Divasa in the treatment and prevention of cerebrovascular diseases

Close metadata

Recommended articles:

Cerebrolysin as an early add-on to reperfusion therapy: heterogeneous treatment effect analysis in ischemic stroke patients with varying risk of hemorrhagic transformation. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(3-2):55-66

Efficacy of Mexidol in combination with cerebral revascularization in the treatment of ischemic stroke. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(3-2):67-74

Neurometabolic therapy of mild cognitive impairment in patients with chronic cerebral ischemia. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(3):42-51

Validation of screening method based on EEG analysis for the risk assessment of psychiatric and behavioral disorders: a pilot study. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(3):88-96

Results of a pilot study of the structure and evaluation of the therapy for chronic sleep disorders in comorbid patients with chronic cerebral ischemia. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(4):118-126

Cognitive impairment in cerebrovascular diseases. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(4-2):12-16

Algorithms for the diagnosis and treatment of cognitive impairment and dysphagia in stroke patients. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(4-2):100-107

Posttraumatic stress disorder clinical guidelines and treatment standards: focus on the symptoms of the psychophysiological arousal. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(5):58-68

Asthenia in young patients and possibilities for its correction. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(5):133-137

Surgical treatment of congenital and acquired internal carotid artery tortuosity in patients with ocular ischemic syndrome. Russian Journal of Cardiology and Cardiovascular Surgery. 2024;(3):272-278

Disturbances of hemorheology, hemostasis and fibrinolysis play an important role in the pathogenesis and pathophysiology of chronic cerebral ischemia. Physiological functioning of the endothelium is disturbed under the action of damaging factors. Divaza is created on the basis of release-active antibodies to S100b protein and antibodies to endothelial NO-synthase. The efficacy of divaza in the treatment of chronic cerebral ischemia and related diseases (cognitive impairment, anxiety) was demonstrated. A normalizing effect of divaza in the dose of 2 tablets 3 times daily between meals during 12 weeks on endothelial function is shown.

Keywords:

chronic cerebral ischemia

stroke

anxiety

divaza

brain specific protein S100

List of references:

