A study of the association between the kynurenine-3-monooxygenase gene and depression

Lezheĭko T.V.; Golimbet V.E.; Andryushchenko A.V.; Melik-pashaian A.E.; Mironova E.V.

doi:https://doi.org/10.17116/jnevro201611612192-95

Lezheĭko T.V.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Golimbet V.E.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Andryushchenko A.V.

Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology, Moscow, Russia, 119071

Melik-pashaian A.E.

Heratsi Yerevan State Medical University, Yerevan, Armenia

Mironova E.V.

Heratsi Yerevan State Medical University, Yerevan, Armenia

A study of the association between the kynurenine-3-monooxygenase gene and depression

Authors:

Lezheĭko T.V., Golimbet V.E., Andryushchenko A.V., Melik-pashaian A.E., Mironova E.V.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(12): 92‑95

DOI: 10.17116/jnevro201611612192-95

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To cite this article:

Lezheĭko TV, Golimbet VE, Andryushchenko AV, Melik-pashaian AE, Mironova EV. A study of the association between the kynurenine-3-monooxygenase gene and depression. S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(12):92‑95. (In Russ.)
https://doi.org/10.17116/jnevro201611612192-95

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)

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Abstract:

Objective. To study the association between the kynurenine 3-monooxygenase (KMO) and depression. Material and methods. КМО rs2275163 (C/T) and rs1053230 (A /G) polymorphisms were genotyped in patients diagnosed with depression (the main group) and age — and sex-matched healthy people. Results. The rs2275163 polymorphism was not associated with depression. There was the association between the rs1053230 polymorphism and depression. The frequency of the low expression genotype GG was higher in the main group compared to controls (р=0.001, ОШ 2.8 (95% ДИ 1.73—4.24). This genotype was earlier reported to be associated with the increased levels of kynurenic acid in patients with bipolar disorders. Conclusion. The genotype GG can be considered as a risk factor of depression.

Keywords:

depression

inflammation

tryptophan

kynurenine

gen

depression

kynurenine 3-monooxygenase

inflammation

tryptophan

kynurenine

gen

kynurenine 3-monooxygenase

Authors:

Lezheĭko T.V.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Golimbet V.E.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Andryushchenko A.V.

Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology, Moscow, Russia, 119071

Melik-pashaian A.E.

Heratsi Yerevan State Medical University, Yerevan, Armenia

Mironova E.V.

Heratsi Yerevan State Medical University, Yerevan, Armenia

Close metadata

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