Alterations of serum neurospecific proteins concentrations in patients with metabolic syndrome

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Kadyrova I.A.

Karagandinskiĭ gosudarstvennyĭ meditsinskiĭ universitet, Karaganda, Kazakhstan

Kadyrov A.S.

Karaganda State Medical University, Karaganda, Kazakhstan

Alterations of serum neurospecific proteins concentrations in patients with metabolic syndrome

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Kadyrova I.A., Kadyrov A.S.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(11): 92‑97

DOI: 10.17116/jnevro201611611192-97

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To cite this article:

Kadyrova IA, Kadyrov AS. Alterations of serum neurospecific proteins concentrations in patients with metabolic syndrome. S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(11):92‑97. (In Russ.)
https://doi.org/10.17116/jnevro201611611192-97

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)

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Abstract:

Objective. Metabolic syndrome (MS) — is a complex of metabolic, hormonal and clinical disorders which are risk factors for cardiovascular disease. The study aimed to determine the markers NSE, GFAP, MMP-9 in patients with MS and to assess their prognostic value in the development of acute stroke. Material and methods. A cross-sectional analytical studyincluded 157 patients stratified into 4groups (control group, patients with MS, patients with ischemic stroke and patients with ischemic stroke and MS). Laboratory examinations included measurements of MS parameters(total cholesterol, blood glucose, cholesterol, HDL and LDL, triglycerides) and concentrations of neurospecific markers NSE, GFAP and MMP-9 by ELISA. Results and conclusion. A relationship between MS and increased concentration of NSE is found. This indicates the presence of neuronal brain injury in patients with metabolic syndrome. There were no changesin the concentrations of GFAP and MMP-9 in patients with MS.

Keywords:

stroke

NSE

GFAP

MMP-9

metabolic syndrome

Authors:

Kadyrova I.A.

Karagandinskiĭ gosudarstvennyĭ meditsinskiĭ universitet, Karaganda, Kazakhstan

Kadyrov A.S.

Karaganda State Medical University, Karaganda, Kazakhstan

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References:

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