The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Polushin A.Yu.

Gorbacheva Research Institute Oncology, Hematology and Transplantology, St. Petersburg, Russia;
Pavlov First St. Petersburg State Medical University Ministry of Health of the Russian Federation, St. Petersburg, Russia

Ianishevskiĭ S.N.

Voenno-meditsinskaia akademiia im. S.M. Kirova, Sankt-Peterburg

Maslevtsov D.V.

Pavlov First St. Petersburg State Medical University, St. Petersburg, Russia

Krivov V.O.

Pavlov First St. Petersburg State Medical University, St. Petersburg, Russia

Beskrovnaya O.V.

Pavlov First St. Petersburg State Medical University, St. Petersburg, Russia

Molchan N.S.

Pavlov First St. Petersburg State Medical University, St. Petersburg, Russia

The efficacy of prevention of postoperative cognitive dysfunction in cardiac surgeries with the use of the cerebrolysin

Authors:

Polushin A.Yu., Ianishevskiĭ S.N., Maslevtsov D.V., Krivov V.O., Beskrovnaya O.V., Molchan N.S.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2017;117(12): 37‑45

DOI: 10.17116/jnevro201711712137-45

Read: 1593 times

Download PDF (RU)
Contact the author
Table of contents

THE EFFICACY OF PREVENTION OF POSTOPERATIVE COGNITIVE DYSFUNCTION IN CARDIAC SURGERIES WITH THE USE OF THE CEREBROLYSIN
THE EFFICACY OF PREVENTION OF POSTOPERATIVE COGNITIVE DYSFUNCTION IN CARDIAC SURGERIES WITH THE USE OF THE CEREBROLYSIN

To cite this article:

Polushin AYu, Ianishevskiĭ SN, Maslevtsov DV, Krivov VO, Beskrovnaya OV, Molchan NS. The efficacy of prevention of postoperative cognitive dysfunction in cardiac surgeries with the use of the cerebrolysin. S.S. Korsakov Journal of Neurology and Psychiatry. 2017;117(12):37‑45. (In Russ.)
https://doi.org/10.17116/jnevro201711712137-45

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Stroke: current state of the problem. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(11):7-18
Modern aspe­cts of chro­nic cere­bral ischemia pathogenetic therapy. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(12):106-113
Neurocytoprotection adva­nces in repe­rfusion therapy. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(12-2):75-88
Cere­brolysin and the opti­mal timing of anti­coagulation resu­mption in stroke: combined post hoc survival analysis of the CERE­HETIS trial. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(3-2):77-93
The known and new ideas about the mechanism of action and the spectrum of effe­cts of Mexi­dol. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(5):22-33
Therapeutic pote­ntial of quercetin and its deri­vatives against COVID-19. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(5):44-50
Cere­brolysin with repe­rfusion therapy in ischemic stroke: a prospective analysis of multimodal brain imaging data from the CERE­HETIS trial. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(6):84-98
Neurometabolic therapy with Cere­brolysin in patients with sepsis-associated ence­phalopathy. Russian Journal of Anesthesiology and Reanimatology. 2024;(6):46-54
Neuroprotective therapy for age-related macu­lar dege­neration. Russian Annals of Ophthalmology. 2024;(6):152-158
Neuroprotective therapy of glaucoma. Russian Annals of Ophthalmology. 2025;(1):83-90
Abstract:

Objective. To assess the efficacy of postoperative cytoprotection with cerebrolysin in cardiac surgeries without using cardiopulmonary bypass and to analyze the changes in the blood circulation in the postoperative period in groups with- and without cerebrolysin preconditioning. Material and methods. Thirty-eight patients, who underwent coronary and mammaro-coronary bypass grafting without using cardiopulmonary bypass, were included in the study. Fifteen patients received cerebrolysin before surgery. Results and conclusion. Cerebrolysin improved cognitive test scores. Positive changes on anxiety and depression scales were observed as well. In the group of patients treated with cerebrolysin, quantitative parameters of the cerebral blood flow were in stable condition, with a slight increase on the 10th day after surgery, which may indicate increasing stress resistance of cells of the central nervous system after appropriate pharmacological protection.

