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Kibitov A.O.

Laboratoriia molekuliarnoĭ genetiki Natsional'nogo nauchnogo tsentra narkologii, Moskva

Mazo G.

Sankt-Peterburgskiĭ nauchno-issledovatel'skiĭ psikhonevrologicheskiĭ institut im. V.M. Bekhtereva;
Sankt-Peterburgskiĭ gosudarstvennyĭ universitet, Sankt-Peterburg

Genetic aspects of binge eating disorder Part 2. Molecular genetics and pharmacogenetic approaches

Authors:

Kibitov A.O., Mazo G.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(8): 102‑108

DOI: 10.17116/jnevro201611681102-108

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GENETIC ASPECTS OF BINGE EATING DISORDER PART 2. MOLECULAR GENETICS AND PHARMACOGENETIC APPROACHES
GENETIC ASPECTS OF BINGE EATING DISORDER PART 2. MOLECULAR GENETICS AND PHARMACOGENETIC APPROACHES

To cite this article:

Kibitov AO, Mazo G. Genetic aspects of binge eating disorder Part 2. Molecular genetics and pharmacogenetic approaches. S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(8):102‑108. (In Russ.)
https://doi.org/10.17116/jnevro201611681102-108

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
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Abstract:

Genetic risk of binge eating disorder (ВЕD) is a consequence of joint participation of many genes, the contribution of each one is small, but the total (additive) effect is significant and greatly influences the age at onset, clinical dynamics and the level of treatment resistance. It is assumed that the carriers of different polymorphic variants of genes and their combinations have different levels of genetic risk. No Genom Wide Association studies of ВЕD has been performed and the analysis of the results of candidate genes studies gives reason to believe that pathogenetically substantiated panel of genes, including serotonin system, BDNF and, especially dopamine and endogenous opioid system, would be most useful, taking into account the mechanism of action of drugs for the ВЕD treatment. Genetic studies with this panel if using evidence-based design, detailed and quantitative analysis of the family history of binge eating can give good results for: 1) assessment of the genetic risk of ВЕD for primary prevention programs; 2) identification of the specific clinical forms of development and course of ВЕD with significant genetic influence; 3) identification of the specific genetic variants that increase the effectiveness of personalized pharmacotherapy of ВЕD within pharmacogenetic approach.

Keywords:

binge eating disorder
genetics
depression
addiction
obesity
gene polymorphism
serotonin
dopamine
endogenous opioid system
BDNF

Authors:

Kibitov A.O.

Laboratoriia molekuliarnoĭ genetiki Natsional'nogo nauchnogo tsentra narkologii, Moskva

Mazo G.

Sankt-Peterburgskiĭ nauchno-issledovatel'skiĭ psikhonevrologicheskiĭ institut im. V.M. Bekhtereva;
Sankt-Peterburgskiĭ gosudarstvennyĭ universitet, Sankt-Peterburg

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References:

