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Kuznetsova E.B.

GBOU VPO "Saratovskiĭ GMU im. V.I. Razumovskogo"

Neuron specific enolase as a measure of the efficacy of mexidol in patients with neurologic complications of primary hypothyroidism

Authors:

Kuznetsova E.B.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(12): 126‑129

DOI: 10.17116/jnevro2016116121126-129

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NEURON SPECIFIC ENOLASE AS A MEASURE OF THE EFFICACY OF MEXIDOL IN PATIENTS WITH NEUROLOGIC COMPLICATIONS OF PRIMARY HYPOTHYROIDISM
NEURON SPECIFIC ENOLASE AS A MEASURE OF THE EFFICACY OF MEXIDOL IN PATIENTS WITH NEUROLOGIC COMPLICATIONS OF PRIMARY HYPOTHYROIDISM

To cite this article:

Kuznetsova EB. Neuron specific enolase as a measure of the efficacy of mexidol in patients with neurologic complications of primary hypothyroidism. S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(12):126‑129. (In Russ.)
https://doi.org/10.17116/jnevro2016116121126-129

Подписка 2025-2 (S.S. Korsakov Journal of Neurology and Psychiatry)
 
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Objective. To evaluate the activity of neuron specific enolase (NSE) in patients with primary hypothyroidism (PGT) treated with mexidol. Material and methods. Patients with PGT (n=110) were examined before and after treatment. Neuropsychological and neurological status of the patients was studied. To assess the status of the peripheral nervous system, electroneuromyography was performed and serum NSE level was determined. Results and conclusion. The NSE activity depended on gender, age of the patient, duration of endocrinopathy and presence/absence of neurological symptoms. The clear positive dynamics of the majority of the parameters studied was noted during mexidol treatment. The efficacy of antioxidant therapy in these patients was confirmed.

Keywords:

neurological complications
primary hypothyroidism
neuron specific enolase
electroneuromyography
mexidol

Authors:

Kuznetsova E.B.

GBOU VPO "Saratovskiĭ GMU im. V.I. Razumovskogo"

List of references:

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  2. Piroeva KE, Tamkaeva MKh. Porazhenie nervnoi sistemy pri endokrinnykh zabolevaniyakh. M.: Meditsina; 2004. (In Russ.).
  3. Fadeev VV, Mel'nichenko GA. Gipotireoz (rukovodstvo dlya vrachei). M.: RKI Severo-press; 2002. (In Russ.).
  4. Weetman AP. Hypothyroidism: screening and subclinical disease. BMJ. 2007;314:1175-1178.
  5. Antonova OM. Neironspetsificheskaya enolaza i ee rol' v mekhanizmakh antitel'noi agressii v mozg: Dis. ... kand. med. nauk. M. 1997. (In Russ.).
  6. Zhukova IA, Alifirova VM, Zhukova NG. Neuron specific enolase as a nonspecific marker of the neurodegenerative process. Byulleten' sibirskoi meditsiny. 2011;2:15-21. (In Russ.).
  7. Tsybikov NN, Zueva AA, Zhigzhitova EB, Prutkina EV. Levels of neurospecific enolase and enolase-specific autoantibodies in blood serum of the patients with autoimmune thyropaties. Meditsinskaya immunologiya. 2010;12(1-2):147-150. (In Russ.). doi: 10.15789/1563-0625-2010-1-2-147-150
  8. Blennow K, Wallin A, Ekman R. Neuron specific enolase in cerebrospinal fluid: a biochemical marker for neuronal degeneration in dementia disorders. J Neurol Transm. 1994;8:3:183-191. doi: 10.1007/bf02260939
  9. Rabinowicz AL, Correale J, Boutros RB, Couldwell WT, Henderson CW, DeGiorgio CM. Neuron specific enolase is increased after single seizures during inpatient video/EEG monitoring. Epilepsia. 1996;37:122-125. doi: 10.1111/j.1528-1157.1996.tb00002.x

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