Keywords:

cerebrolysin
neuroprotection
cerebral blood flow
postoperative cognitive dysfunction
preconditioning

Authors:

Polushin A.Yu.

Gorbacheva Research Institute Oncology, Hematology and Transplantology, St. Petersburg, Russia;
Pavlov First St. Petersburg State Medical University Ministry of Health of the Russian Federation, St. Petersburg, Russia

Ianishevskiĭ S.N.

Voenno-meditsinskaia akademiia im. S.M. Kirova, Sankt-Peterburg

Maslevtsov D.V.

Pavlov First St. Petersburg State Medical University, St. Petersburg, Russia

Krivov V.O.

Pavlov First St. Petersburg State Medical University, St. Petersburg, Russia

Beskrovnaya O.V.

Pavlov First St. Petersburg State Medical University, St. Petersburg, Russia

Molchan N.S.

Pavlov First St. Petersburg State Medical University, St. Petersburg, Russia

Close metadata

References:

  1. van Harten AE, Scheeren TW, Absalom AR. A review of postoperative cognitive dysfunction and neuroinflammation associated with cardiac surgery and anaesthesia. Anaesthesia. 2012;66:280-293. https://doi.org/10.1111/j.1365-2044.2011.07008.x
  2. Eckenhoff RG, Laudansky KF. Anesthesia, surgery, illness and Alzheimers disease. Prog Neuropsychopharmacol Biol Psychiatry. 2013;47:162-166. https://doi.org/10.1016/j.pnpbp.2012.06.011
  3. Riedel B, Browne K, Silbert B. Cerebral protection: inflammation, endothelial dysfunction and postoperative cognitive dysfunction. Curr Opin Anaesthesiol. 2014;27:89-97. https://doi.org/10.1097/aco.0000000000000032
  4. Silva FP, Schmidt AP, Valentin LS, Pinto KO, Zeferino SP, Oses JP, Wiener CD, Otsuki DA, Tort ABL, Portela LV, Souza DO, Auler JOC Jr, Carmona MJC. S100B protein and neuron-specific enolase as predictors of cognitive dysfunction after coronary artery bypass graft surgery: A prospective observational study. Eur J Anaesthesiol. 2016;33:681-689. https://doi.org/10.1097/eja.0000000000000450
  5. Fedin AI, Kuznetsov MR, Beresteny NF, Kholopova EA, Tugdumov BV, Rumyantseva EI, Pavochkina ES. State of the brain blood flow autoregulation. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2011;111(1):68. (In Russ.)
  6. Shevchenko YL, Mikhailenko AA, Kuznetsov AN, Erofeev AA. Kardiokhirurgicheskaya agressiya i golovnoi mozg: Tserebral’naya gemodinamika i nevrologicheskie iskhody operatsii na serdtse. SPb.: Nauka; 1997. (In Russ.)
  7. Vlasov TD, Baysa AE, Shmonin AA, Vavilov VN, Melnikova EV. Protective effect of ischemic preconditioning in focal cerebral ischemia rats for various durations. Clinical pathophysiology. 2008;1:54-57. (In Russ.)
  8. Zeitlin AM, Lubnin AYu, Zelman VL, Eliava SS. Ischemic preconditioning of the brain. J Patol circ and cardiosurg. 2010;3: 14-22. (In Russ.)
  9. Karpova ES, Kotelnikova EV, Lyamina NP. Ischemic preconditioning and its cardioprotective effect in post-intervention cardiac rehabilitation programmes for patients with coronary heart disease. Russ J Cardiol. 2012;4(96):104-108. (In Russ.)
  10. Bilotta F, Gelb WA, Stazi E, Titi FP, Paoloni GR. Pharmacological perioperative brain neuroprotection: a qualitative review of randomized clinical trials. Br J Anaesth. 2013;110(suppl 1):113-120. https://doi.org/10.1093/bja/aet059