  1. Thornton L, Mazzeo S, Bulik C. The heritability of eating disorders: methods and current findings. Curr Top Behav Neurosci. 2011;6:141-156.  doi: 10.1007/7854_2010_91
  2. Trace S, Baker J, Peñas-Lledó E, Bulik C. The genetics of eating disorders. Annu Rev Clin Psychol. 2013;9:589-620.  doi: 10.1146/annurev-clinpsy-050212-185546
  3. Javaras K, Laird N, Reichborn-Kjennerud T, Bulik C, Pope H, Hudson J. Familiality and heritability of binge eating disorder: Results of a case-control family study and a twin study. Int J Eat Disord. 2008;41(2):174-179.  doi: 10.1002/eat.20484
  4. Rikani A, Choudhry Z, MaqsoodChoudhry A et al. A critique of the literature on etiology of eating disorders. ANS. 2013;20(4). doi: 10.5214/ans.0972.7531.200409
  5. Helder SG, Collier DA. The genetics of eating disorders. Curr Top Behav Neurosci. 2011;6:157-175.  doi: 10.1007/7854_2010_79
  6. Davis C. The epidemiology and genetics of binge eating disorder (BED). CNS Spectrums. 2015;1-8.  doi: 10.1017/s1092852915000462
  7. Vannucci A, Tanofsky-Kraff M, Ranzenhofer L et al. Puberty and the manifestations of loss of control eating in children and adolescents. Int J Eat Disord. 2014;47(7):738-747.  doi: 10.1002/eat.22305
  8. Fairweather-Schmidt A, Wade T. DSM-5 eating disorders and other specified eating and feeding disorders: Is there a meaningful differentiation? Int J Eat Disord. 2014;47(5):524-533.  doi: 10.1002/eat.22257
  9. Racine S, Keel P, Burt S et al. Exploring the relationship between negative urgency and dysregulated eating: Etiologic associations and the role of negative affect. Journal of Abnormal Psychology. 2013;122(2):433-444.  doi: 10.1037/a0031250
  10. Koren R, Munn-Chernoff M, Duncan A et al. Is the Relationship Between Binge Eating Episodes and Personality Attributable to Genetic Factors? Twin Research and Human Genetics. 2014;17(02):65-71.  doi: 10.1017/thg.2013.92
  11. Steiger H, Bruce KR. Phenotypes, endophenotypes, and genotypes in bulimia spectrum eating disorders. Can J Psychiatry. 2007;52(4):220-227.
  12. Davis C, Levitan R, Yilmaz Z, Kaplan A, Carter J, Kennedy J. Binge eating disorder and the dopamine D2 receptor: Genotypes and sub-phenotypes. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2012;38(2):328-335.  doi: 10.1016/j.pnpbp.2012.05.002
  13. Mitchell K, Neale M, Bulik C, Aggen S, Kendler K, Mazzeo S. Binge eating disorder: a symptom-level investigation of genetic and environmental influences on liability. Psychological Medicine. 2010;40(11):1899-1906. doi: 10.1017/s0033291710000139
  14. Winham S, Cuellar-Barboza A, McElroy S et al. Bipolar disorder with comorbid binge eating history: A genome-wide association study implicates APOB. Journal of Affective Disorders. 2014;165:151-158.  doi: 10.1016/j.jad.2014.04.026
  15. Hildebrandt T, Alfano L, Tricamo M, Pfaff D. Conceptualizing the role of estrogens and serotonin in the development and maintenance of bulimia nervosa. Clinical Psychology Review. 2010;30(6):655-668.  doi: 10.1016/j.cpr.2010.04.011
  16. Cellini E, Castellini G, Ricca V et al. Glucocorticoid receptor gene polymorphisms in Italian patients with eating disorders and obesity. Psychiatric Genetics. 2010;20(6):282-288.  doi: 10.1097/ypg.0b013e32833a2142
  17. Day J, Ternouth A, Collier DA. Eating disorders and obesity: two sides of the same coin? Epidemiol Psichiatr Soc. 2009;18(2):96-100.
  18. Monteleone P, Zanardini R, Tortorella A et al. The 196G/A (val66met) polymorphism of the BDNF gene is significantly associated with binge eating behavior in women with bulimia nervosa or binge eating disorder. Neuroscience Letters. 2006;406(1-2):133-137.  doi: 10.1016/j.neulet.2006.07.040
  19. Kindler J, Bailer U, de Zwaan M et al. No association of the neuropeptide Y (Leu7Pro) and ghrelin gene (Arg51Gln, Leu72Met, Gln90Leu) single nucleotide polymorphisms with eating disorders. Nord J Psychiatry. 2011;65(3):203-207.  doi: 10.3109/08039488.2010.525258
  20. Ando T, Komaki G, Nishimura H et al. A ghrelin gene variant may predict crossover rate from restricting-type anorexia nervosa to other phenotypes of eating disorders: a retrospective survival analysis. Psychiatric Genetics. 2010;20(4):153-159.  doi: 10.1097/ypg.0b013e32833a1f0e
  21. Ando T, Komaki G, Naruo T et al. Possible role of preproghrelin gene polymorphisms in susceptibility to bulimia nervosa. Am J Med Genet. 2006;141B(8):929-934.  doi: 10.1002/ajmg.b.30387
  22. Monteleone P, Tortorella A, Castaldo E, Di Filippo C, Maj M. The Leu72Met polymorphism of the ghrelin gene is significantly associated with binge eating disorder. Psychiatric Genetics. 2007;17(1):13-16.  doi: 10.1097/ypg.0b013e328010e2c3
