Genetic and clinical predictors of treatment efficacy in depressive disorders

Ivanets N.N.; Kinkul'kina M.A.; Tikhonova Iu.G.; Iziumina T.A.; Avdeeva T.I.; Morozov D.I.

doi:https://doi.org/10.17116/jnevro201711710155-64

Ivanets N.N.

Kafedra psikhiatrii i meditsinskoĭ psikhologii Moskovskoĭ meditsinskoĭ akademii im. I.M. Sechenova

Kinkul'kina M.A.

Kafedra psikhiatrii i meditsinskoĭ psikhologii Moskovskoĭ meditsinskoĭ akademii im. I.M. Sechenova

Tikhonova Iu.G.

Kafedra psikhiatrii i narkologii GBOU VPO "Pervyĭ Moskovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.M. Sechenova" Minzdrava RF;
Nauchno-obrazovatel'nyĭ klinicheskiĭ tsentr "Psikhicheskoe zdorov'e", Moskva

Iziumina T.A.

Sechenov First Moscow State Medical University, Moscow

Avdeeva T.I.

Morozov D.I.

Sechenov First Moscow State Medical University, Moscow, Russia

Genetic and clinical predictors of treatment efficacy in depressive disorders

Authors:

Ivanets N.N., Kinkul'kina M.A., Tikhonova Iu.G., Iziumina T.A., Avdeeva T.I., Morozov D.I.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2017;117(10): 55‑64

DOI: 10.17116/jnevro201711710155-64

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To cite this article:

Ivanets NN, Kinkul'kina MA, Tikhonova IuG, Iziumina TA, Avdeeva TI, Morozov DI. Genetic and clinical predictors of treatment efficacy in depressive disorders. S.S. Korsakov Journal of Neurology and Psychiatry. 2017;117(10):55‑64. (In Russ.)
https://doi.org/10.17116/jnevro201711710155-64

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)

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Abstract:

Objective. To study clinical and genetic characteristics that impact on the efficacy of pharmacotherapy of depressive disorders. Material and methods. The study included 188 patients with unipolar depressive disorders of different genesis (psychogenic, endogenous and organic). A clinical-psychopathological method and depression psychometric scales were used. Serotonin transporter 5-HTTLPR and STin2 and dopamine transporter 3',-VNTR polymorphisms were determined. Results and conclusion. The S-allele of the 5-HTTLPR polymorphism is associated with the low efficacy of treatment with selective serotonin reuptake inhibitors. Tricyclic antidepressants are more effective in treatment of psychogenic depression. The authors determined clinical factors that can predict response to treatment of psychogenic and endogenous depression. No predictors were found for organic depression.

Keywords:

depression

antidepressants

efficacy

predictors

pharmacogenetics

individualized treatment

5-HTTLPR

Authors:

Ivanets N.N.

Kafedra psikhiatrii i meditsinskoĭ psikhologii Moskovskoĭ meditsinskoĭ akademii im. I.M. Sechenova

Kinkul'kina M.A.

Kafedra psikhiatrii i meditsinskoĭ psikhologii Moskovskoĭ meditsinskoĭ akademii im. I.M. Sechenova

Tikhonova Iu.G.

Iziumina T.A.

Sechenov First Moscow State Medical University, Moscow

Avdeeva T.I.

Morozov D.I.

Sechenov First Moscow State Medical University, Moscow, Russia

Close metadata

References:

