Antibodies to native and denatured DNA in the serum of patients with schizophrenia depending on the clinical features of the disease

Smirnova L.P.

Mental Health Research Institute, Tomsk

Ermakov E.A.

Mental Health Research Institute, Tomsk;
Novosibirsk State University, Novosibirsk

Boyko A.S.

Mental Health Research Institute, Tomsk

Bokhan N.A.

Nauchno-issledovatel'skiĭ institut psikhicheskogo zdorov'ia Tomskogo nauchnogo tsentra Sibirskogo otdeleniia RAMN

Semke A.V.

Nauchno-issledovatel'skiĭ institut psikhicheskogo zdorov'ia Sibirskogo otdeleniia Rossiĭskoĭ akademii meditsinskikh nauk, Tomsk

Ivanova S.A.

Nauchno-issledovatel'skiĭ institut psikhicheskogo zdorov'ia Sibirskogo otdeleniia Rossiĭskoĭ akademii meditsinskikh nauk, Tomsk

Antibodies to native and denatured DNA in the serum of patients with schizophrenia depending on the clinical features of the disease

Authors:

Smirnova L.P., Ermakov E.A., Boyko A.S., Bokhan N.A., Semke A.V., Ivanova S.A.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(4): 47‑51

DOI: 10.17116/jnevro20161164147-51

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To cite this article:

Smirnova LP, Ermakov EA, Boyko AS, Bokhan NA, Semke AV, Ivanova SA. Antibodies to native and denatured DNA in the serum of patients with schizophrenia depending on the clinical features of the disease. S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(4):47‑51. (In Russ.)
https://doi.org/10.17116/jnevro20161164147-51

Подписка 2025-2 (S.S. Korsakov Journal of Neurology and Psychiatry)

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Objective. To study the correlations between the level of antibodies to native and denatured DNA and psychopathological symptoms and illness duration in patients with schizophrenia. Material and methods. The level of antibodies to native (double-stranded) DNA and denatured (single-stranded) DNA was studied in the serum of 50 patients with schizophrenia, including 12 patients with tardive dyskinesia (TD). The control group consisted of 30 people. Results. A significant twofold increase in antibodies to native DNA was detected in patients with TD. There was no correlation of the amount of antibodies to double-stranded DNA with the duration of disease and leading symptoms both between the groups of patients as well as in comparison with controls. A significant decrease in antibody levels to the denatured (single-stranded) DNA was found in schizophrenic patients compared to the control group (p=0.009). A significant decrease in the concentration of antibodies to single-stranded DNA in patients with increasing duration of the disease, as well as in patients with leading negative symptoms was revealed. Conclusion: The results suggest that anti-DNAantibodies may not play a major role in the pathogenesis of schizophrenia.

Keywords:

schizophrenia

anti-DNAantibodies

tardive dyskinesia

positive symptoms

negative symptoms

duration of disease

Authors:

Smirnova L.P.

Mental Health Research Institute, Tomsk

Ermakov E.A.

Mental Health Research Institute, Tomsk;
Novosibirsk State University, Novosibirsk

Boyko A.S.

Mental Health Research Institute, Tomsk

Bokhan N.A.

Nauchno-issledovatel'skiĭ institut psikhicheskogo zdorov'ia Tomskogo nauchnogo tsentra Sibirskogo otdeleniia RAMN

Semke A.V.

Nauchno-issledovatel'skiĭ institut psikhicheskogo zdorov'ia Sibirskogo otdeleniia Rossiĭskoĭ akademii meditsinskikh nauk, Tomsk

Ivanova S.A.

Nauchno-issledovatel'skiĭ institut psikhicheskogo zdorov'ia Sibirskogo otdeleniia Rossiĭskoĭ akademii meditsinskikh nauk, Tomsk

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