  11. Petrishchev NN, Shlyakhto EV, Galagudza MM. New methods of myocardial protection from ischemic and reperfusion injury: molecular mechanisms and prospects of clinical application. J Cardiology. 2007;5:179-184. (In Russ.)
  12. Lebuffe G, Schumacker PT, Shao ZH, Anderson T, Iwase H, Vanden Hoek TL. ROS and NO trigger early preconditioning: relationship to mitochondrial KATP channel. Am J Physiol Heart Circ Physiol. 2003;284(1):299-308. https://doi.org/10.1152/ajpheart.00706.2002
  13. Kristiansen SB, Henning O, Kharbanda RK, Nielsen-Kudsk JE, Schmidt MR, Redington AN, Nielsen TT, Botker HE. Remote preconditioning reduces ischemic injury in the explanted heart by a KATP channeldependent Mechanism. Am J Physiol Heart Circ Physiol. 2005;288(3):1252-1256. https://doi.org/10.1152/ajpheart.00207.2004
  14. Meyer K, Schipke JD, Klocke R, Gams E, Korbmacher B. Inotropic, vasodilating and preconditioning actions of levosimendan in the heart. Thorac Cardiovasc Surg. 2008;56:379-385. PMID: 18810693. https://doi.org/10.1055/s-2008-1038729
  15. Todosiychuk VV, Kuznetsov VA, Nokhrina OYu, Lykasova EA, Pak YuA. Assessment of the late phase of myocardial ischemic preconditioning in patients with coronary artery disease. Herald of Arrhythmology. 2010;61:30-32. (In Russ.)
  16. Bolli R, Li QH, Tang XL, Guo Y, Xuan Y-T, Rokosh G, Dawn B. The late phase of preconditioning and its natural clinical application-gene therapy. Heart Fail Rev. 2007;12:189-199. https://doi.org/10.1007/s10741-007-9031-4
  17. Zhao XS, Pan W, Bokcredjian R, Shohet RV. Endogenous endothelial is required for cardiomyocyte survival in vivo. Circulation. 2006;114(8):830-837. https://doi.org/10.1161/circulationaha.105.577288
  18. Dirnagl U, Simon RP, Hallenbeck JM. Ischemic tolerance and endogenous neuroprotection. Trends Neurosci. 2003;26(5)248-254. https://doi.org/10.1016/s0166-2236(03)00071-7
  19. Wang G-W, Klein JB, Kang YJ. Metallothionein inhibits doxorubicin-induced mitochondrial cytochrome с release and caspase-3 activation in cardiomyocytes. J Pharmacol Exp Ther. 2001;298:461-468.
  20. Johnston S, O’Meara S, Manolio A. Cognitive Impairment and Decline Are Associated with Carotid Artery Disease in Patients without Clinically Evident Cerebrovascular Disease. Ann Intern Med. 2004;140:237-247. https://doi.org/10.1016/j.accreview.2004.04.036
  21. Grebenchikov OA, Zabelina TS, Filippovskaya JS, Gerasimenko ON, Ovezov AM, Plotnikov EY, Likhvantsev VV. Oxidative stress in cardiac surgery. Bulletin of anesthesiology and critical care medicine. 2016;13(4)53-60. (In Russ.)
  22. Odinak MM, Voznyuk IA, Yanishevskii SN. Ishemiya mozga. Neiroprotektivnaya terapiya. Differentsirovannyi podkhod. SPb.: VMedA; 2002. (In Russ.)
  23. Odinak MM, Yanishevsky SN, Voznyuk IA, Tsygan NV. Neurotransmitter therapy of stroke: the results of the studies. Effective pharmacotherapy. 2013;45(4):6-12. (In Russ.)
  24. Minnerup J, Sevimli S, Schabitz W-R. Granulocyte-colony stimulating factor for stroke treatment: mechanisms of action and efficacy in preclinical studies. Exp Transl Stroke Med. 2009;1:2. https://doi.org/10.1186/2040-7378-1-2
  25. Shmonin AA, Krasnov VS, Smolina IA, Melnikova EV. Modern therapy of chronic disorders of cerebral circulation. Part 1. Archives of internal medicine. 2014;3(17):12-17. (In Russ.)