  23. Valette M, Bellisle F, Carette C et al. Eating behaviour in obese patients with melanocortin-4 receptor mutations: a literature review. Int J Obes Relat Metab Disord. 2012;37(8):1027-1035. doi: 10.1038/ijo.2012.169
  24. Lubrano-Berthelier C, Dubern B, Lacorte J et al. Melanocortin 4 Receptor Mutations in a Large Cohort of Severely Obese Adults: Prevalence, Functional Classification, Genotype-Phenotype Relationship, and Lack of Association with Binge Eating. The Journal of Clinical Endocrinology & Metabolism. 2006;91(5):1811-1818. doi: 10.1210/jc.2005-1411
  25. Tao Y, Segaloff D. Functional Analyses of Melanocortin-4 Receptor Mutations Identified from Patients with Binge Eating Disorder and Nonobese or Obese Subjects. The Journal of Clinical Endocrinology & Metabolism. 2005;90(10):5632-5638. doi: 10.1210/jc.2005-0519
  26. Potoczna N, Branson R, Kral J et al. Gene variants and binge eating as predictors of comorbidity and outcome of treatment in severe obesity. Journal of Gastrointestinal Surgery. 2004;8(8):971-982.  doi: 10.1016/j.gassur.2004.09.032
  27. Hebebrand J, Geller F, Dempfle A et al. Binge-eating episodes are not characteristic of carriers of melanocortin-4 receptor gene mutations. Molecular Psychiatry. 2004;9(8):796-800.  doi: 10.1038/sj.mp.4001491
  28. Gorwood P. Eating Disorders, Serotonin Transporter Polymorphisms and Potential Treatment Response. American Journal of Pharmaco Genomics. 2004;4(1):9-17.  doi: 10.2165/00129785-200404010-00002
  29. Koren R, Duncan A, Munn-Chernoff M et al. Preliminary evidence for the role of HTR2A variants in binge eating in young women. Psychiatric Genetics. 2014;24(1):28-33.  doi: 10.1097/ypg.0000000000000014
  30. Nishiguchi N, Matsushita S, Suzuki K, Murayama M, Shirakawa O, Higuchi S. Association between 5HT2A receptor gene promoter region polymorphism and eating disorders in Japanese patients. Biological Psychiatry. 2001;50(2):123-128.  doi: 10.1016/s0006-3223(00)01107-0
  31. Monteleone P, Maj M. Genetic susceptibility to eating disorders: associated polymorphisms and pharmacogenetic suggestions. Pharmacogenomics. 2008;9(10):1487-1520. doi: 10.2217/14622416.9.10.1487
  32. Burnet P, Smith K, Cowen P, Fairburn C, Harrison P. Allelic variation of the 5-HT2C receptor (HTR2C) in bulimia nervosa and binge eating disorder. Psychiatric Genetics. 1999;9(2):101-104.  doi: 10.1097/00041444-199906000-00009
  33. Monteleone P, Tortorella A, Martiadis V, Serino I, Di Filippo C, Maj M. Association between A218C polymorphism of the tryptophan-hydroxylase-1 gene, harm avoidance and binge eating behavior in bulimia nervosa. Neuroscience Letters. 2007;421(1):42-46.  doi: 10.1016/j.neulet.2007.05.018
  34. Castellini G, Ricca V, Lelli L et al. Association between serotonin transporter gene polymorphism and eating disorders outcome: A 6-year follow-up study. Am J Med Genet. 2012;159B(5):491-500.  doi: 10.1002/ajmg.b.32052
  35. Akkermann K, Nordquist N, Oreland L, Harro J. Serotonin transporter gene promoter polymorphism affects the severity of binge eating in general population. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2010;34(1):111-114.  doi: 10.1016/j.pnpbp.2009.10.008
  36. Akkermann K, Kaasik K, Kiive E, Nordquist N, Oreland L, Harro J. The impact of adverse life events and the serotonin transporter gene promoter polymorphism on the development of eating disorder symptoms. Journal of Psychiatric Research. 2012;46(1):38-43.  doi: 10.1016/j.jpsychires.2011.09.013
  37. Monteleone P, Tortorella A, Castaldo E, Maj M. Association of a functional serotonin transporter gene polymorphism with binge eating disorder. Am J Med Genet. 2005;141B(1):7-9.  doi: 10.1002/ajmg.b.30232
  38. Calati R, De Ronchi D, Bellini M, Serretti A. The 5-HTTLPR polymorphism and eating disorders: A meta-analysis. Int J Eat Disord. 2011;44(3):191-199.  doi: 10.1002/eat.20811
  39. Lee Y, Lin P. Association between serotonin transporter gene polymorphism and eating disorders: A meta-analytic study. Int J Eat Disord. 2010;43(6):498-504.  doi: 10.1002/eat.20732
  40. Munn-Chernoff M, Grant J, Agrawal A et al. Are there common familial influences for major depressive disorder and an overeating-binge eating dimension in both European American and African American Female twins? Int J Eat Disord. 2014;48(4):375-382.  doi: 10.1002/eat.22280
  41. Avena N. The study of food addiction using animal models of binge eating. Appetite. 2010;55(3):734-737.  doi: 10.1016/j.appet.2010.09.010
