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Pronin A.V.

Ivanovo State Medical Academy, Ivanovo

Gromova O.A.

Rossiĭskiĭ satellitnyĭ tsentr instituta mikroélementov IuNESKO;
Laboratoriia vychislitel'noĭ i sistemnoĭ biologii VTs RAN im. A.A. Dorodnitsyna;
kafedra farmakologii i klinicheskoĭ farmakologii Ivanovskoĭ gosudarstvennoĭ meditsinskoĭ akademii

Sardaryan I.S.

Moscow Institute of Physics and Technology

Torshin I.Iu.

Rossiĭskiĭ satellitnyĭ tsentr instituta mikroélementov IuNESKO;
Laboratoriia vychislitel'noĭ i sistemnoĭ biologii VTs RAN im. A.A. Dorodnitsyna

Stel'mashuk E.V.

NTs nevrologii RAMN

Ostrenko K.S.

St. Petersburg State Pediatric Medical University, St. Petersburg, Russia

Alexandrova O.P.

Neurology Research Center, Russian Academy of Sciences, Moscow

Genrikhs E.E.

Neurology Research Center, Russian Academy of Sciences, Moscow

Khaspekov L.G.

All-Russian Research Institute of Physiology, Biochemistry and Food of Animals, Kaluga Region, Borovsk, Russia

Adaptogenic and neuroprotective effects of lithium ascorbate

Authors:

Pronin A.V., Gromova O.A., Sardaryan I.S., Torshin I.Iu., Stel'mashuk E.V., Ostrenko K.S., Alexandrova O.P., Genrikhs E.E., Khaspekov L.G.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(12): 86‑91

DOI: 10.17116/jnevro201611612186-91

Read: 9991 times

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Table of contents

ADAPTOGENIC AND NEUROPROTECTIVE EFFECTS OF LITHIUM ASCORBATE
ADAPTOGENIC AND NEUROPROTECTIVE EFFECTS OF LITHIUM ASCORBATE

To cite this article:

Pronin AV, Gromova OA, Sardaryan IS, et al. . Adaptogenic and neuroprotective effects of lithium ascorbate. S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(12):86‑91. (In Russ.)
https://doi.org/10.17116/jnevro201611612186-91

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
 
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Abstract:

Objective.Investigation of the neuroprotective properties of lithium ascorbate on the stress models in vivo and in vitro. Materials and methods. Neurocytological and behavioral studies on nerve cell culture and animal stress models. Results. Significant neuroprotective effect of lithium ascorbate in neuronal cultures exposed to glutamate toxicity and adaptogenic effect of this drug in stress model in rats were shown. Conclusion. The results suggest lithium ascorbate has a high neuroprotective potential in stress models in vivo and in vitro.

Keywords:

stress
neurocytology
glutamate
lithium ascorbate

Authors:

Pronin A.V.

Ivanovo State Medical Academy, Ivanovo

Gromova O.A.

Rossiĭskiĭ satellitnyĭ tsentr instituta mikroélementov IuNESKO;
Laboratoriia vychislitel'noĭ i sistemnoĭ biologii VTs RAN im. A.A. Dorodnitsyna;
kafedra farmakologii i klinicheskoĭ farmakologii Ivanovskoĭ gosudarstvennoĭ meditsinskoĭ akademii

Sardaryan I.S.

Moscow Institute of Physics and Technology

Torshin I.Iu.

Rossiĭskiĭ satellitnyĭ tsentr instituta mikroélementov IuNESKO;
Laboratoriia vychislitel'noĭ i sistemnoĭ biologii VTs RAN im. A.A. Dorodnitsyna

Stel'mashuk E.V.

NTs nevrologii RAMN

Ostrenko K.S.

St. Petersburg State Pediatric Medical University, St. Petersburg, Russia

Alexandrova O.P.

Neurology Research Center, Russian Academy of Sciences, Moscow

Genrikhs E.E.

Neurology Research Center, Russian Academy of Sciences, Moscow

Khaspekov L.G.

All-Russian Research Institute of Physiology, Biochemistry and Food of Animals, Kaluga Region, Borovsk, Russia

Close metadata

References:

  1. Sel'e G. Stress bez distressa, Moskva, Progress, 1979, 123 с. (In Russ.).
  2. Hemanth Kumar BS, Mishra SK, Rana P, Singh S, Khushu S. Neurodegenerative evidences during early onset of depression in CMS rats as detected by proton magnetic resonance spectroscopy at 7 T. Behav Brain Res. 2012;232(1):53-9. doi: 10.1016/j.bbr.2012.03.011
  3. Cuadrado-Tejedor M, Ricobaraza A, Del Río J, Frechilla D, Franco R, Pérez-Mediavilla A, Garcia-Osta A. Chronic mild stress in mice promotes cognitive impairment and CDK5-dependent tau hyperphosphorylation. Behav Brain Res. 2011; 220(2):338-43. doi: 10.1016/j.bbr.2011.01.005
  4. Qiao H, An SC, Ren W, Ma XM. Progressive alterations of hippocampal CA3-CA1 synapses in an animal model of depression. Behav Brain Res. 2014; 275:191-200. doi: 10.1016/j.bbr.2014.08.040
  5. AbdAlla S, El-Hakim A, Abdelbaset A, Elfaramawy Y, Quitterer U. Inhibition of ACE Retards Tau Hyperphosphorylation and Signs of Neuronal Degeneration in Aged Rats Subjected to Chronic Mild Stress. Biomed Res Int. 2015;2015:917156. doi: 10.1155/2015/917156. doi.org/10.1155/2015/917156
  6. Hynd MR, Scott HL, Dodd PR. Glutamate-mediated excitotoxicity and neurodegeneration in Alzheimer's disease. Neurochem Int. 2004 Oct;45(5):583-95. doi.org/10.1016/j.neuint.2004.03.007
  7. Allagui MS, Nciri R, Rouhaud MF, Murat JC, El Feki A, Croute F, Vincent C. Long-term exposure to low lithium concentrations stimulates proliferation, modifies stress protein expression pattern and enhances resistance to oxidative stress in SH-SY5Y cells. Neurochem Res. 2009;34(3):453-62 Epub 2008 Au. doi.org/10.1007/s11064-008-9804-8
  8. Sharifzadeh M, Aghsami M, Gholizadeh S, Tabrizian K, Soodi M, Khalaj S, Ranjbar A, Hosseini-Sharifabad A, Roghani A, Karimfar MH. Protective effects of chronic lithium treatment against spatial memory retention deficits induced by the protein kinase AII inhibitor H-89 in rats. Pharmacology. 2007;80(2-3):158-65. doi.org/10.1159/000103265
  9. Moore GJ, Bebchuk JM, Wilds IB, Chen G, Manji HK. Lithium-induced increase in human brain grey matter. Lancet. 2000;356(9237):1241-1242. doi.org/10.1016/s0140-6736(00)02793-8
  10. Lyoo IK, Dager SR, Kim JE, Yoon SJ, Friedman SD, Dunner DL, Renshaw PF. Lithium-induced gray matter volume increase as a neural correlate of treatment response in bipolar disorder: a longitudinal brain imaging study. Neuropsychopharmacol 2010;35(8):1743-50. doi.org/10.1038/npp.2010.41
  11. Sassi RB, Nicoletti M, Brambilla P, Mallinger AG, Frank E, Kupfer DJ, Keshavan MS, Soares JC. Increased gray matter volume in lithium-treated bipolar disorder patients. Neurosci Lett. 2002;329(2):243-245. doi.org/10.1016/s0304-3940(02)00615-8
  12. Andreeva N.A., Stel'mashuk E.V., Isaev N.K., Ostrovskaya R.U., Gudasheva T.A., Viktorov I.V. Neiroprotektornye effekty nootropnogo dipeptida GVS-111 pri kislorodno-glyukoznoi deprivatsii, glutamatnoi toksichnosti i oksidativnom stresse in vitro. // Byull. eksperim. biol. med. 2000. т. 130. № 10. с. 418-421. (In Russ.).
  13. Stel'mashuk E.V., Novikova S.V., Isaev N.K. Vliyanie glutamina na gibel' kul'tivirovannykh zernistykh neironov, indutsirovannuyu glyukoznoi deprivatsiei i khimicheskoi gipoksiei. Biokhimiya. - 2010. - т. 75. в. 8. с. 1150-1156. (In Russ.).
  14. Gromova O.A., Torshin I.Iu., Gogoleva I.V., Pronin A.V., Stel'mashuk E.V., Isaev N.K., Genrikhs E.E., Demidov V.I., Volkov A.Iu., Khaspekov G.L., Aleksandrova O.P. Pharmacokinetic and pharmacodynamic synergism between neuropeptides and lithium in the neurotrophic and neuroprotective action of cerebrolysin. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. 2015; 3: 65-72. doi: 10.17116/jnevro201511531 (In Russ).
  15. Senatorov V.V., Ren M., Kanai H., Wei H., Chuang D.-M. Short-term lithium treatment promotes neuronal survival and proliferation in rat striatum infused with quinolinic acid, an excitotoxic model of Huntington’s disease. Mol. Psychiatry, 2004, 9, 371–385. doi.org/10.1038/sj.mp.4001463
  16. Dwivedi T., Zhang H., Lithium-induced neuroprotection is associated with epigenetic modification of specific BDNF gene promoter and altered expression of apoptotic-regulatory proteins. Front. Neurosci., 2015, 8, Art. 457. doi.org/10.3389/fnins.2014.00457
  17. De-Paula V., Kerr D.S., De Carvalho M.P.F., Schaeffer E.L., Talib L.L., Gattaz W.F., Forlenza O.V. Long-term lithium treatment increases cPLA2 and iPLA2 activity in cultured cortical and hippocampal neurons. Molecules, 2015, 20, 19878–19885. doi.org/10.3390/molecules201119663
  18. Emamghoreishi M., Keshavarz M., Nekooeian A.A. Acute and chronic effects of lithium on BDNF and GDNF mRNA and protein levels in rat primary neuronal, astroglial and neuroastroglia cultures. Iran. J. Basic Med. Sci., 2015, 18, 240-246.
  19. Hashimoto R., Hough C., Nakazawa T., Yamamoto T., Chuang D.-M. Lithium protection against glutamate excitotoxicity in rat cerebral cortical neurons: involvement of NMDA receptor inhibition possibly by decreasing NR2B tyrosine phosphorylation. J. Neurochem., 2002, 80, 589-597. doi.org/10.1046/j.0022-3042.2001.00728.x
  20. Nonaka S., Hough C., Chuang D.-M. Chronic lithium treatment robustly protects neurons in the central nervous system against excitotoxicity by inhibiting N-methyl-D-aspartate receptor-mediated calcium influx. PNAS, 1998, 95, 2642-2647. doi.org/10.1073/pnas.95.5.2642
  21. Leeds R.R., Yu F., Wang Z., Chiu C.-T., Zhang Y., Leng Y., Linares G.R., Chuang D.-M.. A new avenue for lithium: intervention in traumatic brain injury. ACS Chem. Neurosci., 2014, 5, 422−433. doi.org/10.1021/cn500040g
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