Federal’nye klinicheskie rekomendatsii po diagnostike i lecheniyu rekurrentnogo depressivnogo rasstroistva. Proekt. М. 2013. (In Russ.)
Bauer M, Pfennig A, Severus E, Whybrow PC, Angst J, Möller H-J. Klinicheskie rekomendatsii Vsemirnoi federatsii obshchestv biologicheskoi psikhiatrii po biologicheskoi terapii unipolyarnykh depressivnykh rasstroistv. Chast’ 2: Ostroe i prodolzhennoe lechenie unipolyarnykh depressivnykh rasstroistv po sostoyaniyu na 2013 g. Sovremennaya terapiya psikhicheskikh rasstroistv. 2016;1:31-48. (In Russ.)
Mosolov S.N. Klinicheskoe primenenie sovremennykh antidepressantov. SPb.: Meditsinskoe informatsionnoe agentstvo; 1997. (In Russ.)
Standart spetsializirovannoi meditsinskoi pomoshchi bol’nym s depressiyami s psikhoticheskimi simptomami, tyazheloi stepeni tyazhesti v statsionarnykh usloviyakh. Federal’nyi Zakon №323 «Ob osnovakh okhrany zdorov’ya grazhdan v Rossiiskoi Federatsii». 2012. (In Russ.)
Bauer M, Pfennig A, Severus E, Whybrow PC, Angst J, Möller H-J. World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for Biological Treatment of Unipolar Depressive Disorders. Part 1: Update 2013 on the acute and continuation treatment of unipolar depressive disorders. Sovremennaya terapiya psikhicheskikh rasstroistv. 2015;28-40. (In Russ.). Accessed July 26, 2017. (In Russ.)
National Guideline Clearinghouse (NGC). Guideline summary: Practice guideline for the treatment of patients with major depressive disorder, third edition. In: National Guideline Clearinghouse (NGC) [Web site]. Rockville (MD): Agency for Healthcare Research and Quality (AHRQ); 2010 Oct 01. https://guideline.gov
Trivedi MH, Rush AJ, Wisniewski SR, et al. Evaluation of outcomes with citalopram for depression using measurement-based care in STAR*D: implications for clinical practice. Am J Psychiatry. 2006;163(1):28-40. https://doi.org/10.1176/appi.ajp.163.1.28
Rush AJ. Limitations in efficacy of antidepressant monotherapy. J Clin Psychiatry. 2007;68(suppl 10):8-10.
Keitner GI, Ryan CE, Miller IW, Norman WH. Recovery and major depression: factors associated with twelve-month outcome. Am J Psychiatry. 1992;149:93-99. https://doi.org/10.1176/ajp.149.1.93
Olfson M, Marcus S, Tedeschi M. Continuity of antidepressant treatment for adults with depression in the United States. Am J Psychiatry. 2006;163: 101-108. https://doi.org/10.1176/appi.ajp.163.1.101
Freedman R, Lewis DA, Michels R, Pine DS, Schultz SK, Tamminga CA, et al. The initial field trials of DSM-5: new blooms and old thorns. Am J Psychiatry. 2013;170:1-5. https://doi.org/10.1176/appi.ajp.2012.12091189
Papakostas GI, Fava M. Dialogues. Clin Neurosci. 2008;10(4):439-451.
Kemp AH, Gordon E, Rush J, Leanne M, Williams M. Improving the prediction of treatment response in depression: integration of clinical, cognitive, psychophysiological, neuroimaging and genetic measures. CNS Spectr. 2008;13:1066-1086. https://doi.org/10.1017/S1092852900017120
Leuchter AF, Cook IA, Hamilton SP, et al. Biomarkers to predict antidepressant response. Curr Psychiatry Rep. 2010;12:553-562. https://doi.org/10.1007/s11920-010-0160-4
Smith DF. Quest for biomarkers of treatment-resistant depression: shifting the paradigm toward risk. Front Psychiatry. 2013;4:57. https://doi.org/10.3389/fpsyt.2013.00057
Hajek T, Kozeny J, Kopecek M, et al. Reduced subgenual cingulate volumes in mood disorders: a meta-analysis. J Psychiatry Neurosci. 2008;33: 91-99.
McKinnon M, Yucel K, Nazarov A, MacQueen G. A meta-analysis examining clinical predictors of hippocampal volume in patients with major depressive disorder. J Psychiatry Neurosci. 2009;34:41-54.
Mayberg HS, Brannan SK, Tekell JL, et al. Regional metabolic effects of fluoxetine in major depression: serial changes and relationship to clinical response. Biol Psychiatry. 2000;48:830-843. https://doi.org/10.1016/s0006-3223(00)01036-2
Table of Pharmacogenomic Biomarkers in Drug Labeling. http://www.fda.gov/Drugs/ScienceResearch/ResearchAreas/Pharmacogenetics/ucm083378.htm
Serretti A, Kato M, De Ronchi D, et al. Meta-analysis of serotonin transporter gene promoter polymorphism (5-HTTLPR) association with selective serotonin reuptake inhibitor efficacy in depressed patients. Mol Psychiatry. 2006;12:247-257. https://doi.org/10.1038/sj.mp.4001926
Porcelli S, Fabbri C, Serretti A. Meta-analysis of serotonin transporter gene promoter polymorphism (5-HTTLPR) association with antidepressant efficacy. Eur Neuropsychopharmacol. 2012;22(4):239-258. https://doi.org/10.1016/j.euroneuro.2011.10.003
Karlović D, Karlović D. Serotonin transporter gene (5-HTTLPR) polymorphism and efficacy of selective serotonin reuptake inhibitors — do we have sufficient evidence for clinical practice. Acta Clin Croat. 2013;52(3):353-362.
Serretti A, Olgiati P, Bajo E, Bigelli M, De Ronchi D. A model to incorporate genetic testing (5-HTTLPR) in pharmacological treatment of major depressive disorders. World J Biol Psychiatry. 2011;12(7):501-515. https://doi.org/10.3109/15622975.2011.572998
Kunugi H, Hattori M, Kato T, Tatsumi M, Sakai T, Sasaki T, et al. Serotonin transporter gene polymorphisms: ethnic difference and possible association with bipolar affective disorder. Mol Psychiatry. 1997;2:457-462. https://doi.org/10.1038/sj.mp.4000334
Kang AM, Palmatier MA, Kidd KK. Global Variation of a 40-bp VNTR in the 3’-Untranslated Region of the Dopamine Transporter Gene (SLC6A3). Biol Psychiatry. 1999;46:151-160. https://doi.org/10.1016/s0006-3223(99)00101-8
Rebrova OYu. Statisticheskii analiz meditsinskikh dannykh. Primenenie paketa prikladnykh programm Statistica. M.: Media Sphera; 2002. (In Russ.)
Jaspers K. General Psychopathology. M.: Praktika; 1997. (In Russ.)
Tiganov AS. Endogennye depressii: voprosy klassifikatsii i sistematiki. Depressii i komorbidnye rasstroistva. Pod red. Smulevicha A.B. M. 1997. (In Russ.)
Krasnov VN. Rasstroistva affektivnogo spectra. M.: Prakticheskaya meditsina; 2011. (In Russ.)
Krasnov VN. Organic and somatogenous depressions in general medical practice. Doctor.ru. 2009;4:52-54. (In Russ.)