Role of TNF (rs1800629) and TGF-β2 (rs1159268) genes polymorphisms in acne pathogenesis

Demina O.M.; Khataeva D.I.; Potekaev N.N.; Vaschenko S.I.; Kuznetsova A.A.

doi:https://doi.org/10.17116/klinderma202423041351

Demina O.M.

The Russian National Research Medical University named after N.I. Pirogov

ORCID: 0000-0001-9406-2787

Khataeva D.I.

The Russian National Research Medical University named after N.I. Pirogov

ORCID: 0000-0002-8955-2084

Potekaev N.N.

Pirogov Russian National Research Medical University;
Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology

ORCID: 0000-0002-9578-5490

Vaschenko S.I.

Pirogov Russian National Research Medical University

ORCID: 0009-0000-0022-4053

Kuznetsova A.A.

Pirogov Russian National Research Medical University

ORCID: 0009-0009-5168-0927

Role of TNF (rs1800629) and TGF-β2 (rs1159268) genes polymorphisms in acne pathogenesis

Authors:

Demina O.M., Khataeva D.I., Potekaev N.N., Vaschenko S.I., Kuznetsova A.A.

More about the authors

Journal: Russian Journal of Clinical Dermatology and Venereology. 2024;23(4): 351‑355

DOI: 10.17116/klinderma202423041351

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To cite this article:

Demina OM, Khataeva DI, Potekaev NN, Vaschenko SI, Kuznetsova AA. Role of TNF (rs1800629) and TGF-β2 (rs1159268) genes polymorphisms in acne pathogenesis. Russian Journal of Clinical Dermatology and Venereology. 2024;23(4):351‑355. (In Russ.)
https://doi.org/10.17116/klinderma202423041351

Подписка 2026 Клиническая дерматология и венерология (Russian Journal of Clinical Dermatology and Venereology)

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Abstract:

Acne (acne vulgaris) is an extremely common dermatosis with specific clinical manifestations on the skin in the form of comedones (open and closed), inflammatory elements (papules, pustules and nodules), scars and post-inflammatory pigmentation, which, according to various data, affects more than 90% of adolescents and causes scarring on average in 20% of them. Genetic predisposition occupies an important place among a number of factors that can influence the disease course, as evidenced by the results of numerous studies.

OBJECTIVE

To determine the SNP of TNF (rs1800629) and TGF-β2 (rs1159268) genes significance in the development of moderate acne.

MATERIAL AND METHODS

The clinical anamnestic and molecular genetic methods were used. The research involved 204 patients aged between 17 and 46 years. The study group consisted of 102 patients with moderate acne (45 (44.1%) men and 57 (55.9%) women) at the age from 17 to 44 years, the control group included 102 conditionally healthy subjects (41 (40.2%) men, 61 (59.8%) women) aged between 18 and 46 years. The association of polymorphisms of GG TNF (rs1800629) and AA TGF-β2 (rs1159268), which increase the risk of developing disease by 2.5 and 3 times, respectively, with the development of moderate acne has been identified. These data allow to use the named indicators as risk markers for the development of moderate acne.

Keywords:

acne

polymorphism of genes

TNF

TGF-β2

Authors:

Demina O.M.

The Russian National Research Medical University named after N.I. Pirogov

ORCID: 0000-0001-9406-2787

Khataeva D.I.

The Russian National Research Medical University named after N.I. Pirogov

ORCID: 0000-0002-8955-2084

Potekaev N.N.

Pirogov Russian National Research Medical University;
Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology

ORCID: 0000-0002-9578-5490

Vaschenko S.I.

Pirogov Russian National Research Medical University

ORCID: 0009-0000-0022-4053

Kuznetsova A.A.

Pirogov Russian National Research Medical University

ORCID: 0009-0009-5168-0927

Received:

24.04.2024

Accepted:

13.06.2024

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