  26. Huang F, Zhou L. Effect of mild hypothermia on the changes of cerebral blood flow, brain blood barrier and neuronal injuries following reperfusion of focal cerebral ischemia in rats. Chin Med J (Engl). 1998;111(4):368-372.
  27. Huang ZG, Xue D, Preston E, Karbalai H, Buchan AM, Preston E. Biphasic opening of the blood-brain barrier following transient focal ischemia: effects of hypothermia. Can J Neurol Sci. 1999;26:298-304. https://doi.org/10.1017/s0317167100000421
  28. Pan J, Konstas AA, Bateman B, Ortolano GA, Pile-Spellman J. Reperfusion injury following cerebral ischemia: pathophysiology, MR imaging, and potential therapies. Neuroradiology. 2007;49(2):93-102. https://doi.org/10.1007/s00234-006-0183-z
  29. Krieger DW, De Georgia MA, Abou-Chebl A, Andrefsky JC, Sila CA, Katzan IL, Mayberg MR, Furlan AJ. Cooling for acute ischemic brain damage (cool aid): an open pilot study of induced hypothermia in acute ischemic stroke. Stroke. 2001;32:1847-1854. https://doi.org/10.1161/01.str.32.8.1847
  30. Schwab S, Georgiadis D, Berrouschot JP, Schellinger D, Graffagnino C, Mayer SA. Feasibility and safety of moderate hypothermia after massive hemispheric infarction. Stroke. 2001;32:2033-2035. https://doi.org/10.1161/hs0901.095394
  31. De Georgia MA, Krieger DW, Abou-Chebl A, Devlin TG, Jauss M, Davis SM, Koroshetz WJ, Rordorf G, Warach S. Cooling for acute ischemic brain damage (COOL AID): a feasibility trial of endovascular cooling. Neurology. 2004;63:312-317. https://doi.org/10.1212/01.wnl.0000129840.66938.75
  32. Neymark MI, Shmelev VV, Simagin VY, Elizarev AYu, Subbotin EA. Choice of Anesthesia Mode, Neuroprotective Therapy in the Surgical Repair of Extracranial Vessels. General reanimatology. 2011;7(5):20-27. (In Russ.)
  33. Ovezov AM, Bragin, SV, Prokoshev PV. Cytoflavin in total intravenous anesthesia. Bulletin of surgery. 2010;169(2):64-67. (In Russ.)
  34. Ovezov AM, Lobov MA, Nadkina ED Citicoline in the prevention of postoperative cognitive dysfunction during total intravenous anesthesia. Annals of clinical and experimental neurology. 2013;7(2):27-34. (In Russ.)
  35. Usenko LV, Kristofor AA, Polischuk IS, Tiutiunnik AH, Usenko AA, Petrashenok YeV. Postoperative cognitive dysfunction as a complication of General anesthesia. The importance of early pharmacological neuroprotection. Medicine of emergency. 2015;2(65):24-31. (In Russ.)
  36. Nasreddine ZS, Phillips NA, Bedirian V, Charbonneau S, Whitehead V, Collin I, Cummings JL, Chertkow H. The Montreal Cognitive Assessment (MoCA): A Brief Screening Tool For Mild Cognitive Impairment. Journal of the American Geriatrics Society. 2005;53:695-699. https://doi.org/10.1111/j.1532-5415.2005.53221.x
  37. Folstein MF, Folstein SE, McHugh PR. «Mini-mental state». A practical method for grading the cognitive state of patients for the clinician». Journal of psychiatric research. 1975;12(3):189-198. https://doi.org/10.1016/0022-3956(75)90026-6
  38. Dubois B, Litvan I. The FAB: A frontal assessment battery at bedside. Neurology. 2000;55(11):1621-1626. https://doi.org/10.1212/wnl.55.11.1621
  39. Zigmond AC, Snaith RP. The Hospital Anxiety and Depression scale. Acta Psychiatr Scand. 1983;67:361-370. https://doi.org/10.1111/j.1600-0447.1983.tb09716.x
