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Trofimova S.A.

Nauchno-issledovatel'skiĭ psikhonevrologicheskiĭ institut im. V.M. Bekhtereva, otdelenie reabilitatsii nevrologicheskikh bol'nykh, Sankt-Peterburg

Dubinina E.E.

Nauchno-issledovatel'skiĭ psikhonevrologicheskiĭ institut im. V.M. Bekhtereva, otdelenie reabilitatsii nevrologicheskikh bol'nykh, Sankt-Peterburg

Balunov O.A.

Nauchno-issledovatel'skiĭ psikhonevrologicheskiĭ institut im. V.M. Bekhtereva, otdelenie reabilitatsii nevrologicheskikh bol'nykh, Sankt-Peterburg

V Leonova N.

State Research Institute of Highly Pure Biopreparations of FMBA, St. Petersburg, Russia

An experimental in vitro study of antioxidant and antiradical properties of cytoflavin, vinpocetine, actovegin and ethylmethylhydroxypyridine succinate

Authors:

Trofimova S.A., Dubinina E.E., Balunov O.A., V Leonova N.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(7): 46‑49

DOI: 10.17116/jnevro20161167146-49

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AN EXPERIMENTAL IN VITRO STUDY OF ANTIOXIDANT AND ANTIRADICAL PROPERTIES OF CYTOFLAVIN, VINPOCETINE, ACTOVEGIN AND ETHYLMETHYLHYDROXYPYRIDINE SUCCINATE
AN EXPERIMENTAL IN VITRO STUDY OF ANTIOXIDANT AND ANTIRADICAL PROPERTIES OF CYTOFLAVIN, VINPOCETINE, ACTOVEGIN AND ETHYLMETHYLHYDROXYPYRIDINE SUCCINATE

To cite this article:

Trofimova SA, Dubinina EE, Balunov OA, V Leonova N. An experimental in vitro study of antioxidant and antiradical properties of cytoflavin, vinpocetine, actovegin and ethylmethylhydroxypyridine succinate. S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(7):46‑49. (In Russ.)
https://doi.org/10.17116/jnevro20161167146-49

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
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Abstract:

Objective. To investigate experimentally in vitro the antioxidant and anti-radical activity of several drugs. Material and methods. Antioxidant activity was assessed by induced luminol-dependent chemiluminescence (CL). An impact on the generation of reactive oxygen species (O2-, OH, 1D, H2O2, HClO) and their ability to inhibit the auto-oxidation of quercetin combined with the generation of superoxide radical anion were determined. Anti-radical activity was studied by the method of restoring a stable radical α-α-diphenyl-β-picryl hydrazine (DPPH) molecule of the alleged anti-oxidant. Results and conclusion. The many-sided action of the drugs on the products of free radicals generated in the in vitro experiments has been shown. Only cytoflavin has the highest total antioxidant and antiradical activity. Vinpocetine has demonstrated similar, but somewhat less pronounced, activity. Ethylmethylhydroxypyridine succinate and actovegin have shown only the nonspecific superoxide dismutase activity which was by times lower than that of cytoflavin and vinpocetine.

Keywords:

consequences of ischemic stroke
oxidative stress
antioxidant activity
antiradical activity
cytoflavin
vinpocetine
actovegin and ethylmethylhydroxypyridine succinate

Authors:

Trofimova S.A.

Nauchno-issledovatel'skiĭ psikhonevrologicheskiĭ institut im. V.M. Bekhtereva, otdelenie reabilitatsii nevrologicheskikh bol'nykh, Sankt-Peterburg

Dubinina E.E.

Nauchno-issledovatel'skiĭ psikhonevrologicheskiĭ institut im. V.M. Bekhtereva, otdelenie reabilitatsii nevrologicheskikh bol'nykh, Sankt-Peterburg

Balunov O.A.

Nauchno-issledovatel'skiĭ psikhonevrologicheskiĭ institut im. V.M. Bekhtereva, otdelenie reabilitatsii nevrologicheskikh bol'nykh, Sankt-Peterburg

V Leonova N.

State Research Institute of Highly Pure Biopreparations of FMBA, St. Petersburg, Russia

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