A search of target regions for association studies between DNA methylation and cognitive impairment in schizophrenia

Kondratyev N.V.; Alfimova M.V.; Golimbet V.E.

doi:https://doi.org/10.17116/jnevro20171178172-75

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Abstract:

Objective. To develop a strategy for the search for candidate genes and targets for epigenetic studies of cognitive impairments in patients with schizophrenia. Material and methods. A search for literature on epigenetics of schizophrenia and cognitive functions was performed. Single nucleotide polymorphisms (SNPs) that can create or abolish a site for DNA methylation or transcription factor sites were determined using a custom script. Results and conclusion. Eight candidate genes, including BDNF, COMT, RELN, SNRPN, PSMA4, FAM63B, IL-1RAP, MAD1L1, as well as 750 targets in CpG islands in the linkage regions identified in GWAS of schizophrenia and 406 targets in SNV located within transcription factor binding sites were selected.

Keywords:

schizophrenia

cognitive impairment

DNA methylation

CpG-SNV

transcription factors

Authors:

Kondratyev N.V.

Mental Health Research Center, Moscow, Russia

Alfimova M.V.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN

Golimbet V.E.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

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References:

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