Shchepankevich LA. Ischemic stroke in patients with diabet type 2: blood and vascular wall [abstract of dissertation]. Novosibirsk. 2014. On 01.06.17 (In Russ.) http://vak.ed.gov.ru/dis-details?xPARAM=172987
Fateeva VV, Vorob’eva OV. Cerebral markers of endothelial dysfunction in chronic brain ischemia. Zh Nevrol Psikhiatr Im. S.S. Korsakova. 2017;117(4):106-110. (In Russ.) https://doi.org/10.17116/jnevro201711741106-110
Fateeva VV, Vorob’eva OV, Glazunov AB. Endothelial dysfunction is a pharmacological target for therapy of affective disorders in patients with cardiovascular diseases. Consilium Medicum. 2017;117:19(2.1):84-88. (In Russ.)
Shavlovskaya OA. Clinical efficacy of neuropeptides in cerebrovascular pathology. Zh Nevrol Psikhiatr Im. S.S. Korsakova. 2016;116(8):88-93. (In Russ.) https://doi.org/10.17116/jnevro20161168188-93
Skoromets AA, Stakhovskaya LV, Belkin AA, Shekhovtsova KV, Kerbikov OB, Burenchev DV, Gavrilova OV, Skvortsova VI. New possibilities of neuroprotection in the treatment of ischemic stroke. Zh Nevrol Psikhiatr Im. S.S. Korsakova. 2008;22(108):32-38. PMID: 19431244. (In Russ.)
Trailin AV, Levada OA. Protein S100B: neuroscience, the importance in neurological and psychiatric disease. International neurological journal. 2009;3:1(23):166-172. (In Russ.)
Lasič E, Galland F, Vardjan N, Šribar J, Križaj I, Leite MC, Zorec R, Stenovec M. Time-dependent uptake and trafficking of vesicles capturing extracellular S100B in cultured rat astrocytes. J Neurochem. 2016;139(2): 309-323. https://doi.org/10.1111/jnc.13754
Sherstnev VV, Yurasov VV, Gruden MA, Yakovleva NE, Storozheva ZI, Proshin AT, Puzyrev AV. Biochemical markers of apoptosis in the brain of «intact» rats and after the central application of S100b protein. Neurochemistry. 2004;21(2):110-114. (In Russ.)
Sandweiss AJ, Azim A, Ibraheem K, Largent-Milnes TM, Rhee P, Vanderah TW, Joseph B. Remote ischemic conditioning preserves cognition and motor coordination in a mouse model of traumatic brain injury. J Trauma Acute Care Surg. 2017. https://doi.org/10.1097/TA.0000000000001626
Welch RD, Ellis M, Lewis LM, Ayaz SI, Mika VH, Millis S, Papa L. Modeling the kinetics of serum glial fibrillary acidic protein, ubiquitin carboxyl-terminal hydrolase-L1, and S100b concentrations in patients with traumatic brain injury. J Neurotrauma. 2017;34(11):1957-1971. https://doi.org/10.1089/neu.2016.4772
Liswati E, Wijaya A, Ranakusuma TAS. Biochemical markers for differential diagnosis of stroke: a biochemical markers study of S100b protein, neuron spesific enolase (NSE), myelin basic protein (MBP), and heart-type fatty acid binding protein (H-FABP). The Indonesian Biomedical Journal. 2009;1(1):68. https://doi.org/10.18585/inabj.v1i1.85
Li Y, Yu ZX, Ji MS, Yan J, Cai Y, Liu J, Yang HF, Jin ZC. A pilot study of the use of dexmedetomidine for the control of delirium by reducing the serum concentrations of brain-derived neurotrophic factor, neuron-specific enolase, and S100b in polytrauma patients. J Intensive Care Med. 2017: 885066617710643. https://doi.org/10.1177/0885066617710643
Tanaeva KK, Dugina YuL, Kachaeva EV, Epshteyn OI. Prospects of the novel combined drug divaza in the pathogenetic treatment of chronic cerebral ischemia. Zh Nevrol Psikhiatr Im. S.S. Korsakova. 2014;114(9):94-98. PMID: 25473662. (In Russ.)
Vorob’eva ОV, Fateeva VV. Divazа in the treatment of cerebrovascular disease: the mechanism of drug action and indications to its administration. Psychiatry. 2015;2:45-54. (In Russ.)
Kamchatnov PR, Vorob’eva OV, Rachin AP. Treatment of emotional and cognitive disorders in patients with chronic cerebral ischemia. Zh Nevrol Psikhiatr Im. S.S. Korsakova. 2014;114(4):52-56. PMID: 24874318. (In Russ.)
Vorob’eva OV, Kamchatnov PR, Rachin AP. Efficacy and safety of the novel neurotropic drug Divaza in combination therapy of chronic cerebral ischemia. Effective pharmacotherapy. 2014;31:42-48. (In Russ.)
Chukanova EI, Bogolepova AN, Chukanova AS. An experience of using divasa in the treatment of cerebrovascular insufficiency Zh Nevrol Psikhiatr Im. S.S. Korsakova. 2015;115(6):110-114. (In Russ.) https://doi.org/10.17116/jnevro201511561110-114
Dadasheva MN, Taranenko NYu, Agafonov BV. Innovative treatment of cerebrovascular disease in patients with variable arterial hypertension. Practical medicine. 2015;5(90):221-224. (In Russ.)
Mudrova OA, Sokolov NB, Borikov FA. The efficacy of divasa in the early recovery period of ischemic stroke. Zh Nevrol Psikhiatr Im. S.S. Korsakova. 2016;116:48-53. PMID: 27296802. (In Russ.)
Parfyonov VA, Verbitskaya SV. Secondary prevention of ischemic stroke and cognitive impairment. Medical council. 2016;11:6-12. (In Russ.) https://doi.org/10.21518/2079-701x-2016-11-18-24
Fateeva VV, Kolokolov OV, Zakharova NB, Maleina AYu, Abramova TP, Fisun AV, Kolokolova AM, Makarov NS. Disorders in sleep and cognitive functions as representations of chronic cerebral ischemia and pathogenic basis for their correction. Treating doctor. 2016;5:18-23. (In Russ.)
Fateeva VV, Shumakher GI, Vorob’eva EN, Khoreva MA, Voskanyan LR. The efficacy and safety of drug therapy divaza in patients with chronic cerebral ischemia. Zh Nevrol Psikhiatr Im. S.S. Korsakova. 2017;117(2):32-37. (In Russ.) https://doi.org/10.17116/jnevro20171172132-37

Close metadata