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Shchepankevich L.A.

Novosibirsk State Medical University;
Federal Research Center for Fundamental and Translational Medicine;
State Novosibirsk Regional Clinical Hospital

Nikolaev Yu.A.

Federal Research Centre for Fundamental and Translational Medicine

Dolgova N.A.

Research Institute of Experimental and Clinical Medicine

Chipova D.T.

H. Berbekov Kabardino-Balkarian State University

Optimization of hypolipidemic therapy in patients with ischemic stroke and diabetes mellitus

Authors:

Shchepankevich L.A., Nikolaev Yu.A., Dolgova N.A., Chipova D.T.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(2): 42‑45

DOI: 10.17116/jnevro20161162142-45

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Table of contents

OPTIMIZATION OF HYPOLIPIDEMIC THERAPY IN PATIENTS WITH ISCHEMIC STROKE AND DIABETES MELLITUS
OPTIMIZATION OF HYPOLIPIDEMIC THERAPY IN PATIENTS WITH ISCHEMIC STROKE AND DIABETES MELLITUS

To cite this article:

Shchepankevich LA, Nikolaev YuA, Dolgova NA, Chipova DT. Optimization of hypolipidemic therapy in patients with ischemic stroke and diabetes mellitus. S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(2):42‑45. (In Russ.)
https://doi.org/10.17116/jnevro20161162142-45

Подписка 2025-2 (S.S. Korsakov Journal of Neurology and Psychiatry)
 
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OBJECTIVE

S. Evaluation of effectiveness of Mexidol in optimization of hypolipidemic therapy in ischemic stroke and diabetes mellitus patients.

MATERIAL AND METHODS

Authors analyzed the indicators of lipid status: total cholesterol, low-density lipoproteins, high density lipoproteins, triglycerides and concentration of platelet factor-4, β-tromboglobulin, von Willebrand factor in 68 patients with acute ischemic stroke and diabetes mellitus. Authors investigate the dynamics of these parameters (1st, 21st, 3rd and 6th month after onset stroke) depending on timing and dose of Mexidol.

RESULTS

Long time therapy of Mexidol may optimize of hypolipidemic therapy in ischemic stroke and diabetes mellitus patients.

Keywords:

ischemic stroke
diabetes mellitus
comorbidity
lipids
hemostasis
mexidol

Authors:

Shchepankevich L.A.

Novosibirsk State Medical University;
Federal Research Center for Fundamental and Translational Medicine;
State Novosibirsk Regional Clinical Hospital

Nikolaev Yu.A.

Federal Research Centre for Fundamental and Translational Medicine

Dolgova N.A.

Research Institute of Experimental and Clinical Medicine

Chipova D.T.

H. Berbekov Kabardino-Balkarian State University

List of references:

  1. Goldstein L.B. Lipids in high-risk patients presenting with ischemic stroke or transient ischemic attack. Stroke. 2014;45(11):3180-3181. https://doi.org/10.1161/strokeaha.114.007436
  2. Tuttolomondo A. Relationship between diabetes and ischemic stroke: analysis of diabetes-related risk factors for stroke and of specific patterns of stroke associated with diabetes mellitus. J Diabetes Metab. 2015;06(05):544-551.  https://doi.org/10.4172/2155-6156.1000544
  3. Dedov I.I., Shestakova M.V., Vikulova O.K. National register of diabetes mellitus in Russian Federation. Diabetes mellitus. 2015;18(3):5-22. (In Russ.) https://doi.org/10.14341/DM201535-22
  4. Howangyin KY, Silvestre J-S. diabetes mellitus and ischemic diseases: molecular mechanisms of vascular repair dysfunction. Arteriosclerosis, Thrombosis, and Vascular Biology. 2014;34(6):1126-1135. https://doi.org/10.1161/atvbaha.114.303090
  5. Tanashyan M.M., Shchepankevich L.A., Orlov S.V., Telenkova N.G., Shabalina A.A., Kostyreva M.V. Hemorheology and hemostasis in stroke patients with type 2 diabetes and metabolic syndrome. Annals of Clinical and Experimental Neurology. 2014;3:14-20. 
  6. Volonghi I. Secondary prevention of ischaemic stroke. World Journal of Neurology. 2013;3(4):97.  https://doi.org/10.5316/wjn.v3.i4.97
  7. Shchepankevich LA, Vostrikova EV, Pilipenko PI. New form of a acetylsalicylic acid in the secondary prevention of ischemic stroke. Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova. 2013;113(4):92-94. 
  8. Voronina T.A. Domestic drug of new generation mexidol, main effects, mechanism of action, application. Moscow: Media Sphera Publishers; 2003.
  9. Ketete M, Cherqaoui R, Maqbool AR, Kwagyan J, Xu S, Randall OS. Endothelial dysfunction: The contribution of diabetes mellitus to the risk factor burden in a high risk population. JBiSE. 2013;06(06):593—597.  https://doi.org/10.4236/jbise.2013.66075
  10. Shchepankevich LA, Vostrikova EV, Pilipenko PI, Yarmoshchuk AV, Akhundova LE, Myasnikova NG, Fedorova KO, Kononova EA. Endothelial dysfunction in ischemic strokes in diabetes mellitus. Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova. 2011;111(12-2):28-30. 

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