  40. Lovenstone S, Gauthier S. Management of dementia. London: Martin Dunitz; 2001. https://doi.org/10.1016/s0303-8467(01)00179-2
  41. Huskisson EC. Measurement of pain. The Lancet. 1974;9(2):1127-1131. https://doi.org/10.1016/s0140-6736(74)90884-8
  42. Brooks R, Rabin R, de Charro F. The measurement and valuation of health status using EQ-5D: a European perspective. Kluwer Academic Publishers. 2003. https://doi.org/10.1007/978-94-017-0233-1
  43. Semin GF, Ivanov YuS, Lokyan AB, Mkrtchyan MS. Praktikum po ul’trazvukovoi dopplerografii arterii golovy i mozga. Erevan: Izd-vo EMI; 2000. (In Russ.)
  44. Kuznetsov AN, Voznyuk IA. Spravochnik po tserebral’noi dopplerografii. Pod red. Odinaka M.M. M.: ZAO Spektromed; 2004. (In Russ.)
  45. Voznyuk IA, Polushin A Yu, Stepanov EA. Quantitative evaluation of ultrasonic parameters of cerebral blood flow (value and norm). Regional circulation and microcirculation. 2013;4(47):12-18. (In Russ.)
  46. Register of medicines of Russia: encyclopedia of medicine. Chief editor Krylov Y.F. Cerebrolysin. Abstract to the drug. The link is active on: 16.11.17. (In Russ.) http://www.rlsnet.ru/t_index_id_3528.htm
  47. Macfarlane R, Tasdemiroglu E, Moskowitz MA, Uemura Y, Wei EP, Kontos HA. Chronic trigeminal ganglionectomy or topical capsaicin application to pial vessels attenuates postocclusive cortical hyperemia but does not influence postischemic hypoperfusion. J Cereb Blood Flow Metab. 1991;11:261-271. https://doi.org/10.1038/jcbfm.1991.58
  48. Shuleshova NV, Vishnevskii AA, Kul’chitskii VA, Trofimova TN, Kondrat’ev AN, Kondrat’eva EA, Skoromets AA. Stvol golovnogo mozga: (klinicheskie i patomorfologicheskie sootvetstviya). Izd. 2-e, pererab. I dop. SPb.: Foliant; 2016. (In Russ.)
  49. Hughes CG, Morandi A, Girard TD, Riedel B, Thompson JL, Shintani AK, Pun BT, Ely EW, Pandharipande PP. Association between endothelial dysfunction and acute brain dysfunction during critical illness. Anesthesiology. 2013;118(3):631-639. https://doi.org/10.1097/aln.0b013e31827bd193
  50. Shiroyama Y, Nagamitsu Т, Yamashita K, Yamashita T, Abiko S, Ito H. Changes in brain stem blood flow under various grades of brain stem ischemia. Tohoku J Exp Med. 1991;164:237-246. https://doi.org/10.1620/tjem.164.237
  51. Grigore AM, Murray CF, Ramakrishna H, Djaiani G. A core review of temperature regimens and neuroprotection during cardiopulmonary bypass: does rewarming rate matter? Anesthesia and Analgesia. 2009;109:1741-1751. https://doi.org/10.1213/ane.0b013e3181c04fea
  52. Joshi B, Brady K, Lee J, Easley B, Panigrahi R, Smielewski P, Czosnyka M, Hogue CW. Impaired autoregulation of cerebral blood flow during rewarming from hypothermic cardiopulmonary bypass and its potential association with stroke. Anesthesia and Analgesia. 2010;110:321-328. https://doi.org/10.1213/ane.0b013e3181c6fd12
  53. Levin EA, Postnov VG, Kasatkina AG, Zhukova OV. Postoperative cognitive dysfunction in cardiac surgery: pathogenesis, morphological and functional correlates, diagnosis. Bulletin of the Siberian branch of the Russian Academy of medical Sciences. 2013;33(4):90-106. (In Russ.)
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.