Neurotrophic peptides of сerebrolysin as a basis for anticonvulsant effect of the drug

Gromova O.A.; Kalacheva A.G.; Grishina T.R.; Bogacheva T.E.; Demidov V.I.; Torshin I.Yu.

doi:https://doi.org/10.17116/jnevro20161163155-62

Gromova O.A.

Ivanovo State Medical Academy, Ministry of Health of Russia

ORCID: 0000-0002-7663-710X

Kalacheva A.G.

Ivanovo State Medical Academy, Ministry of Health of Russia

Grishina T.R.

Ivanovo State Medical Academy, Ministry of Health of Russia, Ivanovo, Russia

Bogacheva T.E.

Ivanovo State Medical Academy, Ministry of Health of Russia, Ivanovo, Russia

Demidov V.I.

Ivanovskaia gosudarstvennaia meditsinskaia akademiia, Ivanovo

Torshin I.Yu.

Moscow Institute of Physics and Technology, Dolgoprudny

ORCID: 0000-0002-2659-7998

Neurotrophic peptides of сerebrolysin as a basis for anticonvulsant effect of the drug

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Gromova O.A., Kalacheva A.G., Grishina T.R., Bogacheva T.E., Demidov V.I., Torshin I.Yu.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(3): 55‑62

DOI: 10.17116/jnevro20161163155-62

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Gromova OA, Kalacheva AG, Grishina TR, Bogacheva TE, Demidov VI, Torshin IYu. Neurotrophic peptides of сerebrolysin as a basis for anticonvulsant effect of the drug. S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(3):55‑62. (In Russ.)
https://doi.org/10.17116/jnevro20161163155-62

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)

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Abstract:

Objective. To study an effect of cerebrolysin on the expression and severity of primary-generalized seizures caused by thiosemicarbazide and to analyze the corresponding molecular mechanisms.

Material and methods. The effects of cerebrolysin were studied on the thiosemicarbazide model of convulsions in 144 male rats. Cerebrolysin was introduced intraperitoneally in the dose of 2.5 ml/kg of body mass 5 days a week during 18 days.

Results and conclusion. Cerebrolysin reduces the severity and duration of seizures caused by thiosemicarbazide and increases the survival rate of animals. Cerebrolysin potentiates the anticonvulsant action of gabapentin and sodium valproate. Neurohistological analysis has shown that the thiosemicarbazide model results in the ischemic brain damage. Cerebrolysin substantially minimizes the ischemic injury of neurocytes induced by thiosemicarbazide and contributes to the restoration of brain tissue morphology.

Keywords:

seizures

ischemia

neuroprotection

neuropeptides

Cerebrolysin

gabapentin

sodium valproate

thiosemicarbazide

Authors:

Gromova O.A.

Ivanovo State Medical Academy, Ministry of Health of Russia

ORCID: 0000-0002-7663-710X

Kalacheva A.G.

Ivanovo State Medical Academy, Ministry of Health of Russia

Grishina T.R.

Ivanovo State Medical Academy, Ministry of Health of Russia, Ivanovo, Russia

Bogacheva T.E.

Ivanovo State Medical Academy, Ministry of Health of Russia, Ivanovo, Russia

Demidov V.I.

Ivanovskaia gosudarstvennaia meditsinskaia akademiia, Ivanovo

Torshin I.Yu.

Moscow Institute of Physics and Technology, Dolgoprudny

ORCID: 0000-0002-2659-7998

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