  42. Vaessen T, Hernaus D, Myin-Germeys I, van Amelsvoort T. The dopaminergic response to acute stress in health and psychopathology: A systematic review. Neuroscience & Biobehavioral Reviews. 2015;56:241-251.  doi: 10.1016/j.neubiorev.2015.07.008
  43. Davis C, Loxton N, Levitan R, Kaplan A, Carter J, Kennedy J. ‘Food addiction’ and its association with a dopaminergic multilocus genetic profile. Physiology & Behavior. 2013;118:63-69.  doi: 10.1016/j.physbeh.2013.05.014
  44. Shinohara M, Mizushima H, Hirano M et al. Eating disorders with binge-eating behaviour are associated with the S allele of the 3'-UTR VNTR polymorphism of the dopamine transporter gene. J Psychiatry Neurosci. 2004;29(2):134-137.
  45. Groleau P, Steiger H, Joober R et al. Dopamine-system genes, childhood abuse, and clinical manifestations in women with Bulimia-spectrum Disorders. Journal of Psychiatric Research. 2012;46(9):1139-1145. doi: 10.1016/j.jpsychires.2012.05.018
  46. Davis C, Levitan R, Kaplan A et al. Reward sensitivity and the D2 dopamine receptor gene: A case-control study of binge eating disorder. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2008;32(3):620-628.  doi: 10.1016/j.pnpbp.2007.09.024
  47. Davis C, Levitan R, Reid C et al. Dopamine for «Wanting» and Opioids for «Liking»: A Comparison of Obese Adults With and Without Binge Eating Obesity. 2009;17(6):1220-1225. doi: 10.1038/oby.2009.52
  48. Yilmaz Z, Kaplan A, Levitan R, Zai C, Kennedy J. Possible association of the DRD4 gene with a history of attention-deficit/hyperactivity disorder in women with bulimia nervosa. Int J Eat Disord. 2012;45(4):622-625.  doi: 10.1002/eat.20986
  49. Levitan R, Masellis M, Basile V et al. The dopamine-4 receptor gene associated with binge eating and weight gain in women with seasonal affective disorder: An evolutionary perspective. Biological Psychiatry. 2004;56(9):665-669.  doi: 10.1016/j.biopsych.2004.08.013
  50. Landgren S, Jerlhag E, Zetterberg H et al. Association of Pro-Ghrelin and GHS-R1A Gene Polymorphisms and Haplotypes With Heavy Alcohol Use and Body Mass. Alcoholism: Clinical and Experimental Research. 2008;32(12):2054-2061. doi: 10.1111/j.1530-0277.2008.00793.x
  51. Monteleone P, Tortorella A, Docimo L et al. Investigation of 3111T/C polymorphism of the CLOCK gene in obese individuals with or without binge eating disorder: Association with higher body mass index. Neuroscience Letters. 2008;435(1):30-33.  doi: 10.1016/j.neulet.2008.02.003
  52. Monteleone P, Tortorella A, Martiadis V, Di Filippo C, Canestrelli B, Maj M. The cDNA 385C to A missense polymorphism of the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH) is associated with overweight/obesity but not with binge eating disorder in overweight/obese women. Psychoneuroendocrinology. 2008;33(4):546-550.  doi: 10.1016/j.psyneuen.2008.01.004
  53. Damberg M. Transcription factor AP-2 and monoaminergic functions in the central nervous system. Journal of Neural Transmission. 2005;112(10):1281-1296. doi: 10.1007/s00702-005-0325-1
  54. Ramoz N, Versini A, Gorwood P. Eating disorders: an overview of treatment responses and the potential impact of vulnerability genes and endophenotypes. Expert Opinion on Pharmacotherapy. 2007;8(13):2029-2044. doi: 10.1517/14656566.8.13.2029
  55. Reas D, Grilo C. Pharmacological treatment of binge eating disorder: update review and synthesis. Expert Opinion on Pharmacotherapy. 2015;16(10):1463-1478. doi: 10.1517/14656566.2015.1053465
  56. Balestri M, Calati R, Serretti A, De Ronchi D. Genetic modulation of personality traits. International Clinical Psychopharmacology. 2014;29(1):1-15.  doi: 10.1097/yic.0b013e328364590b
  57. Mitchell K, Neale M, Bulik C et al. An investigation of weight suppression in a population-based sample of female twins. Int J Eat Disord. 2010;44(1):44-49.  doi: 10.1002/eat.20780
  58. Popik P, Kos T, Zhang Y, Bisaga A. Memantine reduces consumption of highly palatable food in a rat model of binge eating. Amino Acids. 2010;40(2):477-485.  doi: 10.1007/s00726-010-0659-3
  59. Nathan P, Bullmore E. From taste hedonics to motivational drive: central μ-opioid receptors and binge-eating behaviour. The International Journal of Neuropsychopharmacology. 2009;12(07):995.  doi: 10.1017/s146114570900039x
  60. Marazziti D, Corsi M, Baroni S et al. Latest advancements in the pharmacological treatment of binge eating disorder. Eur Rev Med Pharmacol Sci. 2012;16(15):2102-2107.
  61. Davis C, Levitan R, Kaplan A et al. Dopamine Transporter Gene (DAT1) Associated with Appetite Suppression to Methylphenidate in a Case-Control Study of Binge Eating Disorder. Neuropsychopharmacology. 2007;32(10):2199-2206. doi: 10.1038/sj.npp.1301348
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