epilepsy. Epilepsia. 2013;54:135-137. https://doi.org/10.1111/epi.12326
Arndt DH, Lerner JT, Matsumoto JH, Madikians A, Yudovin S, Valino H, McArthur DL, Wu JY, Leung M, Buxey F, Szeliga C, Van Hirtum-Das M, Sankar R, Brooks-Kayal A, Giza CC. Subclinical early posttraumatic seizures detected by continuous EEG monitoring in a consecutive pediatric cohort. Epilepsia. 2013;54(10):1780-1788. https://doi.org/10.1111/epi.12369.
Annegers JF, Grabow JD, Groover RV, Laws ER Jr, Elveback LR, Kurland LT. Seizures after head trauma: a population study. Neurology. 1980;30(7 Pt 1):683-689.
Chang BS, Lowenstein DH. Quality Standards Subcommittee of the American Academy of Neurology: Practice parameter: antiepileptic drug prophylaxis in severe traumatic brain injury: report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology. 2003;60:10.
Hoffman SN, Salin PA, Prince DA. Chronic neocortical epileptogenesis in vitro. J Neurophysiol. 1994;71:1762-1773.
Li H, Bandrowski AE, Prince DA. Cortical injury affects short-term plasticity of evoked excitatory synaptic currents. J Neurophysiol. 2005;93:146-156.
Timofeev I, Bazhenov M, Avramescu S, Nita DA. Posttraumatic epilepsy: the roles of synaptic plasticity. Neuroscientist. 2010;16(1):19-27. https://doi.org/10.1177/1073858409333545..
Salin P, Tseng GF, Hoffman S, Parada I, Prince DA. Axonal sprouting in layer V pyramidal neurons of chronically injured cerebral cortex. J Neurosci. 1995;15(12):8234-8245.

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