The efficacy of pharmacological preconditioning in carotid endarterectomy

Kuznetsov M.R.

L.L. Levshina Institute of Cluster Oncology Russian Academy of Sciences — «First Moscow State Medical University named after I.I. Sechenov» of the Ministry of Health of Russia (Sechenov University);
N.V. Sklifosovsky Institute of Clinical Medicine Federal State Autonomous Educational Institution of Higher Education «Sechenov First Moscow State Medical university of the Ministry of Health of Russia» (Sechenov University)

ORCID: 0000-0001-6926-6809

Fedin A.I.

Pirogov Russian National Research Medical University

RSCI AuthorID: 167799
Scopus AuthorID: 7007163263
ORCID: 0000-0002-6996-2828

Karalkin A.V.

Pirogov City Hospital No. 1

Frolov K.B.

Pirogov Moscow City Hospital No. 1

Kunitsin N.V.

Pirogov City Hospital No. 1

Yumin S.M.

Pirogov Russian National Research Medical University

Kholopova E.A.

Pirogov Russian National Research Medical University

Knyazev A.V.

Pirogov Russian National Research Medical University

The efficacy of pharmacological preconditioning in carotid endarterectomy

Authors:

Kuznetsov M.R., Fedin A.I., Karalkin A.V., Frolov K.B., Kunitsin N.V., Yumin S.M., Kholopova E.A., Knyazev A.V.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(2): 34‑41

DOI: 10.17116/jnevro20161162134-41

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To cite this article:

Kuznetsov MR, Fedin AI, Karalkin AV, et al. . The efficacy of pharmacological preconditioning in carotid endarterectomy. S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(2):34‑41. (In Russ.)
https://doi.org/10.17116/jnevro20161162134-41

Подписка 2025 (S.S. Korsakov Journal of Neurology and Psychiatry)

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OBJECTIVE

To assess the efficacy of pharmacological preconditioning with actovegin in carotid endarterectomy.

MATERIAL AND METHODS

The study was based on the results of surgical treatment of 80 patients with hemodynamically significant uni- and bilateral lesions of carotid arteries. Half of the patients was operated immediately and others after pharmacological preconditioning with actovegin in dose of 1200 mg/daily during 1.5 months.

RESULTS

Pharmacological preconditioning with actovegin increased the cerebral perfusion determined with one-photon emission computed tomography that improved significantly results of the surgery. There were significant changes in patient’s state 7 days and 6 months after surgery. The improvement was correlated with the less number of asymptotic post-surgery ischemic strokes in different brain areas.

CONCLUSION

A positive role of pharmacological preconditioning with actovegin in surgical treatment of carotid artery stenosis has been demonstrated.

Keywords:

cerebrovascular insufficiency

carotid endarterectomy

preconditioning

cognitive function

cerebral blood flow autoregulation

reperfusion syndrome

actovegin

Authors:

Kuznetsov M.R.

ORCID: 0000-0001-6926-6809

Fedin A.I.

Pirogov Russian National Research Medical University

RSCI AuthorID: 167799
Scopus AuthorID: 7007163263
ORCID: 0000-0002-6996-2828

Karalkin A.V.

Pirogov City Hospital No. 1

Frolov K.B.

Pirogov Moscow City Hospital No. 1

Kunitsin N.V.

Pirogov City Hospital No. 1

Yumin S.M.

Pirogov Russian National Research Medical University

Kholopova E.A.

Pirogov Russian National Research Medical University

Knyazev A.V.

Pirogov Russian National Research Medical University

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