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Polushin A.Yu.

Gorbacheva Research Institute Oncology, Hematology and Transplantology, St. Petersburg, Russia;
Pavlov First St. Petersburg State Medical University Ministry of Health of the Russian Federation, St. Petersburg, Russia

Ianishevskiĭ S.N.

Voenno-meditsinskaia akademiia im. S.M. Kirova, Sankt-Peterburg

Maslevtsov D.V.

Pavlov First St. Petersburg State Medical University, St. Petersburg, Russia

Krivov V.O.

Pavlov First St. Petersburg State Medical University, St. Petersburg, Russia

Beskrovnaya O.V.

Pavlov First St. Petersburg State Medical University, St. Petersburg, Russia

Molchan N.S.

Pavlov First St. Petersburg State Medical University, St. Petersburg, Russia

The efficacy of prevention of postoperative cognitive dysfunction in cardiac surgeries with the use of the cerebrolysin

Authors:

Polushin A.Yu., Ianishevskiĭ S.N., Maslevtsov D.V., Krivov V.O., Beskrovnaya O.V., Molchan N.S.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2017;117(12): 37‑45

DOI: 10.17116/jnevro201711712137-45

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THE EFFICACY OF PREVENTION OF POSTOPERATIVE COGNITIVE DYSFUNCTION IN CARDIAC SURGERIES WITH THE USE OF THE CEREBROLYSIN
THE EFFICACY OF PREVENTION OF POSTOPERATIVE COGNITIVE DYSFUNCTION IN CARDIAC SURGERIES WITH THE USE OF THE CEREBROLYSIN

To cite this article:

Polushin AYu, Ianishevskiĭ SN, Maslevtsov DV, Krivov VO, Beskrovnaya OV, Molchan NS. The efficacy of prevention of postoperative cognitive dysfunction in cardiac surgeries with the use of the cerebrolysin. S.S. Korsakov Journal of Neurology and Psychiatry. 2017;117(12):37‑45. (In Russ.)
https://doi.org/10.17116/jnevro201711712137-45

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Objective. To assess the efficacy of postoperative cytoprotection with cerebrolysin in cardiac surgeries without using cardiopulmonary bypass and to analyze the changes in the blood circulation in the postoperative period in groups with- and without cerebrolysin preconditioning. Material and methods. Thirty-eight patients, who underwent coronary and mammaro-coronary bypass grafting without using cardiopulmonary bypass, were included in the study. Fifteen patients received cerebrolysin before surgery. Results and conclusion. Cerebrolysin improved cognitive test scores. Positive changes on anxiety and depression scales were observed as well. In the group of patients treated with cerebrolysin, quantitative parameters of the cerebral blood flow were in stable condition, with a slight increase on the 10th day after surgery, which may indicate increasing stress resistance of cells of the central nervous system after appropriate pharmacological protection.

Keywords:

cerebrolysin
neuroprotection
cerebral blood flow
postoperative cognitive dysfunction
preconditioning

Authors:

Polushin A.Yu.

Gorbacheva Research Institute Oncology, Hematology and Transplantology, St. Petersburg, Russia;
Pavlov First St. Petersburg State Medical University Ministry of Health of the Russian Federation, St. Petersburg, Russia

Ianishevskiĭ S.N.

Voenno-meditsinskaia akademiia im. S.M. Kirova, Sankt-Peterburg

Maslevtsov D.V.

Pavlov First St. Petersburg State Medical University, St. Petersburg, Russia

Krivov V.O.

Pavlov First St. Petersburg State Medical University, St. Petersburg, Russia

Beskrovnaya O.V.

Pavlov First St. Petersburg State Medical University, St. Petersburg, Russia

Molchan N.S.

Pavlov First St. Petersburg State Medical University, St. Petersburg, Russia

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